Title:
NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2003091264
Kind Code:
A3
Abstract:
Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.
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Inventors:
CHEN JAMES M (US)
CHEN XIAOWU (US)
KIM CHOUNG U (US)
LEE WILLIAM A (US)
LEE CHRISTOPHER P (US)
TARIO JAMES D (US)
XU LIANHONG (US)
NELSON PETER H (US)
CHEN XIAOWU (US)
KIM CHOUNG U (US)
LEE WILLIAM A (US)
LEE CHRISTOPHER P (US)
TARIO JAMES D (US)
XU LIANHONG (US)
NELSON PETER H (US)
Application Number:
PCT/US2003/012926
Publication Date:
March 11, 2004
Filing Date:
April 25, 2003
Export Citation:
Assignee:
GILEAD SCIENCES INC (US)
CHEN JAMES M (US)
CHEN XIAOWU (US)
KIM CHOUNG U (US)
LEE WILLIAM A (US)
LEE CHRISTOPHER P (US)
TARIO JAMES D (US)
XU LIANHONG (US)
NELSON PETER H (US)
CHEN JAMES M (US)
CHEN XIAOWU (US)
KIM CHOUNG U (US)
LEE WILLIAM A (US)
LEE CHRISTOPHER P (US)
TARIO JAMES D (US)
XU LIANHONG (US)
NELSON PETER H (US)
International Classes:
C12N9/99; A61K31/4155; A61K31/66; A61K31/665; A61K31/675; A61P31/18; A61P43/00; C07D213/75; C07D213/85; C07D231/12; C07D231/20; C07D233/42; C07D239/48; C07D239/80; C07D243/04; C07D265/18; C07D307/68; C07D401/06; C07D403/06; C07D471/14; C07D491/04; C07F9/02; C07F9/38; C07F9/40; C07F9/44; C07F9/58; C07F9/62; C07F9/645; C07F9/6506; C07F9/6509; C07F9/6512; C07F9/653; C07F9/6533; C07F9/655; C07F9/6558; C07F9/6561; C07F9/6584; C12N9/16; C12Q1/18; C12Q1/37; C12Q1/44; C12Q1/70; G01N33/04; G01N33/50; C07F; (IPC1-7): C07F9/38; C07F9/40; A61K31/4155
Domestic Patent References:
| WO2001096329A1 | 2001-12-20 | |||
| WO2002003997A1 | 2002-01-17 | |||
| WO2001017982A1 | 2001-03-15 |
Foreign References:
| US6312662B1 | 2001-11-06 | |||
| US5413996A | 1995-05-09 | |||
| EP0786455A1 | 1997-07-30 |
Other References:
MENENDEZ-ARIAS L: "Targeting HIV: antiretroviral therapy and development of drug resistance", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 8, 1 August 2002 (2002-08-01), pages 381 - 388, XP004386181, ISSN: 0165-6147
VIELHABER, BERND: "Bericht vom 3rd International Workshop on Salvage Therapy for HIV-Infection, 12-14. April 2000, Chicago, Teil I", DEUTSCHE AIDS-HILFE E.V. FAXREPORT ZU HIV UND AIDS, no. 9 and 10, - 29 May 2000 (2000-05-29), Berlin, pages 1 - 12, XP002247382
CLERCQ DE E: "NEW DEVELOPMENTS IN ANTI-HIV CHEMOTHERAPY", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 8, no. 13, November 2001 (2001-11-01), pages 1543 - 1572, XP009012547, ISSN: 0929-8673
VIELHABER, BERND: "Bericht vom 3rd International Workshop on Salvage Therapy for HIV-Infection, 12-14. April 2000, Chicago, Teil I", DEUTSCHE AIDS-HILFE E.V. FAXREPORT ZU HIV UND AIDS, no. 9 and 10, - 29 May 2000 (2000-05-29), Berlin, pages 1 - 12, XP002247382
CLERCQ DE E: "NEW DEVELOPMENTS IN ANTI-HIV CHEMOTHERAPY", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 8, no. 13, November 2001 (2001-11-01), pages 1543 - 1572, XP009012547, ISSN: 0929-8673
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