Title:
NON-PEPTIDE CCR1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PROGRESSIVE RENAL FIBROSIS
Document Type and Number:
WIPO Patent Application WO2003013656
Kind Code:
A3
Abstract:
This invention is directed to pharmaceutical compositions useful in treating progressive renal fibrosis in mammals comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of a non-peptide CCR1 receptor antagonist.
Inventors:
HORUK RICHARD (US)
Application Number:
PCT/US2002/024763
Publication Date:
May 01, 2003
Filing Date:
August 05, 2002
Export Citation:
Assignee:
SCHERING AG (DE)
HORUK RICHARD (US)
HORUK RICHARD (US)
International Classes:
A61K45/00; A61K31/495; A61P13/12; (IPC1-7): A61P13/12; A61K31/495
Foreign References:
| US6207665B1 | 2001-03-27 |
Other References:
VIELHAUER VOLKER ET AL: "Obstructive nephropathy in the mouse: Progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes.", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 12, no. 6, June 2001 (2001-06-01), pages 1173 - 1187, XP008014499, ISSN: 1046-6673
LIANG MEINA ET AL: "Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 25, 23 June 2000 (2000-06-23), pages 19000 - 19008, XP002233484, ISSN: 0021-9258
ANDERS H-J ET AL: "A CHEMOKINE RECEPTOR CCR-1 ANTAGONIST REDUCES RENAL FIBROSIS AFTER UNILATERAL URETER LIGATION", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 109, no. 2, January 2002 (2002-01-01), pages 251 - 259, XP001148403, ISSN: 0021-9738
LIANG MEINA ET AL: "Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 25, 23 June 2000 (2000-06-23), pages 19000 - 19008, XP002233484, ISSN: 0021-9258
ANDERS H-J ET AL: "A CHEMOKINE RECEPTOR CCR-1 ANTAGONIST REDUCES RENAL FIBROSIS AFTER UNILATERAL URETER LIGATION", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 109, no. 2, January 2002 (2002-01-01), pages 251 - 259, XP001148403, ISSN: 0021-9738
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