Title:
NON-STEROIDAL ANALOGS OF 2-METHOXYESTRADIOL
Document Type and Number:
WIPO Patent Application WO2003063791
Kind Code:
A3
Abstract:
Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis and proliferative activity by administering non-steroidal derivatives of 2-methoxyestradiol of the general formula:(I) wherein the variables are defined in the specification.
Inventors:
AGOSTON GREGORY (US)
SHAH JAMSHED H (US)
HUNSUCKER KIMBERLY A (US)
TRESTON ANTHONY M (US)
PRIBLUDA VICTOR S (US)
SHAH JAMSHED H (US)
HUNSUCKER KIMBERLY A (US)
TRESTON ANTHONY M (US)
PRIBLUDA VICTOR S (US)
Application Number:
PCT/US2003/002917
Publication Date:
December 31, 2003
Filing Date:
January 30, 2003
Export Citation:
Assignee:
ENTREMED INC (US)
AGOSTON GREGORY (US)
SHAH JAMSHED H (US)
HUNSUCKER KIMBERLY A (US)
TRESTON ANTHONY M (US)
PRIBLUDA VICTOR S (US)
AGOSTON GREGORY (US)
SHAH JAMSHED H (US)
HUNSUCKER KIMBERLY A (US)
TRESTON ANTHONY M (US)
PRIBLUDA VICTOR S (US)
International Classes:
C07C43/23; (IPC1-7): C07C43/21; A61K31/01; A61K31/03; A61K31/075; A61K31/085; C07C15/24; C07C25/22; C07C43/215; C07C43/225; C07C43/23
Domestic Patent References:
| WO1999022728A1 | 1999-05-14 |
Foreign References:
| US5629340A | 1997-05-13 | |||
| US6514971B1 | 2003-02-04 |
Other References:
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January 1993, VAN NOSTRAND REINHOLD COMPANY, NEW YORK, article LEWIS R.J.: "Hawley's condensed chemical dictionary", pages: 577, XP002969129
January 1993, VAN NOSTRAND REINHOLD COMPANY, NEW YORK, article LEWIS R.J.: "Hawley's condensed chemical dictionary", pages: 128 - 129, XP002969130
GASLINI ET AL.: "Reaction of eugenol with synthesis gas. Synthesis of 5,6,7,8-tetrahydro-3-methoxy-2-naphthol", JOURNAL OF ORGANIC CHEMISTRY, vol. 29, no. 5, May 1964 (1964-05-01), pages 1177 - 1180
DATABASE USPATFULL [online] IMAMURA ET AL.: "Method for manufacture of dihydric phenols", XP002969131, accession no. STN Database accession no. 76:20259
PAKALA ET AL.: "Modulation of endothelial cell proliferation by retinoid x receptor agonists", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 385, no. 2/3, September 1999 (1999-09-01), pages 255 - 261, XP002969132
DATABASE CAPLUS [online] SHIM ET AL.: "Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation", XP002969133, accession no. STN Database accession no. 2002:418369
January 1993, VAN NOSTRAND REINHOLD COMPANY, NEW YORK, article LEWIS R.J.: "Hawley's condensed chemical dictionary", pages: 577, XP002969129
January 1993, VAN NOSTRAND REINHOLD COMPANY, NEW YORK, article LEWIS R.J.: "Hawley's condensed chemical dictionary", pages: 128 - 129, XP002969130
GASLINI ET AL.: "Reaction of eugenol with synthesis gas. Synthesis of 5,6,7,8-tetrahydro-3-methoxy-2-naphthol", JOURNAL OF ORGANIC CHEMISTRY, vol. 29, no. 5, May 1964 (1964-05-01), pages 1177 - 1180
DATABASE USPATFULL [online] IMAMURA ET AL.: "Method for manufacture of dihydric phenols", XP002969131, accession no. STN Database accession no. 76:20259
PAKALA ET AL.: "Modulation of endothelial cell proliferation by retinoid x receptor agonists", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 385, no. 2/3, September 1999 (1999-09-01), pages 255 - 261, XP002969132
DATABASE CAPLUS [online] SHIM ET AL.: "Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation", XP002969133, accession no. STN Database accession no. 2002:418369
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