Title:
NON-STEROIDAL INFALMMATION INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004071389
Kind Code:
A3
Abstract:
A compound of formula (I) wherein: n represents an integer 0, 1 or 2; X represents, O, S, NR<6a>, or CHR<6b>; R<1> represents hydrogen, halogen such as F, Cl or Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR<8>R<9> such as NH2, NR<8>COR<9> such as -NHCHO or -NHCOCH3, COOR<7> or CONR<8>R<9>; R<2> represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR<8>R<9> such as NH2, NR<8>COR<9> such as -NHCHO or -NHCOCH3, COOR<7> or CONR<8>R<9>; R<3> represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR<8>R<9> such as NH2, NR<8>COR<9> such as -NHCHO or -NHCOCH3, COOR<7>, CONR<8>R<9>; R<4> represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR<8>R<9> such as NH2, NR<8>COR<9> such as -NHCHO or -NHCOCH3, COOR<7> or CONR<8>R<9>; R<5> represents H, C1-6 alkyl, or C1-6 alkenyl; R<6a> represents hydrogen, C1-6 alkyl, CO2C1-3 alkyl, COC1-3 alkyl or SO2C1-3 alkyl; R<6b> represents hydrogen, or C1-6 alkyl; R<7> represents hydrogen, C1-6 alkyl, C1-3 alkyleneSiC1-3 alkyl such as -CH2CH2Si(CH3)3; R<8> and R<9> independently represent hydrogen or C1-6 alkyl; including pharmaceutically acceptable esters, amides and carbamates thereof, salts thereof, solvates thereof, and solvates of such pharmaceutically acceptable esters, amides, carbamates and salts.
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Inventors:
BARKER MICHAEL DAVID (GB)
DEMAINE DEREK ANTHONY (GB)
HOUSE DAVID (GB)
INGLIS GRAHAM GEORGE ADAM (GB)
JOHNSTON MICHAEL JOHN (GB)
JONES HAYDN TERENCE (GB)
MACDONALD SIMON JOHN FAWCETT (GB)
MCLAY IAIN MCFARLANE (GB)
SHANAHAN STEPHEN (GB)
SKONE PHILIP ALAN (GB)
VINADER MARIA VICTORIA (GB)
DEMAINE DEREK ANTHONY (GB)
HOUSE DAVID (GB)
INGLIS GRAHAM GEORGE ADAM (GB)
JOHNSTON MICHAEL JOHN (GB)
JONES HAYDN TERENCE (GB)
MACDONALD SIMON JOHN FAWCETT (GB)
MCLAY IAIN MCFARLANE (GB)
SHANAHAN STEPHEN (GB)
SKONE PHILIP ALAN (GB)
VINADER MARIA VICTORIA (GB)
Application Number:
PCT/EP2004/001507
Publication Date:
December 02, 2004
Filing Date:
February 13, 2004
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
BARKER MICHAEL DAVID (GB)
DEMAINE DEREK ANTHONY (GB)
HOUSE DAVID (GB)
INGLIS GRAHAM GEORGE ADAM (GB)
JOHNSTON MICHAEL JOHN (GB)
JONES HAYDN TERENCE (GB)
MACDONALD SIMON JOHN FAWCETT (GB)
MCLAY IAIN MCFARLANE (GB)
SHANAHAN STEPHEN (GB)
SKONE PHILIP ALAN (GB)
VINADER MARIA VICTORIA (GB)
BARKER MICHAEL DAVID (GB)
DEMAINE DEREK ANTHONY (GB)
HOUSE DAVID (GB)
INGLIS GRAHAM GEORGE ADAM (GB)
JOHNSTON MICHAEL JOHN (GB)
JONES HAYDN TERENCE (GB)
MACDONALD SIMON JOHN FAWCETT (GB)
MCLAY IAIN MCFARLANE (GB)
SHANAHAN STEPHEN (GB)
SKONE PHILIP ALAN (GB)
VINADER MARIA VICTORIA (GB)
International Classes:
A61P29/00; C07D265/02; C07D413/12; (IPC1-7): C07D265/02; A61K31/536; A61P29/00; C07D413/12
Domestic Patent References:
| WO2002010143A1 | 2002-02-07 | |||
| WO2000032584A2 | 2000-06-08 |
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