NONINVASIVE DETECTION OF FETAL ANEUPLOIDY IN EGG DONOR PREGNANCIES

Title:

NONINVASIVE DETECTION OF FETAL ANEUPLOIDY IN EGG DONOR PREGNANCIES

Document Type and Number:

WIPO Patent Application WO/2014/099919

Kind Code:

A3

Abstract:

The present invention provides assay systems and methods for determining the percent fetal contribution of cell-free DNA in a maternal sample from a pregnant female with an egg donor pregnancy. Further provided, are assay systems and methods for determining a statistical likelihood of the presence or absence of a fetal aneuploidy in a maternal sample using a determined percent fetal cell-free DNA in the sample.

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Inventors:

OLIPHANT ARNOLD (US)
WANG ERIC (US)
STRUBLE CRAIG (US)

Application Number:

PCT/US2013/075683

Publication Date:

October 09, 2014

Filing Date:

December 17, 2013

Export Citation:

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Assignee:

ARIOSA DIAGNOSTICS INC (US)

International Classes:

C12Q1/68; C40B20/00; G16B20/00; G16B20/10; G16B20/20; G16B30/00

Domestic Patent References:

WO2010033578A2

2010-03-25

Foreign References:

US20110124515A1	2011-05-26
US20120122701A1	2012-05-17
US20120053062A1	2012-03-01
US20120034603A1	2012-02-09

Other References:

SPARKS ET AL.: "Noninvasive prenatal detection and selective analysis of cell -free DNA obtained from maternal blood: evaluation for trisomy 21 and trisomy 18", AM J OBSTET GYNECOL, vol. 206, no. 4, April 2012 (2012-04-01), pages 319.E1 - 319.E9, XP055024123
ASHOOR ET AL.: "Fetal fraction in maternal plasma cell -free DNA at 11-13 weeks' gestation: effect of maternal and fetal factors.", FETAL DIAGN THER, vol. 31, no. 4, 4 May 2012 (2012-05-04), pages 237 - 243, XP055257876

Attorney, Agent or Firm:

BRASHEARS, Sarah (475 N. Whisman Road Suite 40, Mountain View CA, US)

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