Title:
NOTCH RECEPTOR AGONISTS AND USES
Document Type and Number:
WIPO Patent Application WO2002024221
Kind Code:
A3
Abstract:
The present invention is directed to methods of alleviating prostate disorders by activation of the Notch1 receptor. Also provided herein are methods for detecting and diagnosing prostate disorders, wherein the specific disorder is prostate cancer.
Inventors:
GAO WEI-QIANG
KOEPPEN HARTMUT
ROSS SARAJANE
SHOU JIANYONG
KOEPPEN HARTMUT
ROSS SARAJANE
SHOU JIANYONG
Application Number:
PCT/US2001/029152
Publication Date:
August 22, 2002
Filing Date:
September 17, 2001
Export Citation:
Assignee:
GENENTECH INC (US)
International Classes:
G01N33/50; A61K38/00; A61K38/17; A61K39/395; A61K45/00; A61P13/08; A61P15/00; A61P35/00; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/574; (IPC1-7): A61K38/17; A61K39/395; A61P13/08; A61P35/00; C12Q1/68; G01N33/50; G01N33/574
Domestic Patent References:
| WO1999004746A2 | 1999-02-04 | |||
| WO1998020142A1 | 1998-05-14 |
Other References:
C. LINDSELL ET AL.: "Jagged: A mammalian ligand that activates Notch1.", CELL, vol. 80, no. 6, 24 March 1995 (1995-03-24), Cambridge, MA, USA, pages 909 - 917, XP002090589
B. LUO ET AL.: "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 10, October 1997 (1997-10-01), Washington, DC, USA, pages 6057 - 6067, XP000938415
A. ZLOBIN ET AL.: "Toward a rational design of cell fate modifiers: Notch signaling as a target for novel biopharmaceuticals.", CURRENT PHARMACEUTICAL BIOTECHNOLOGY, vol. 11, no. 1, July 2000 (2000-07-01), pages 83 - 106, XP008004456
J. SHOU ET AL.: "Dynamics of Notch expression during murine prostate development and tumorigenesis.", CANCER RESEARCH, vol. 61, no. 19, 1 October 2001 (2001-10-01), Philadelphia, PA, USA, pages 7291 - 7297, XP002202219
B. LUO ET AL.: "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 10, October 1997 (1997-10-01), Washington, DC, USA, pages 6057 - 6067, XP000938415
A. ZLOBIN ET AL.: "Toward a rational design of cell fate modifiers: Notch signaling as a target for novel biopharmaceuticals.", CURRENT PHARMACEUTICAL BIOTECHNOLOGY, vol. 11, no. 1, July 2000 (2000-07-01), pages 83 - 106, XP008004456
J. SHOU ET AL.: "Dynamics of Notch expression during murine prostate development and tumorigenesis.", CANCER RESEARCH, vol. 61, no. 19, 1 October 2001 (2001-10-01), Philadelphia, PA, USA, pages 7291 - 7297, XP002202219
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