Title:
NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLCHALCOGENO LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS
Document Type and Number:
WIPO Patent Application WO/2008/059865
Kind Code:
A1
Abstract:
Disclosed is a novel 1,2-dihydroquinoline derivative represented by the general formula (1) below, which has a substituted phenylchalcogeno lower alkyl group and a phenyl group having an ester structure introduced therein as substituents, or a salt of such a derivative. The compound (1) or a salt thereof is useful as a glucocorticoid receptor modulator. In the formula below, R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and represent a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom or a lower alkyl group; R6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group or a nitro group; X represents -C(O)-, -C(O)NR8-, -S(O)2- or the like; R7 and/or R8 may be the same or different and represent a hydrogen atom, an optionally substituted lower alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclic group, an optionally substituted lower alkoxy group or the like; Y represents a lower alkylene group; Z represent a chalcogen atom; and p represents 0, 1, 2 or 3.
Inventors:
MATSUDA MAMORU (JP)
NAGATSUKA MASATO (JP)
MORI TOSHIYUKI (JP)
KOBAYASHI SACHIKO (JP)
KATO MASATOMO (JP)
TAKAI MIWA (JP)
NAGATSUKA MASATO (JP)
MORI TOSHIYUKI (JP)
KOBAYASHI SACHIKO (JP)
KATO MASATOMO (JP)
TAKAI MIWA (JP)
Application Number:
PCT/JP2007/072081
Publication Date:
May 22, 2008
Filing Date:
November 14, 2007
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
MATSUDA MAMORU (JP)
NAGATSUKA MASATO (JP)
MORI TOSHIYUKI (JP)
KOBAYASHI SACHIKO (JP)
KATO MASATOMO (JP)
TAKAI MIWA (JP)
MATSUDA MAMORU (JP)
NAGATSUKA MASATO (JP)
MORI TOSHIYUKI (JP)
KOBAYASHI SACHIKO (JP)
KATO MASATOMO (JP)
TAKAI MIWA (JP)
International Classes:
C07D215/14; A61K31/47; A61K31/4709; A61P1/04; A61P3/04; A61P3/06; A61P3/10; A61P3/14; A61P5/00; A61P9/00; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P25/00; A61P25/18; A61P25/28; A61P27/06; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07D311/80; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D491/052
Domestic Patent References:
WO2007032556A1 | 2007-03-22 | |||
WO2006019716A1 | 2006-02-23 | |||
WO2004018429A2 | 2004-03-04 | |||
WO2006019716A1 | 2006-02-23 |
Foreign References:
JPH10510840A | 1998-10-20 | |||
JP2006504678A | 2006-02-09 | |||
JP2002193955A | 2002-07-10 | |||
JPH10510840A | 1998-10-20 |
Other References:
SOUGOU RINSYOU, vol. 54, no. 7, 2005, pages 1951 - 2076
See also references of EP 2085387A4
See also references of EP 2085387A4
Attorney, Agent or Firm:
HIBI, Norihiko et al. (3rd Floor Inaba Building, 13-18, Nishishinsaibashi 1-chome, Chuo-ku, Osaka-sh, Osaka 86, JP)
Download PDF: