Title:
NOVEL 2-AMINBENZOYL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2016/027757
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel compound for realizing an effect on a therapeutic and/or preventive drug for mental illnesses, such as depression, atypical depression, treatment-resistant depression, anxiety neurosis, bipolar disorder, obsessive-compulsive disorder, and PTSD, for chronic pain symptoms such as fibromyalgia, and for chronic pruritus, such effect due to the conversion of a metabolic structure product which exists in the tryptophan metabolic pathway. The present invention relates to a compound represented by formula (1) or a pharmaceutically acceptable salt thereof, or a hydrate or solvate of the compound or salt, and the medical use of same. [In the formula, Q is the following formulas (2a) through (2c) (where R1 is a hydrogen atom, and the like; R2 and R3 are the same or different and are selected from a hydrogen atom, and the like, or together with carbon atoms that bond therewith, optionally form a 3- to 8-member cycloalkane ring; R4 and R5 are the same or different and are selected from a hydrogen atom, and the like, or together with the nitrogen atoms that bond therewith, optionally form a 3- to 8-member cyclic amine; and n is 0, 1, 2, 3, 4 or 5.)]
Inventors:
TAKAI KENTARO (JP)
MIZUSHIMA SHINGO (JP)
SHIMADA SHOICHI (JP)
YAMAMOTO YUKIKO (JP)
MIZUSHIMA SHINGO (JP)
SHIMADA SHOICHI (JP)
YAMAMOTO YUKIKO (JP)
Application Number:
PCT/JP2015/073002
Publication Date:
February 25, 2016
Filing Date:
August 17, 2015
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C07C225/22; A61K31/137; A61K31/397; A61K31/40; A61K31/4462; A61P25/04; A61P25/18; A61P25/22; A61P25/24; C07D205/04; C07D207/08; C07D211/32
Domestic Patent References:
| WO2013151707A1 | 2013-10-10 | |||
| WO1997015550A1 | 1997-05-01 |
Foreign References:
| US3789072A | 1974-01-29 | |||
| JPH10503525A | 1998-03-31 | |||
| JP2007518673A | 2007-07-12 | |||
| JP2008546651A | 2008-12-25 | |||
| JP2002536434A | 2002-10-29 | |||
| JP2010505816A | 2010-02-25 | |||
| JPH06510023A | 1994-11-10 | |||
| US4093734A | 1978-06-06 |
Other References:
BACK W., ARCHIV DER PHARMAZIE, vol. 303, no. 6, 1970, pages 465 - 470, ISSN: 0376-0367
MAKINO K. ET AL., SCIENCE, vol. 120, 1954, pages 544 - 545, ISSN: 0036-8075
MUELLER P. ET AL., ARCH. PHARM. ( WEINHEIM, vol. 316, no. 8, 1983, pages 707 - 712, ISSN: 0365-6233
PERTZ H. ET AL., PHARM.ACTA HELV., vol. 63, no. 4-5, 1988, pages 128 - 131, ISSN: 0031-6865
MAKINO K. ET AL., SCIENCE, vol. 120, 1954, pages 544 - 545, ISSN: 0036-8075
MUELLER P. ET AL., ARCH. PHARM. ( WEINHEIM, vol. 316, no. 8, 1983, pages 707 - 712, ISSN: 0365-6233
PERTZ H. ET AL., PHARM.ACTA HELV., vol. 63, no. 4-5, 1988, pages 128 - 131, ISSN: 0031-6865
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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