Title:
NOVEL 3-(4-(BENZYLOXY)PHENYL)HEX-4-INOIC ACID DERIVATIVE, METHOD OF PREPARING SAME AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC DISEASE INCLUDING SAME AS EFFECTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2014/171762
Kind Code:
A1
Abstract:
The present invention relates to a novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative, a method of preparing same and a pharmaceutical composition for preventing and treating metabolic disease including same as an effective ingredient. The novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has an excellent effect on activation of GPR40 protein and thus has excellent promoting effect of insulin secretion; is nontoxic when co-administrated with other drugs and is possibly co-administrated with other drugs; and has excellent effective effect of activating GPR40 protein in vivo. Therefore, a composition including the novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof may be availably used in a pharmaceutical composition for preventing and treating metabolic disease such as obesity, type I diabetes, type II diabetes, incompatible glucose tolerance, insulin tolerance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia, syndrome X, etc.
Inventors:
YANG JIN (KR)
KIM JIN WOONG (KR)
LEE HAN KYU (KR)
KIM JAE HYUN (KR)
SON CHANG MO (KR)
LEE KYU HWAN (KR)
CHOI HYUNG-HO (KR)
KIM DAEHOON (KR)
HA TAE-YOUNG (KR)
RHEE JAEKEOL (KR)
KIM JIN WOONG (KR)
LEE HAN KYU (KR)
KIM JAE HYUN (KR)
SON CHANG MO (KR)
LEE KYU HWAN (KR)
CHOI HYUNG-HO (KR)
KIM DAEHOON (KR)
HA TAE-YOUNG (KR)
RHEE JAEKEOL (KR)
Application Number:
PCT/KR2014/003355
Publication Date:
October 23, 2014
Filing Date:
April 17, 2014
Export Citation:
Assignee:
HYUNDAI PHARM CO LTD (KR)
International Classes:
C07D317/72; A61K31/357; A61P3/10
Domestic Patent References:
| WO2008030618A1 | 2008-03-13 | |||
| WO2005086661A2 | 2005-09-22 | |||
| WO2011046851A1 | 2011-04-21 |
Foreign References:
| KR20120051777A | 2012-05-22 | |||
| US20090170908A1 | 2009-07-02 |
Other References:
WALKER, S. D. ET AL.: "Development of a Scalable Synthesis of a GPR40 Receptor Agonist", ORGANIC PROCESS RESEARCH & DEVELOPMENT., vol. 15, no. 3, 27 March 2011 (2011-03-27), pages 570 - 580, XP055286954
CURRENT DRUG TARGETS, vol. 9, 2008, pages 899 - 910
CAN J DIABETES, vol. 36, 2012, pages 275 - 280
CURRENT DRUG TARGETS, vol. 9, 2008, pages 899 - 910
CAN J DIABETES, vol. 36, 2012, pages 275 - 280
Attorney, Agent or Firm:
LEE, Won Hee (Sung-ji Heights II147 Teheran-ro,Kangnam-gu, Seoul 135-910, KR)
Download PDF: