NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE

WIPO Patent Application WO/2011/052756

A1

Disclosed are a GPR40 activator, particularly an insulin secretion promoter, and a prophylactic and/or therapeutic agent for diabetes, obesity, etc. each containing, as an active ingredient, a novel compound having a GPR40 agonistic activity or a salt thereof or a solvate thereof, or the like. Also disclosed is a compound represented by formula (I) or a salt thereof, or a solvate thereof. In formula (I), p represents 0 to 4; j represents 0 to 3; k represents 0 to 2; the ring A represents a specific cyclic group; the ring B represents a benzene ring, a pyridine ring, or a pyrimidine ring; X represents -CH2-, O, -S(O)i- (i represents 0 to 2), or -NR7-; and R1 to R6 each independently represent a specific group.

OKANO AKIHIRO (JP)
OHKOUCHI MUNETAKA (JP)

PCT/JP2010/069380

May 05, 2011

October 29, 2010

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MOCHIDA PHARM CO LTD (JP)
OKANO AKIHIRO (JP)
OHKOUCHI MUNETAKA (JP)

C07D261/12; A61K31/42; A61K31/422; A61K31/4439; A61K31/506; A61P3/10; A61P43/00; C07D413/12

WO2008066131A1	2008-06-05
WO2008030520A1	2008-03-13
WO2009147990A1	2009-12-10
WO2004041266A1	2004-05-21
WO2005086661A2	2005-09-22
WO2007123225A1	2007-11-01
WO2008001931A2	2008-01-03
WO2009054390A1	2009-04-30
WO2009054423A1	2009-04-30
WO2008066131A1	2008-06-05
WO2009147990A1	2009-12-10
WO2005063729A1	2005-07-14
WO1997031906A1	1997-09-04

JPS62175458A

1987-08-01

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See also references of EP 2495238A4

HANABUSA, Tsuneo et al. (JP)
Sepal Tsuneo (JP)

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