Title:
NOVEL 3-PHENYLTETRAHYDROCINNOLIN-5-OL DERIVATIVE AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2005/121105
Kind Code:
A1
Abstract:
A 3-phenyltetrahydrocinnolin-5-ol derivative represented by the following general formula (1) (wherein Z represents 2-carboxyethyl, 3-dimethylaminopropyl, etc.; X represents trifluoromethyl, etc.; X' represents hydrogen, etc.; and Y and Y' each represents methyl, hydrogen, etc.), a physiologically acceptable salt thereof, or a prodrug of either. They have cytostatic activity against tumor cells and hence are effective as an antitumor agent.
Inventors:
SATO YOSHITAKA (JP)
SUZUKI YOSHIKAZU (JP)
YAMAMOTO KEIICHIRO (JP)
KUROIWA SHUNSUKE (JP)
MARUYAMA SAKIKO (JP)
SUZUKI YOSHIKAZU (JP)
YAMAMOTO KEIICHIRO (JP)
KUROIWA SHUNSUKE (JP)
MARUYAMA SAKIKO (JP)
Application Number:
PCT/JP2005/010494
Publication Date:
December 22, 2005
Filing Date:
June 08, 2005
Export Citation:
Assignee:
NIPPON KAYAKU KK (JP)
SATO YOSHITAKA (JP)
SUZUKI YOSHIKAZU (JP)
YAMAMOTO KEIICHIRO (JP)
KUROIWA SHUNSUKE (JP)
MARUYAMA SAKIKO (JP)
SATO YOSHITAKA (JP)
SUZUKI YOSHIKAZU (JP)
YAMAMOTO KEIICHIRO (JP)
KUROIWA SHUNSUKE (JP)
MARUYAMA SAKIKO (JP)
International Classes:
A61K31/502; A61K31/5377; A61P35/00; C07D237/26; C07D237/28; C07D401/12; (IPC1-7): C07D237/26; A61K31/502; A61K31/5377; A61P35/00; C07D401/12
Domestic Patent References:
WO2004052866A1 | 2004-06-24 |
Other References:
NAGARAJAN RK ET AL: "Synthesis and Reactions of 4,6,7,8-Tetrahydro-5 (1H)-cinnolonones.", INDIAN JOURNAL OF CHEMISTRY., vol. 25B, no. 7, 1986, pages 697 - 708, XP002976309
Attorney, Agent or Firm:
Asamura, Kiyoshi (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)
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