Title:
NOVEL 3,5-DIAMINOBENZOIC ACID COMPOUND, AND PIN1 INHIBITOR AND THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/182457
Kind Code:
A1
Abstract:
[Problem] To develop novel compounds having an activity of inhibiting the function of Pin1 so as to use these compounds as pharmaceutical candidate compounds. [Solution] A compound represented by formula (I) or a salt thereof, and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for fatty liver diseases, a therapeutic or prophylactic agent for obesity, and a therapeutic or prophylactic agent for COVID-19, each using the aforesaid compound or a salt thereof.
Inventors:
ASANO TOMOICHIRO (JP)
NAKATSU YUSUKE (JP)
ITO HISANAKA (JP)
OKABE TAKAYOSHI (JP)
NAKATSU YUSUKE (JP)
ITO HISANAKA (JP)
OKABE TAKAYOSHI (JP)
Application Number:
PCT/JP2021/009233
Publication Date:
September 16, 2021
Filing Date:
March 09, 2021
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
TOKYO UNIV OF PHARMACY & LIFE SCIENCES (JP)
UNIV TOKYO (JP)
TOKYO UNIV OF PHARMACY & LIFE SCIENCES (JP)
UNIV TOKYO (JP)
International Classes:
A61K45/00; A61K31/167; A61K31/357; A61K31/403; A61K31/4439; A61K31/47; A61K31/4709; A61K31/497; A61K31/498; A61P1/00; A61P1/16; A61P3/04; A61P3/06; A61P11/00; A61P29/00; A61P43/00; C07C237/20; C07C271/26; C07C275/42; C07D209/82; C07D215/16; C07D241/24; C07D319/20; C07D401/12; C07D403/12; C07D405/12
Domestic Patent References:
| WO2019031472A1 | 2019-02-14 | |||
| WO2019031470A1 | 2019-02-14 | |||
| WO2004087720A1 | 2004-10-14 | |||
| WO2006040646A1 | 2006-04-20 | |||
| WO2005007123A2 | 2005-01-27 | |||
| WO2002060436A2 | 2002-08-08 | |||
| WO2018101329A1 | 2018-06-07 | |||
| WO2019031470A1 | 2019-02-14 | |||
| WO2019031471A1 | 2019-02-14 | |||
| WO2019031472A1 | 2019-02-14 |
Foreign References:
| DE10309005A1 | 2004-09-09 |
Other References:
ANDREW POTTER, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 22, 17 September 2010 (2010-09-17), pages 6483 - 6488
ANDREW POTTER, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 2, 22 November 2009 (2009-11-22), pages 586 - 590
YUSUKE NAKATSUTOMOICHIRO ASANO, THE JOURNAL OF BIOLOGICAL CHEMISTRY (J. BIOL. CHEM., vol. 286, no. 23, 17 March 2011 (2011-03-17), pages 20812 - 20822
LIMING DONG, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (BIOORG. MED. CHEM. LETT., vol. 20, no. 7, 14 February 2010 (2010-02-14), pages 2210 - 2214
YUSUKE NAKATSU, THE JOURNAL OF BIOLOGICALCHEMISTRY (J BIOL CHEM., vol. 287, no. 53, 29 October 2012 (2012-10-29), pages 44526 - 44535
TOMOICHIRO ASANO, JOURNAL OF JAPAN FOUNDATION FOR APPLIED ENZYMOLOGY, no. 48, 1 March 2014 (2014-03-01), pages 39 - 40
HIROKI YAMAZAKI ET AL., JOURNAL OF THE JAPAN DIABETES SOCIETY, vol. 57, 25 April 2014 (2014-04-25)
TOMOICHIRO ASANO: "Novel treatment of inflammatory bowel diseases by Pin1 inhibitors", PRESENTATION FOR THE DSANJ BIZ MEETING CATEGORIZED BY TARGET DISEASES (GASTROINTESTINAL DISEASES, 30 January 2015 (2015-01-30)
YUSUKE NAKATSU ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, no. 40, 2015, pages 24255 - 24266
JANOWSKI ET AL., ANALYTICALBIOCHEMISTRY, vol. 252, 1997, pages 299 - 307
HAILONG ZHAO ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, 2016, pages 5911 - 5920
SHUO WEI ET AL., NATURE MEDICINE, vol. 21, no. 5, 2015, pages 457 - 466
See also references of EP 4119165A4
ANDREW POTTER, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 2, 22 November 2009 (2009-11-22), pages 586 - 590
YUSUKE NAKATSUTOMOICHIRO ASANO, THE JOURNAL OF BIOLOGICAL CHEMISTRY (J. BIOL. CHEM., vol. 286, no. 23, 17 March 2011 (2011-03-17), pages 20812 - 20822
LIMING DONG, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (BIOORG. MED. CHEM. LETT., vol. 20, no. 7, 14 February 2010 (2010-02-14), pages 2210 - 2214
YUSUKE NAKATSU, THE JOURNAL OF BIOLOGICALCHEMISTRY (J BIOL CHEM., vol. 287, no. 53, 29 October 2012 (2012-10-29), pages 44526 - 44535
TOMOICHIRO ASANO, JOURNAL OF JAPAN FOUNDATION FOR APPLIED ENZYMOLOGY, no. 48, 1 March 2014 (2014-03-01), pages 39 - 40
HIROKI YAMAZAKI ET AL., JOURNAL OF THE JAPAN DIABETES SOCIETY, vol. 57, 25 April 2014 (2014-04-25)
TOMOICHIRO ASANO: "Novel treatment of inflammatory bowel diseases by Pin1 inhibitors", PRESENTATION FOR THE DSANJ BIZ MEETING CATEGORIZED BY TARGET DISEASES (GASTROINTESTINAL DISEASES, 30 January 2015 (2015-01-30)
YUSUKE NAKATSU ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, no. 40, 2015, pages 24255 - 24266
JANOWSKI ET AL., ANALYTICALBIOCHEMISTRY, vol. 252, 1997, pages 299 - 307
HAILONG ZHAO ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, 2016, pages 5911 - 5920
SHUO WEI ET AL., NATURE MEDICINE, vol. 21, no. 5, 2015, pages 457 - 466
See also references of EP 4119165A4
Attorney, Agent or Firm:
ISODA Shiro et al. (JP)
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