Title:
NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Document Type and Number:
WIPO Patent Application WO/2016/175555
Kind Code:
A8
Abstract:
The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically cceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori. Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.
Inventors:
LEE CHUN HO (KR)
LEE SEUNG CHUL (KR)
LEE YEON IM (KR)
EOM DEOK KI (KR)
HAN MI RYEONG (KR)
KOH EUN JI (KR)
LEE SEUNG CHUL (KR)
LEE YEON IM (KR)
EOM DEOK KI (KR)
HAN MI RYEONG (KR)
KOH EUN JI (KR)
Application Number:
PCT/KR2016/004411
Publication Date:
September 08, 2017
Filing Date:
April 27, 2016
Export Citation:
Assignee:
DAE WOONG PHARMA (KR)
International Classes:
C07D207/48; A61K31/095; A61K31/40; C07D207/30; C07D207/335; C07D207/36
Attorney, Agent or Firm:
YOU ME PATENT & LAW FIRM (KR)
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