Title:
NOVEL 4-PHENYLAMINO-BENZALDOXIME DERIVATIVE AND USE THEREOF AS MEK INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2005/028426
Kind Code:
A1
Abstract:
A compound of the present invention and pharmaceutically acceptable salts thereof are represented by the following general formula (1). (1) (In the formula (1), the definitions of R1, R2, R3, R4, R5, R6, Q, R8 and R9 are the same as those defined in the description.)
Inventors:
ISSHIKI YOSHIAKI (JP)
KOHCHI YASUNORI (JP)
HATTORI KAZUO (JP)
SHIMMA NOBUO (JP)
MIWA MASANORI (JP)
INAGAKI NAOHITO (JP)
IIKURA HITOSHI (JP)
MATSUBARA YASUAKI (JP)
KOHCHI YASUNORI (JP)
HATTORI KAZUO (JP)
SHIMMA NOBUO (JP)
MIWA MASANORI (JP)
INAGAKI NAOHITO (JP)
IIKURA HITOSHI (JP)
MATSUBARA YASUAKI (JP)
Application Number:
PCT/JP2004/013501
Publication Date:
March 31, 2005
Filing Date:
September 16, 2004
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
ISSHIKI YOSHIAKI (JP)
KOHCHI YASUNORI (JP)
HATTORI KAZUO (JP)
SHIMMA NOBUO (JP)
MIWA MASANORI (JP)
INAGAKI NAOHITO (JP)
IIKURA HITOSHI (JP)
MATSUBARA YASUAKI (JP)
ISSHIKI YOSHIAKI (JP)
KOHCHI YASUNORI (JP)
HATTORI KAZUO (JP)
SHIMMA NOBUO (JP)
MIWA MASANORI (JP)
INAGAKI NAOHITO (JP)
IIKURA HITOSHI (JP)
MATSUBARA YASUAKI (JP)
International Classes:
A61K31/166; A61P1/00; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/08; A61P15/00; A61P17/06; A61P19/02; A61P19/04; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07C259/10; C07C311/04; C07C317/18; C07C323/12; C07D207/08; C07D207/27; C07D211/46; C07D213/30; C07D233/32; C07D233/54; C07D233/64; C07D263/32; C07D295/088; C07D295/155; C07F7/18; C07D207/26; (IPC1-7): C07C259/10; C07C229/58; C07C251/48; C07C311/04; C07C317/18; C07C323/12; C07D207/08; C07D207/26; C07D211/46; C07D213/30; C07D233/34; C07D233/64; C07D295/08; C07F7/18; A61K31/166; A61K45/00; A61P1/00; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/08; A61P15/00; A61P17/06; A61P19/02; A61P19/04; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P37/00; A61P37/06; A61P43/00
Domestic Patent References:
| WO2003051877A1 | 2003-06-26 |
Foreign References:
| JP2003527379A | 2003-09-16 | |||
| JPS59210046A | 1984-11-28 | |||
| US4001420A | 1977-01-04 | |||
| JPS4861448A | 1973-08-28 | |||
| US2967187A | 1961-01-03 |
Other References:
OZAKI K. ET AL.: "Studies on 4(1H)-quinazolinones. 5. Synthesis and antiiflemmatory activity of 4(1H)-quinazolinone derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, no. 5, 1985, pages 568 - 576, XP002984298
HEINTZ M. ET AL.: "Electrosynthesis of aryl carboxylic acids from chlorobenzene derivatives and carbon dioxide", TETRAHEDRON, vol. 44, no. 6, 1988, pages 1631 - 1636, XP000673081
CHRDONNENS L. ET AL.: "Fluorenacenes and fluorenaphthenes. Syntheses in the idenofluorene series. VIII. 3-methyl-, 1,4-dimethyl-, 1,3-dimethyl-, and 1,3,4-trimethyl-cis-fluorenacene", HELVETICA CHIMICA ACTA, vol. 41, 1958, pages 2436 - 2440, XP002903640
See also references of EP 1674452A4
HEINTZ M. ET AL.: "Electrosynthesis of aryl carboxylic acids from chlorobenzene derivatives and carbon dioxide", TETRAHEDRON, vol. 44, no. 6, 1988, pages 1631 - 1636, XP000673081
CHRDONNENS L. ET AL.: "Fluorenacenes and fluorenaphthenes. Syntheses in the idenofluorene series. VIII. 3-methyl-, 1,4-dimethyl-, 1,3-dimethyl-, and 1,3,4-trimethyl-cis-fluorenacene", HELVETICA CHIMICA ACTA, vol. 41, 1958, pages 2436 - 2440, XP002903640
See also references of EP 1674452A4
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 47, JP)
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