Title:
NOVEL 6-SUBSTITUTED OXA- OR AZASTEROID COMPOUND
Document Type and Number:
WIPO Patent Application WO/1995/017417
Kind Code:
A1
Abstract:
A 6-substituted oxa- or azasteroid compound represented by general formula (I), having an excellent aromatase inhibitory activity, and being useful for preventing or treating diseases caused by estrogens, such as mammary cancer, uterus carcinoma, prostatic hypertrophy, and so forth. This compound has an oxygen or nitrogen atom in the steroidal D ring and the 6-position (R1) is substituted by -S-R2 (R2 representing hydrogen, lower alkyl, cyano or acyl), -O-R3 (R3 representing hydrogen, lower alkyl, or acyl), azido or amino.
Inventors:
KOIZUMI NAOYUKI (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
DOGUCHI KOJI (JP)
HONMA SEIJIRO (JP)
NAKAYAMA MITSUYA (JP)
MIEDA MAMORU (JP)
TAKAHASHI HIROO (JP)
SHIBATA KENYU (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
DOGUCHI KOJI (JP)
HONMA SEIJIRO (JP)
NAKAYAMA MITSUYA (JP)
MIEDA MAMORU (JP)
TAKAHASHI HIROO (JP)
SHIBATA KENYU (JP)
Application Number:
PCT/JP1994/002151
Publication Date:
June 29, 1995
Filing Date:
December 20, 1994
Export Citation:
Assignee:
TEIKOKU HORMONE MFG CO LTD (JP)
KOIZUMI NAOYUKI (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
DOGUCHI KOJI (JP)
HONMA SEIJIRO (JP)
NAKAYAMA MITSUYA (JP)
MIEDA MAMORU (JP)
TAKAHASHI HIROO (JP)
SHIBATA KENYU (JP)
KOIZUMI NAOYUKI (JP)
TAKEGAWA SHIGEHIRO (JP)
IWASHITA SHIGEKI (JP)
KAWACHI TOMOKO (JP)
DOGUCHI KOJI (JP)
HONMA SEIJIRO (JP)
NAKAYAMA MITSUYA (JP)
MIEDA MAMORU (JP)
TAKAHASHI HIROO (JP)
SHIBATA KENYU (JP)
International Classes:
C07J73/00; (IPC1-7): C07J73/00; A61K31/56
Domestic Patent References:
| WO1992017489A1 | 1992-10-15 |
Other References:
See also references of EP 0737689A4
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