Title:
NOVEL AMIDE PYRROLE COMPOUNDS AND USE THEREOF IN MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO/2022/143610
Kind Code:
A1
Abstract:
Disclosed are novel amide pyrrole compounds and the use thereof in medicaments, especially the use thereof as a medicament for treating and preventing hepatitis B. In particular, the present invention relates to a compound as represented by general formula (I) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the use thereof as a medicament, especially a medicament for treating and/or preventing hepatitis B.
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Inventors:
ZHANG YINGJUN (CN)
LIU XINCHANG (CN)
REN QINGYUN (CN)
WANG MENG (CN)
JI SHILONG (CN)
YAN GUANGHUA (CN)
LEI DOUXING (CN)
YU GUOSEN (CN)
LIU XINCHANG (CN)
REN QINGYUN (CN)
WANG MENG (CN)
JI SHILONG (CN)
YAN GUANGHUA (CN)
LEI DOUXING (CN)
YU GUOSEN (CN)
Application Number:
PCT/CN2021/141926
Publication Date:
July 07, 2022
Filing Date:
December 28, 2021
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D207/34; A61K31/40; A61P31/20; C07D405/12
Domestic Patent References:
| WO2021197486A1 | 2021-10-07 | |||
| WO2020255013A1 | 2020-12-24 | |||
| WO2018039531A1 | 2018-03-01 | |||
| WO2020205934A1 | 2020-10-08 | |||
| WO2017136403A1 | 2017-08-10 |
Foreign References:
| CN113454077A | 2021-09-28 | |||
| US20200031816A1 | 2020-01-30 | |||
| CN109153640A | 2019-01-04 |
Other References:
LV KAI; WU SHUO; LI WENYAN; GENG YUNHE; WU MENG; ZHOU JINMING; LI YUHUAN; GAO QIANG; LIU MINGLIANG: "Design, synthesis and anti-HBV activity of NVR3-778 derivatives", BIOORGANIC CHEMISTRY, vol. 94, 14 October 2019 (2019-10-14), US , pages 1 - 5, XP085989037, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2019.103363
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