NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC

WIPO Patent Application WO/1996/005174

A1

A novel amine derivative represented by general formula (I) and a salt thereof, both being useful as an antiarrhythmic, wherein (a) represents (b) or (c); A represents -NR8-(CH2)a-(5- or 6-membered nitrogenous heterocycle)- or a 6-membered nitrogenous heterocycle, wherein R8 represents lower alkyl or hydroxylated lower alkyl, and a represents 0 or 1; D represents -(CH2)m-, -(CH2)m-O-, -CO- or -SO2-; R1 and R2 represent each independently hydrogen, halogen, lower alkoxy or lower alkylsulfonylamino; R3 represents lower alkyl; R4, R5, R6 and R7 represent each independently hydrogen or lower alkylsulfonylamino; R represents nitro or lower alkylsulfonylamino; X represents hydrogen or halogen; and m and n represent each an integer of 0 to 3.

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CHUNG YOU SUP (KR)
PARK SUNG DAE (KR)
KWON LAE SUNG (KR)
SHIN HONG SUB (KR)
TANABE SHIGERU (JP)

PCT/JP1995/001134

February 22, 1996

June 07, 1995

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C & C RESEARCH LABS (KR)
CHUNG YOU SUP (KR)
PARK SUNG DAE (KR)
KWON LAE SUNG (KR)
SHIN HONG SUB (KR)
TANABE SHIGERU (JP)

C07D401/06; C07D401/12; (IPC1-7): C07D207/09; A61K31/40; A61K31/445; A61K31/47; A61K31/495; C07D211/56; C07D215/38; C07D295/096; C07D295/135; C07D401/06; C07D401/12

JPH05500660A	1993-02-12
JPS6452756A	1989-02-28
JPH04356462A	1992-12-10
JPS62281858A	1987-12-07
JPH04290878A	1992-10-15

INDIAN J. CHEM., Sect. B, 19B(11), 1003-5 (1980).
INDIAN J. CHEM., Sect. B, 20B(8), 680-2 (1981).

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