Title:
NOVEL ANTI-HUMAN CTGF ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2013/094723
Kind Code:
A1
Abstract:
[Problem] To provide: an anti-human CTGF antibody having a superior binding activity and/or a superior neutralization activity compared with those of conventional anti-human CTGF antibodies; and a means for preventing or treating various diseases in which human CTGF is involved in the formation of clinical conditions thereof, including renal diseases such as chronic kidney disease and diabetic nephropathy, using the above-mentioned anti-human CTGF antibody.
[Solution] An anti-human CTGF antibody containing a heavy-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 10 and a light-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 4.
Inventors:
IWASAKI SHOJI (JP)
MORIYA RYUICHI (JP)
YOSHINO MASAYASU (JP)
TAKAKURA KOJI (JP)
MORIYA RYUICHI (JP)
YOSHINO MASAYASU (JP)
TAKAKURA KOJI (JP)
Application Number:
PCT/JP2012/083206
Publication Date:
June 27, 2013
Filing Date:
December 21, 2012
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
C12N15/09; C07K16/22; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12P21/08
Domestic Patent References:
| WO2007066823A1 | 2007-06-14 | |||
| WO1999033878A1 | 1999-07-08 | |||
| WO2010053751A1 | 2010-05-14 | |||
| WO2004108764A2 | 2004-12-16 | |||
| WO2007066823A1 | 2007-06-14 | |||
| WO1990000786A1 | 1990-01-25 | |||
| WO1994020632A1 | 1994-09-15 |
Foreign References:
| JP2007525194A | 2007-09-06 | |||
| JP2004524841A | 2004-08-19 | |||
| JP2002532082A | 2002-10-02 | |||
| JP2000232884A | 2000-08-29 | |||
| US6596541B2 | 2003-07-22 |
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BLOM IE ET AL., MATRIX BIOL., vol. 21, no. 6, 2002, pages 473 - 82
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ZHANG ET AL., KIDNEY INTERNATIONAL, vol. 56, 1999, pages 549 - 558
YAMAMOTO; WILSON, KIDNEY INT., vol. 32, 1987, pages 514 - 25
MORITA ET AL., AM J KIDNEY DIS, vol. 31, 1998, pages 559 - 73
FLOEGE ET AL., KIDNEY INT., vol. 40, 1991, pages 477 - 88
ITO ET AL., J AM SOC NEPHROL., vol. 12, 2001, pages 472 - 84
KASUGA ET AL., KIDNEY INT., vol. 60, 2001, pages 1745 - 55
LIU ET AL., NEPHRON EXP NEPHROL., vol. 105, 2007, pages E65 - 74
A. IGARASHI ET AL., MOL. BIOL. CELL, vol. 4, 1993, pages 637 - 645
BLOM IE ET AL., MATRIX BIOL., vol. 21, no. 6, 2002, pages 473 - 82
ABREU ET AL., NAT. CELL. BIOL., vol. 4, 2002, pages 599 - 604
ITO Y ET AL., KIDNEY INT., vol. 53, no. 4, 1998, pages 853 - 61
PHANISH MK ET AL., NEPHRON EXP NEPHROL., vol. 114, no. 3, 2010, pages E83 - 92
SHI-WEN X ET AL., CYTOKINE GROWTH FACTOR REV., vol. 19, no. 2, 2008, pages 133 - 44
JUN JI ET AL., NAT REV DRUG DISCOV., vol. 10, no. 12, 2011, pages 945 - 63
SCIENCE, vol. 122, 1952, pages 501
VIROLOGY, vol. 8, 1959, pages 396
J. AM. MED. ASSOC., vol. 199, 1967, pages 519
PROC. SOC. EXP. BIOL. MED., vol. 3, 1950, pages 1
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 8404
MILLER ET AL.: "Exp. Mol. Genet", 1972, COLD SPRING HARBOR LABORATORY, pages: 431
BOSTIAN, PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4505
J IMMUNOL., vol. 148, no. 4, 1992, pages 1149 - 1154
ZHANG ET AL., KIDNEY INTERNATIONAL, vol. 56, 1999, pages 549 - 558
YAMAMOTO; WILSON, KIDNEY INT., vol. 32, 1987, pages 514 - 25
MORITA ET AL., AM J KIDNEY DIS, vol. 31, 1998, pages 559 - 73
FLOEGE ET AL., KIDNEY INT., vol. 40, 1991, pages 477 - 88
ITO ET AL., J AM SOC NEPHROL., vol. 12, 2001, pages 472 - 84
KASUGA ET AL., KIDNEY INT., vol. 60, 2001, pages 1745 - 55
LIU ET AL., NEPHRON EXP NEPHROL., vol. 105, 2007, pages E65 - 74
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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