Title:
NOVEL ANTI-TIE2 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/098080
Kind Code:
A1
Abstract:
The present invention relates to a novel anti-Tie2 antibody or an antigen-binding fragment thereof, and use thereof. The present invention provides an antibody or an antigen-binding fragment thereof, comprising: at least one heavy chain variable region including CDR1-H having an amino acid sequence of X1-X2-X3-X4-X5-X6-Y-X7-M-H-W-X8 (in the amino acid sequence, X1 to X8 are each independently any amino acid); and at least one light chain variable region including CDR1-L having an amino acid sequence of X17-X18-X19-X20-X21-X22-X23-N-X24-X25-X26-Y (in the amino acid sequence, X17 to X20 and X22 to X26 are each independently any amino acid, and X21 is any one selected from the group consisting of tyrosine, phenylalanine, and tryptophan. The antibody or the antigen-binding fragment thereof, according to the present invention, specifically binds to a human or monkey Tie2 protein, thus having the activity of phosphorylating same, while exhibiting a much superior effect in terms of antigen specificity or affinity, compared to existing ligands or antibodies, and is a fully human antibody, and thus can be applied as an active ingredient of a pharmaceutical composition for humans without the fear of rejection. Thus, the antibody or the antigen-binding fragment thereof has the advantage of being effectively used in the treatment or prevention of angiogenesis-related diseases.
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Inventors:
MIN JEONG KI (KR)
LEE DONG GWANG (KR)
LEE NAM-KYUNG (KR)
PARK JONG GIL (KR)
HWANG BYUNGTAE (KR)
KIM SUNG SIK (KR)
LEE JANGWOOK (KR)
LEE JAEMIN (KR)
LEE DONG GWANG (KR)
LEE NAM-KYUNG (KR)
PARK JONG GIL (KR)
HWANG BYUNGTAE (KR)
KIM SUNG SIK (KR)
LEE JANGWOOK (KR)
LEE JAEMIN (KR)
Application Number:
PCT/KR2021/015786
Publication Date:
May 12, 2022
Filing Date:
November 03, 2021
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C07K16/28; A61K39/00; A61P9/10; A61P15/10; A61P27/02; A61P35/00
Foreign References:
| KR20190139148A | 2019-12-17 | |||
| US20060057138A1 | 2006-03-16 | |||
| KR20170029508A | 2017-03-15 |
Other References:
DATABASE PROTEIN 7 July 2013 (2013-07-07), ANONYMOUS : "immunoglobulin A heavy chain variable region. partial [Homo sapiens]", XP055928949, retrieved from NCBI Database accession no. AGP01910
DATABASE PROTEIN 11 July 2018 (2018-07-11), ANONYMOUS : "immunoglobulin light chain variable region, partial [Homo sapiens]", XP055928955, retrieved from NCBI Database accession no. AXA12665
DATABASE PROTEIN 11 July 2018 (2018-07-11), ANONYMOUS : "immunoglobulin light chain variable region, partial [Homo sapiens]", XP055928955, retrieved from NCBI Database accession no. AXA12665
Attorney, Agent or Firm:
BAE, KIM & LEE IP (KR)
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