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Title:
NOVEL ANTIBACTERIAL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2013/115619
Kind Code:
A2
Abstract:
The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof exhibiting antibacterial activity, an extract comprising the compound from a Penicillium sp. strain, a fraction of the extract, an antibacterial composition comprising the compound or the pharmaceutically acceptable salt thereof as an active ingredient, a pharmaceutical composition for treating food poisoning, a pharmaceutical composition for preventing or treating pyogenic infection, a method of treating food poisoning or pyogenic infection comprising a step of administering the composition, a composition for suppressing the activity of FabI which is an enoyl-ACP reductase, and a method of preparing the compound. The compound of the present invention can be widely used for the development of a medicine to treat food poisoning and pyogenic infection, since the compound exhibits the antibacterial activity of suppressing the growth of Bacillus and Staphylococcus aureus, which cause food poisoning or pyogenic infection, by suppressing the activity of enoyl-ACP reductase.

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Inventors:
KIM WON GON (KR)
KIM NYUNG (KR)
SOHN MI JIN (KR)
Application Number:
PCT/KR2013/000879
Publication Date:
August 08, 2013
Filing Date:
February 04, 2013
Export Citation:
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Assignee:
KOREA RES INST OF BIOSCIENCE (KR)
International Classes:
C07D407/04; A61K31/352; A61P31/04; C07D311/86
Domestic Patent References:
WO2006007310A22006-01-19
WO2002066467A12002-08-29
Foreign References:
US20050085413A12005-04-21
US5641804A1997-06-24
Other References:
KIM, NYOUNG ET AL.: 'Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375' BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 22, 2012, pages 2503 - 2506
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
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