NOVEL ANTIBIOTIC, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUG COMPOSITION CONTAINING THE SAME

Title:

NOVEL ANTIBIOTIC, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUG COMPOSITION CONTAINING THE SAME

Document Type and Number:

WIPO Patent Application WO/1997/038005

Kind Code:

A1

Abstract:

An antifungal and antilipemic agent comprising substance MK6059 of the following general formula (I) which is prepared by culturing a MK6059 strain belonging to the genus Ellisiodothis in a conventional nutrient medium for microbes, and subjecting the resulting system to extraction with solvent, ion exchange, silica gel chromatography, gel filtration chromatography or the like to isolate the objective substance.

Inventors:

HARIMAYA KENZO (JP)
SATO YOSHIKAZU (JP)
KONNO FUKIO (JP)
SASAKI TORU (JP)
KANDA MINA (JP)
CHIBA NORIKO (JP)
MIKAWA TAKASHI (JP)

Application Number:

PCT/JP1997/001221

Publication Date:

October 16, 1997

Filing Date:

April 09, 1997

Export Citation:

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Assignee:

MEIJI SEIKA KAISHA (JP)
MITSUBISHI CHEM CORP (JP)
HARIMAYA KENZO (JP)
SATO YOSHIKAZU (JP)
KONNO FUKIO (JP)
SASAKI TORU (JP)
KANDA MINA (JP)
CHIBA NORIKO (JP)
MIKAWA TAKASHI (JP)

International Classes:

C07J17/00; C12P33/00; (IPC1-7): C07J9/00; A61K31/56; C12P33/00

Domestic Patent References:

WO1996035432A1

1996-11-14

Foreign References:

US5521169A

1996-05-28

Other References:

J. ANTIBIOT., Vol. 49, No. 6, (June 1996), J.E. LEET et al., "Ascosteroside, a New Antifungal Agent from Ascotricha Amphitricha II. Isolation and Structure Elucidation".
J. ANTIBIOT., Vol. 49, No. 6, (June 1996), J.A. GORMAN et al., "Ascosteroside, a New Antifungal Agent from Ascotricha Amphitricha I. Taxonomy, Fermentation and Biological Activities".

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