Title:
NOVEL ANTIBODY-CYTOKINE FUSION PROTEIN, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/061005
Kind Code:
A1
Abstract:
Provided is a novel antibody-cytokine fusion protein. Further provided are a bispecific molecule and an immunoconjugate comprising the antibody-cytokine fusion protein, as well as a nucleic acid molecule encoding the antibody-cytokine fusion protein, and a vector and a host cell comprising the nucleic acid molecule. Also provided are a method for preparing the antibody-cytokine fusion protein, a pharmaceutical composition containing the antibody-cytokine fusion protein, and a method and a use of the antibody-cytokine fusion protein or the pharmaceutical composition thereof in treating diseases.
Inventors:
LI JOHN YUEHUA (CN)
Application Number:
PCT/CN2022/109997
Publication Date:
April 20, 2023
Filing Date:
August 03, 2022
Export Citation:
Assignee:
LATTICON SUZHOU BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07K19/00; A61K38/20; A61K47/68; A61P35/00; A61P37/02; C07K1/107; C07K14/55
Foreign References:
| CN109071648A | 2018-12-21 | |||
| US20170081382A1 | 2017-03-23 | |||
| CN101166823A | 2008-04-23 | |||
| CN102199218A | 2011-09-28 | |||
| CN110256583A | 2019-09-20 |
Other References:
ROJAS, G. ET AL.: "Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: A versatile platform for fine epitope mapping", IMMUNOBIOLOGY, vol. 218, no. 1, 31 December 2013 (2013-12-31), XP055336251, DOI: 10.1016/j.imbio.2012.02.009
JAKUB TOMALA, JIRINA KOVAROVA, MARTINA KABESOVA, PETRA VOTAVOVA, HELENA CHMELOVA, BARBORA DVORAKOVA, BLANKA RIHOVA, MAREK KOVAR: "Chimera of IL-2 Linked to Light Chain of anti-IL-2 mAb Mimics IL-2/anti-IL-2 mAb Complexes Both Structurally and Functionally", ACS CHEMICAL BIOLOGY, vol. 8, no. 5, 17 May 2013 (2013-05-17), pages 871 - 876, XP055369414, ISSN: 1554-8929, DOI: 10.1021/cb3007242
LETOURNEAU, S. ET AL.: "IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25.", PNAS, vol. 107, no. 5, 2 February 2010 (2010-02-02), XP055182715, DOI: 10.1073/pnas.0909384107
KRIEG, C. ET AL.: "Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells", PNAS, vol. 107, no. 26, 29 June 2010 (2010-06-29), XP002738483, DOI: 10.1073/pnas.1002569107
JAKUB TOMALA, JIRINA KOVAROVA, MARTINA KABESOVA, PETRA VOTAVOVA, HELENA CHMELOVA, BARBORA DVORAKOVA, BLANKA RIHOVA, MAREK KOVAR: "Chimera of IL-2 Linked to Light Chain of anti-IL-2 mAb Mimics IL-2/anti-IL-2 mAb Complexes Both Structurally and Functionally", ACS CHEMICAL BIOLOGY, vol. 8, no. 5, 17 May 2013 (2013-05-17), pages 871 - 876, XP055369414, ISSN: 1554-8929, DOI: 10.1021/cb3007242
LETOURNEAU, S. ET AL.: "IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25.", PNAS, vol. 107, no. 5, 2 February 2010 (2010-02-02), XP055182715, DOI: 10.1073/pnas.0909384107
KRIEG, C. ET AL.: "Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells", PNAS, vol. 107, no. 26, 29 June 2010 (2010-06-29), XP002738483, DOI: 10.1073/pnas.1002569107
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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