Title:
NOVEL ARYL ETHANE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/004065
Kind Code:
A1
Abstract:
The present invention relates to an aryl ethane derivative, for inhibiting an estrogen-related receptor gamma (ERRγ) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.
Inventors:
HWANG SUNG YEOUN (KR)
CHO SUNG JIN (KR)
KIM JINA (KR)
CHIN JUNGWOOK (KR)
HWANG HAYOUNG (KR)
LEE IN-KYU (KR)
JEON YONG-HYUN (KR)
LEE JAETAE (KR)
JEON JAE-HAN (KR)
KIM SANG WOOK (KR)
CHO SUNG JIN (KR)
KIM JINA (KR)
CHIN JUNGWOOK (KR)
HWANG HAYOUNG (KR)
LEE IN-KYU (KR)
JEON YONG-HYUN (KR)
LEE JAETAE (KR)
JEON JAE-HAN (KR)
KIM SANG WOOK (KR)
Application Number:
PCT/KR2016/010364
Publication Date:
January 04, 2018
Filing Date:
September 13, 2016
Export Citation:
Assignee:
KOREA BIO MEDICAL SCIENCE INST (KR)
HWANG SUNG YEOUN (KR)
HWANG SUNG YEOUN (KR)
International Classes:
C07D203/08; A61K31/396; A61K31/397; A61K31/496; A61K31/535; C07D265/28
Domestic Patent References:
| WO2001036360A1 | 2001-05-25 |
Foreign References:
| KR20150035432A | 2015-04-06 | |||
| US20080255089A1 | 2008-10-16 |
Other References:
KIM, J. ET AL.: "Synthesis and Biological Evaluation of Novel 4-hydroxytamoxifen Analogs as Estrogen-related Receptor Gamma Inverse Agonists", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 120, 9 May 2016 (2016-05-09), pages 338 - 352, XP029618927
SINGH, T. D. ET AL.: "Inverse Agonist of Estrogen-related Receptor y Enhances Sodium Iodide Symporter Function through Mitogen-activated Protein Kinase Signaling in Anaplastic Thyroid Cancer Cells", THE JOURNAL OF NUCLEAR MEDICINE, vol. 56, no. 11, 2015, pages 1690 - 1696, XP055558605
ABDELLATIF, K. R. A. ET AL.: "Design, Synthesis and Biological Evaluation of Novel Triaryl (Z)-olefins as Tamoxifen Analogues", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 17, 2013, pages 4960 - 4963, XP028690068
CHEN X; MURAWSKI A ET AL., PHARMACEUTICAL RESEARCH, vol. 25, 2007, pages 1511
See also references of EP 3480186A4
SINGH, T. D. ET AL.: "Inverse Agonist of Estrogen-related Receptor y Enhances Sodium Iodide Symporter Function through Mitogen-activated Protein Kinase Signaling in Anaplastic Thyroid Cancer Cells", THE JOURNAL OF NUCLEAR MEDICINE, vol. 56, no. 11, 2015, pages 1690 - 1696, XP055558605
ABDELLATIF, K. R. A. ET AL.: "Design, Synthesis and Biological Evaluation of Novel Triaryl (Z)-olefins as Tamoxifen Analogues", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 17, 2013, pages 4960 - 4963, XP028690068
CHEN X; MURAWSKI A ET AL., PHARMACEUTICAL RESEARCH, vol. 25, 2007, pages 1511
See also references of EP 3480186A4
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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