Title:
NOVEL AURORA KINASE INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/110009
Kind Code:
A1
Abstract:
Disclosed are a class of novel pyridine compounds, a preparation method therefor and a use thereof. Specifically, disclosed is a compound represented by formula (1), a preparation method therefor, and a use of the formula (1) compound and a pharmaceutically acceptable salt or ester thereof as an aurora kinase inhibitor in the preparation of an anti-tumor drug.
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Inventors:
XIE YULI (CN)
FAN HOUXING (CN)
QIAN LIHUI (CN)
FAN HOUXING (CN)
QIAN LIHUI (CN)
Application Number:
PCT/CN2020/133235
Publication Date:
June 10, 2021
Filing Date:
December 02, 2020
Export Citation:
Assignee:
WIGEN BIOMEDICINE TECH SHANGHAI CO LTD (CN)
International Classes:
C07D417/14; A61K31/454; A61P35/00; C07D401/14
Domestic Patent References:
| WO2009104802A1 | 2009-08-27 | |||
| WO2008026768A1 | 2008-03-06 | |||
| WO2016077161A1 | 2016-05-19 |
Foreign References:
| CN107108567A | 2017-08-29 | |||
| CN104159893A | 2014-11-19 | |||
| CN101103017A | 2008-01-09 | |||
| CN101405282A | 2009-04-08 | |||
| CN109476653A | 2019-03-15 | |||
| CN201911256773A | 2019-12-03 |
Other References:
NATALYA I. VASILEVICH, ELENA A. AKSENOVA, DENIS N. KAZYULKIN, ILYA I. AFANASYEV: "General Ser/Thr Kinases Pharmacophore Approach for Selective Kinase Inhibitors Search as Exemplified by Design of Potent and Selective Aurora A Inhibitors.", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 88, no. 1, 30 January 2016 (2016-01-30), pages 54 - 65, XP055598572, ISSN: 1747-0277, DOI: 10.1111/cbdd.12733
CANCER METASTASIS REV, vol. 22, 2003, pages 451
NAT. REV. CANCER, vol. 5, 2005, pages 42
MOL. CANCER THER., vol. 8, 2009, pages 2046 - 2056
PROC NATL ACAD SCI USA, vol. 99, no. 24, 2002, pages 15440 - 15445
J. CELL SCI., vol. 120, 2007, pages 2987
J. CLIN. PATHOL., vol. 60, no. 2, 2007, pages 218 - 221
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", vol. A, B, 2000, PLENUM
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
CANCER METASTASIS REV, vol. 22, 2003, pages 451
NAT. REV. CANCER, vol. 5, 2005, pages 42
MOL. CANCER THER., vol. 8, 2009, pages 2046 - 2056
PROC NATL ACAD SCI USA, vol. 99, no. 24, 2002, pages 15440 - 15445
J. CELL SCI., vol. 120, 2007, pages 2987
J. CLIN. PATHOL., vol. 60, no. 2, 2007, pages 218 - 221
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", vol. A, B, 2000, PLENUM
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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