Title:
NOVEL BCL10 POLYMERIZATION INHIBITOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/001495
Kind Code:
A1
Abstract:
The present invention provides a novel Bcl10 polymerization inhibitor and an application thereof. The Bcl10 polymerization inhibitor is polypeptide, and has (i) a function of inhibiting Bcl10 polymerization; (ii) the activity of inhibiting a CBM complex; (iii) the activity of selectively inhibiting the growth of a B cell lymphoma (such as ABC-DLBCL); and/or (iv) the activity of preventing and/or treating CBM complex-mediated diseases associated with NF-kB activation. The present invention further provides a preparation method for the polypeptide and an application thereof, and a pharmaceutical composition comprising the polypeptide.
Inventors:
YANG CHENGHUA (CN)
ZHANG LIANG (CN)
SUN CHENXIA (CN)
BAO WEI (CN)
YU HAOLAN (CN)
ZHANG LIANG (CN)
SUN CHENXIA (CN)
BAO WEI (CN)
YU HAOLAN (CN)
Application Number:
PCT/CN2019/093094
Publication Date:
January 02, 2020
Filing Date:
June 26, 2019
Export Citation:
Assignee:
SHANGHAI INST BIOLOGICAL SCIENCES CAS (CN)
International Classes:
C07K19/00; A61K38/16; A61P35/02; C12N15/62; G01N33/50
Foreign References:
| CN105920582A | 2016-09-07 |
Other References:
DANIELA, M. ET AL.: "Generation and Functional Characterization of a BCL10-inhibitory Peptide That Represses NF-kappaB Activation", BIOCHEM. J., vol. 422, no. 3, 15 September 2009 (2009-09-15), pages 553 - 561, XP055670013, ISSN: 0264-6021, DOI: 10.1042/BJ20090055
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF:
Previous Patent: DIARYLETHENE COMPOUND AND PREPARATION AND USE THEREOF
Next Patent: EFFICIENT PREPARATION METHOD FOR EXPANDED SHAG
Next Patent: EFFICIENT PREPARATION METHOD FOR EXPANDED SHAG