NOVEL BENZODIAZEPINE DERIVATIVE

WIPO Patent Application WO/1995/018110

A1

A benzodiazepine derivative represented by general formula (I) and a pharmaceutically acceptable salt thereof, wherein R1 represents a single bond, -CH2-, -CH2O-, -OCH2-, -SCH2- or (a); R2 represents lower alkyl, -COOR5, -CONH(CH2)nCOOR5, -CONHSO2R5, -SO2NHCOR5 or optionally substituted heterocyclic group, (wherein R5 represents hydrogen, lower alkyl or benzyl; and n represents an integer of 1 to 5); R3 represents a single bond, -CO- or -CONH; and R4 represents optionally substituted heterocylic group, optionally substituted lower alkyl, optionally substituted lower cycloalkyl, optionally substituted aryl, or lower alkoxycarbonyl. This compound has a high affinity for gastrin receptors and/or CCK-B receptors but not for CCK-A receptors, so that it is useful for curing diseases associated with gastrin receptors and/or CCK-B receptors without inducing the side effects associated with CCK-A receptors.

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HAGISHITA SANJI (JP)
KAMATA SUSUMU (JP)
SENO KAORU (JP)
HAGA NOBUHIRO (JP)
ISHIHARA YASUNOBU (JP)

PCT/JP1994/002132

July 06, 1995

December 19, 1994

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SHIONOGI & CO (JP)
HAGISHITA SANJI (JP)
KAMATA SUSUMU (JP)
SENO KAORU (JP)
HAGA NOBUHIRO (JP)
ISHIHARA YASUNOBU (JP)

C07D243/12; C07D403/12; C07D403/14; C07D405/14; C07D409/14; C07D413/12; C07D417/14; (IPC1-7): C07D243/12; A61K31/55

EP0558104A1

1993-09-01

See also references of EP 0728748A4

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