NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS

Title:

NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/2005/082874

Kind Code:

A1

Abstract:

It is intended to provide a drug useful as a remedy and a preventive for hyperlipemia; a drug also useful as a remedy and a preventive for liver disorders accompanying bile stasis, in particular, primary biliary cirrhosis, primary sclerotic cholantitis and so on; and a drug useful as a remedy and a preventive for obesity, fatty liver and fatty hepatitis. A benzothiazepine or benzothiepine compound represented by the following general formula (1A) which has a thioamide bond and a quaternary ammonium substituent.

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Inventors:

SASAHARA TAKEHIKO (JP)
MOHRI MITSUNOBU (JP)
KASAHARA KEN-ICHI (JP)

Application Number:

PCT/JP2005/003686

Publication Date:

September 09, 2005

Filing Date:

February 25, 2005

Export Citation:

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Assignee:

ASAHI KASEI PHARMA CORP (JP)
SASAHARA TAKEHIKO (JP)
MOHRI MITSUNOBU (JP)
KASAHARA KEN-ICHI (JP)

International Classes:

A61K31/22; A61K31/366; A61K31/38; A61K31/381; A61K31/395; A61K31/4025; A61K31/428; A61K31/439; A61K31/4995; A61K31/5375; A61K31/541; A61K31/554; A61P1/16; A61P3/04; A61P3/06; A61P9/10; C07D281/10; C07D285/36; C07D337/08; C07D409/12; C07D453/02; C07D471/08; C07D487/08; (IPC1-7): C07D281/10; A61K31/22; A61K31/366; A61K31/38; A61K31/381; A61K31/395; A61K31/4025; A61K31/428; A61K31/439; A61K31/4995; A61K31/5375; A61K31/541; A61K31/554; A61P1/16; A61P3/04; A61P3/06; A61P9/10; C07D337/08; C07D409/12; C07D453/02; C07D471/08; C07D487/08

Domestic Patent References:

WO2002008211A2	2002-01-31
WO2002050051A1	2002-06-27
WO2004020421A1	2004-03-11

Foreign References:

JP2002519418A	2002-07-02
JP2002536440A	2002-10-29
JP2002541248A	2002-12-03
JP2002533413A	2002-10-08

Other References:

TELFORD D.E. ET AL: "Inhibition of both the apical sodium-dependent bile acid transporter and HMG CoA reductase markedly enhances the clearance of LDL apoB.", J.LIPID RES.,, vol. 44, no. 5, 2003, pages 943 - 952, XP002989164

Attorney, Agent or Firm:

Sakai, Hiroaki (Kasumigaseki Building 2-5, Kasumigaseki 3-chom, Chiyoda-ku Tokyo, JP)

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