Title:
NOVEL BERBERINE ANALOGUE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/214836
Kind Code:
A1
Abstract:
The present invention relates to a novel berberine analogue CD1-410. It has been identified that the novel berberine analogue promotes the activity of mitophagy, and thus can reduce mitochondria with a damaged structure and/or function. Therefore, the novel berberine analogue according to the present invention can be used for preventing, alleviating and/or treating various diseases that can be caused by abnormal mitochondria.
Inventors:
CHO JONG-HYUN (KR)
YUN JEANHO (KR)
CHOI SEMYEONG (KR)
KIM YOUNG YEON (KR)
YUN JEANHO (KR)
CHOI SEMYEONG (KR)
KIM YOUNG YEON (KR)
Application Number:
PCT/KR2023/006144
Publication Date:
November 09, 2023
Filing Date:
May 04, 2023
Export Citation:
Assignee:
ALTMEDICAL CO LTD (KR)
UNIV DONG A RES FOUND FOR IND ACAD COOP (KR)
UNIV DONG A RES FOUND FOR IND ACAD COOP (KR)
International Classes:
C07D491/147; A23L33/10; A61K31/4741; A61P25/28
Domestic Patent References:
| WO2021198786A1 | 2021-10-07 |
Foreign References:
| KR20210000682A | 2021-01-05 |
Other References:
LEE, G.E. ; LEE, H.S. ; LEE, S.D. ; KIM, J.H. ; KIM, W.K. ; KIM, Y.C.: "Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X"7 antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 19, no. 3, 1 February 2009 (2009-02-01), Amsterdam NL , pages 954 - 958, XP025893606, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2008.11.088
LIANG S"; ZHENG Y; LEI L; DENG X; AI J; LI Y; ZHANG T; MEI Z;" REN Y: "Corydalis edulis total alkaloids (CETA) ameliorates cognitive dysfunction in rat model of Alzheimer disease through regulation of the antioxidant stress and MAP2/NF-κB", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, 1 February 2020 (2020-02-01), IE , pages 112540 - 112540, XP018536800, ISSN: 0378-8741
IWASA K ET AL: "In vitro cytotoxicity of the protoberberine-type alkaloids.", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 7, 1 July 2001 (2001-07-01), US , pages 896 - 898, XP002462488, ISSN: 0163-3864, DOI: 10.1021/np000554f
LIANG S"; ZHENG Y; LEI L; DENG X; AI J; LI Y; ZHANG T; MEI Z;" REN Y: "Corydalis edulis total alkaloids (CETA) ameliorates cognitive dysfunction in rat model of Alzheimer disease through regulation of the antioxidant stress and MAP2/NF-κB", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, 1 February 2020 (2020-02-01), IE , pages 112540 - 112540, XP018536800, ISSN: 0378-8741
IWASA K ET AL: "In vitro cytotoxicity of the protoberberine-type alkaloids.", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 7, 1 July 2001 (2001-07-01), US , pages 896 - 898, XP002462488, ISSN: 0163-3864, DOI: 10.1021/np000554f
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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