Title:
NOVEL BH3 MIMETIC PEPTIDE ANALOG INHIBITING PTP1B ACTIVITY AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/134395
Kind Code:
A9
Abstract:
Disclosed are a novel BH3 mimetic peptide analog inhibiting PTP1B activity and an application thereof. The structural formula (I) of the novel BH3 mimetic peptide analog is as shown below. The mimetic peptide compound is derived from the core region of the Bim-BH3 domain and is prepared by using a solid-phase peptide synthesis method, and the amino acids in the structure thereof are all natural amino acids. The novel BH3 mimetic peptide analog has significant PTP1B-inhibiting activity, and has potential application value in the drug development of related diseases that target PTP1B, such as diabetes, cancer, and Alzheimer's disease.
Inventors:
ZHANG CHUANLIANG (CN)
SU XIANBIN (CN)
HUANG DINGMIN (CN)
WANG ZHENWEI (CN)
SU XIANBIN (CN)
HUANG DINGMIN (CN)
WANG ZHENWEI (CN)
Application Number:
PCT/CN2021/087669
Publication Date:
November 24, 2022
Filing Date:
April 16, 2021
Export Citation:
Assignee:
QINGDAO UNIV OF SCIENCE AND TECHNOLOGY (CN)
International Classes:
C07K14/47; A61K38/17; A61P3/10; A61P25/28; A61P35/00; C07K1/04; C07K1/06; C07K1/20
Attorney, Agent or Firm:
BEIJING DONGFANGSHENGFAN IP AGENCY CO., LTD. (CN)
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