Title:
NOVEL BIPHENYL DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/228286
Kind Code:
A1
Abstract:
The present invention relates to the field of medicinal chemistry, and disclosed are a class of biphenyl derivatives having PD-1/PD-L1 inhibitory activity, a preparation method therefor and a use thereof. Further disclosed are a composition comprising the biphenyl derivative having PD-1/PD-L1 inhibitory activity or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, and an application thereof in the preparation of PD-1/PD-L1 inhibitors. The compounds of the present invention are useful for treating tumors.
Inventors:
XU YUNGEN (CN)
ZHANG HONGBO (CN)
ZHU QIHUA (CN)
DU HUIJIE (CN)
XIA YU (CN)
YU CHUNQIU (CN)
HUANG SHIHUI (CN)
LI HUI (CN)
ZOU YI (CN)
ZHANG HONGBO (CN)
ZHU QIHUA (CN)
DU HUIJIE (CN)
XIA YU (CN)
YU CHUNQIU (CN)
HUANG SHIHUI (CN)
LI HUI (CN)
ZOU YI (CN)
Application Number:
PCT/CN2022/088339
Publication Date:
November 03, 2022
Filing Date:
April 22, 2022
Export Citation:
Assignee:
XIAN XINTONG PHARMACEUTICAL RES CO LTD (CN)
International Classes:
C07D401/12; A61K31/4192; A61K31/4439; A61K31/4545; A61P35/00; C07D249/04; C07D401/14; C07D403/14
Domestic Patent References:
| WO2018045142A1 | 2018-03-08 | |||
| WO2015034820A1 | 2015-03-12 |
Foreign References:
| CN113135895A | 2021-07-20 | |||
| CN113461668A | 2021-10-01 | |||
| CN110799509A | 2020-02-14 | |||
| CN105705489A | 2016-06-22 | |||
| CN109863146A | 2019-06-07 |
Other References:
CLINICAL AND TRANSLATIONAL ONCOLOGY, vol. 21, 2019, pages 702 - 712
THE ONCOLOGIST, vol. 24, 2019, pages S31 - S41
HUMAN VACCINES & IMMUNOTHERAPEUTICS, vol. 10, no. 11, 2014, pages 3111 - 6
JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 22, 2020, pages 13825 - 13850
ZHANGPENG: "Values in the literature: 30-31°C", JOURNAL OF MEDICINAL CHEMISTRY, vol. V53, no. 16, 2010, pages 6112 - 6121
THE ONCOLOGIST, vol. 24, 2019, pages S31 - S41
HUMAN VACCINES & IMMUNOTHERAPEUTICS, vol. 10, no. 11, 2014, pages 3111 - 6
JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 22, 2020, pages 13825 - 13850
ZHANGPENG: "Values in the literature: 30-31°C", JOURNAL OF MEDICINAL CHEMISTRY, vol. V53, no. 16, 2010, pages 6112 - 6121
Attorney, Agent or Firm:
RUNWEN PATENT LAW FIRM (CN)
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