NOVEL BIPHENYL DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE

Title:

NOVEL BIPHENYL DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE

Document Type and Number:

WIPO Patent Application WO/1987/007605

Kind Code:

A1

Abstract:

Biphenyl derivatives represented by formula (I), process for their preparation, liver trouble-relieving agents containing the derivatives as effective ingredients, and intermediates represented by formula (II) for preparing the derivatives. The compounds of the formula (I) are prepared by reacting an alkyl gallate with a methylating agent, halogenating the product, mono-dehalogenating the product to prepare the intermediate (II), methylating it, coupling the product according to the Ullmann reaction, and reacting the product with lead tetraacetate, wherein R1 and R2 each represents H or CH3, and X represents a halogen atom.

Inventors:

MATSUOKA YOSHIYUKI (JP)
HOSAKA KUNIO (JP)
TAKEDA SHIGEHUMI (JP)
MITSUHASHI HIROSHI (JP)

Application Number:

PCT/JP1987/000387

Publication Date:

December 17, 1987

Filing Date:

June 13, 1987

Export Citation:

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Assignee:

TSUMURA JUNTENDO KK (JP)

International Classes:

A61K31/357; A61K31/36; C07D317/68; A61P1/16; (IPC1-7): C07D317/68; A61K31/36

Foreign References:

JPS60209582A

1985-10-22

Other References: