Title:
NOVEL BISPHOSPHONIC ACID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/131127
Kind Code:
A1
Abstract:
Provided are: a novel bisphosphonic acid compound which exhibits prominent inhibitory activity against ectopic calcification, or a salt thereof; and a pharmaceutical composition containing the compound or salt thereof. The bisphosphonic acid compound or pharmaceutically acceptable salt thereof is represented by general formula (1). [In the formula, the ------ part represents a single bond or a double bond, A represents a saturated cyclic hydrocarbon, or a saturated heterocycle that contains a sulfur atom or an oxygen atom, and R1 and R2 each independently represent an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an aryloxy group, a haloalkoxy group, a haloalkyl group, a halogen atom, or a hydrogen atom.]
Inventors:
KOBASHI SEIICHI (JP)
AOYAGI YOSHINOBU (JP)
KATO HIROSHIGE (JP)
TOKUYAMA RYUKO (JP)
ASHIZAWA NAOKI (JP)
ISHIDA KOICHI (JP)
MATSUMOTO KOJI (JP)
AOYAGI YOSHINOBU (JP)
KATO HIROSHIGE (JP)
TOKUYAMA RYUKO (JP)
ASHIZAWA NAOKI (JP)
ISHIDA KOICHI (JP)
MATSUMOTO KOJI (JP)
Application Number:
PCT/JP2017/002855
Publication Date:
August 03, 2017
Filing Date:
January 27, 2017
Export Citation:
Assignee:
FUJIYAKUHIN CO LTD (JP)
International Classes:
C07F9/38; A61K31/663; A61P9/00; A61P9/10; A61P19/08; A61P39/00
Foreign References:
| DD298267A5 | 1992-02-13 | |||
| JP2009530414A | 2009-08-27 | |||
| JPH07508278A | 1995-09-14 | |||
| JP2003519183A | 2003-06-17 |
Other References:
STEFANUCCI, AZZURRA ET AL.: "Investigation of the N-BP Binding at FPPS by Combined Computational Approaches", MEDICINAL CHEMISTRY, vol. 11, no. 5, 2015, pages 417 - 431, XP055508124
DRAKE, MATTHEW T. ET AL.: "Bisphosphonates: Mechanism of Action and Role in Clinical Practice", MAYO CLINIC PROCEEDINGS, vol. 83, no. 9, 2008, pages 1032 - 1045, XP055508125
DRAKE, MATTHEW T. ET AL.: "Bisphosphonates: Mechanism of Action and Role in Clinical Practice", MAYO CLINIC PROCEEDINGS, vol. 83, no. 9, 2008, pages 1032 - 1045, XP055508125
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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