Title:
NOVEL CAMPTOTHECIN DERIVATIVES AND CARRIER-DRUG CONJUGATE COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2024/054089
Kind Code:
A1
Abstract:
The present invention relates to novel camptothecin derivatives having the structures of chemical formulas 1 to 8 and carrier-drug conjugates including same, wherein the derivatives possess more desirable properties compared to existing camptothecin derivatives in terms of efficacy, toxicity, selectivity, duration of action, administration, handling, stability, and/or manufacturability and enjoy the advantage of maximizing the efficacy of the main drug target modulation through (i) simultaneous inhibition of the Bcl family such as the resistance protein Survivin, etc. and/or (ii) the additional mechanism of inhibiting efflux pump activity. The novel camptothecin derivatives and carrier-drug conjugates according to the present invention have excellent anticancer efficacy and safety and thus can be applied to the treatment of various cancers.
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Inventors:
JUNG DOO YOUNG (KR)
LEE JIN SOO (KR)
CHO HYUNG YONG (KR)
LEE BYEONG SUNG (KR)
SHIN SEUNG GUN (KR)
GANGADHAR RAO MATHI (KR)
JUNG JIN KYO (KR)
LEE JIN SOO (KR)
CHO HYUNG YONG (KR)
LEE BYEONG SUNG (KR)
SHIN SEUNG GUN (KR)
GANGADHAR RAO MATHI (KR)
JUNG JIN KYO (KR)
Application Number:
PCT/KR2023/013502
Publication Date:
March 14, 2024
Filing Date:
September 08, 2023
Export Citation:
Assignee:
PINOTBIO INC (KR)
International Classes:
C07D491/22; A61K31/4745; A61P35/00
Domestic Patent References:
| WO2021067861A1 | 2021-04-08 | |||
| WO2022170971A1 | 2022-08-18 |
Foreign References:
| KR20210006362A | 2021-01-18 | |||
| KR20220027828A | 2022-03-08 | |||
| US5342947A | 1994-08-30 |
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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