Title:
NOVEL CATIONIC AMPHIPHILIC LIPIDS FOR LIPOSOMAL GENE TRANSFER
Document Type and Number:
WIPO Patent Application WO1998005678
Kind Code:
A3
Abstract:
This invention relates to the synthesis of novel cationic, amphiphilic lipids and their application as gene transfer vehicles in vitro and in vivo. For this a series of different lipids (diglycerides, steroids) were synthesized by modification with variable cationic molecules (amino acids, biogenic amines). Compounds of this kind are, due to their capability of producing complexes with polynucleotides (DNA, RNA, Antisense oligonucleotides, ribozymes etc) suitable as vectors for gene transfer (transfection).
Inventors:
SCHNEIDER MANFRED (DE)
KEIL OLIVER (DE)
RESZKA REGINA (DE)
GROTH DETLEF (DE)
KEIL OLIVER (DE)
RESZKA REGINA (DE)
GROTH DETLEF (DE)
Application Number:
PCT/DE1997/001669
Publication Date:
February 25, 1999
Filing Date:
August 01, 1997
Export Citation:
Assignee:
MAX DELBRUECK CENTRUM (DE)
SCHNEIDER MANFRED (DE)
KEIL OLIVER (DE)
RESZKA REGINA (DE)
GROTH DETLEF (DE)
SCHNEIDER MANFRED (DE)
KEIL OLIVER (DE)
RESZKA REGINA (DE)
GROTH DETLEF (DE)
International Classes:
A61K9/127; A61K31/575; A61K48/00; C07C237/08; C07C237/12; C07C271/20; C07C279/14; C07J41/00; C12N15/88; C12N15/09; (IPC1-7): C07J41/00; A61K31/575; A61K9/127; C12N15/63; C07C271/20; C07C279/14; C07C237/08; A61K31/325; A61K31/16; A61K31/155
Domestic Patent References:
| WO1997000241A1 | 1997-01-03 | |||
| WO1986004579A1 | 1986-08-14 | |||
| WO1995004030A1 | 1995-02-09 | |||
| WO1996022303A1 | 1996-07-25 | |||
| WO1996018372A2 | 1996-06-20 | |||
| WO1994004545A1 | 1994-03-03 | |||
| WO1996014831A1 | 1996-05-23 |
Foreign References:
| FR2551758A1 | 1985-03-15 | |||
| EP0038750A1 | 1981-10-28 | |||
| US4584136A | 1986-04-22 |
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