Title:
NOVEL CATIONIC LIPID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/029578
Kind Code:
A1
Abstract:
The present application relates to a lipid compound, which can be used separately, or used in combination with other lipid components such as a neutral lipid, a charged lipid, a steroid and/or an analog thereof, and/or a polymer-conjugated lipid to form lipid nanoparticles for delivery of a therapeutic agent and/or a prophylactic agent. The lipid nanoparticles can be used for delivering nucleic acids, such as messenger RNA and/or antisense RNA. The lipid nanoparticles can be used for preparing a composition for treating and/or preventing a disease.
Inventors:
HUANG CAIGU (CN)
WANG SHUAI (CN)
HUANG TIEQIANG (CN)
WANG SHUAI (CN)
HUANG TIEQIANG (CN)
Application Number:
PCT/CN2022/092599
Publication Date:
March 09, 2023
Filing Date:
May 13, 2022
Export Citation:
Assignee:
GUANGZHOU ANOVENT PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D317/12; A61K9/127; C07D317/10
Other References:
PATEL SIDDHARTH; RYALS RENEE C.; WELLER KYLE K.; PENNESI MARK E.; SAHAY GAURAV: "Lipid nanoparticles for delivery of messenger RNA to the back of the eye", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 303, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 91 - 100, XP085712832, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.04.015
JUSTIN B. LEE, KAIXIN ZHANG, YUEN YI C. TAM, YING K. TAM, NATHAN M. BELLIVEAU, VANESSA Y.C. SUNG, PAULO J.C. LIN, ERIC LEBLANC, MA: "Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo", INTERNATIONAL JOURNAL OF CANCER, UNION INTERNATIONALE CENTRE LE CANCER., vol. 131, no. 5, 1 September 2012 (2012-09-01), pages E781 - E790, XP055083267, ISSN: 00207136, DOI: 10.1002/ijc.27361
THEWALT JENIFER, TIELEMAN D. PETER: "Biophysical experiments and simulation in nanoparticle-based drug delivery systems", JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS, GB, vol. 24, no. 9, 10 August 2016 (2016-08-10), GB , pages 768 - 773, XP009544113, ISSN: 1061-186X, DOI: 10.1080/1061186X.2016.1221957
JUSTIN B. LEE, KAIXIN ZHANG, YUEN YI C. TAM, YING K. TAM, NATHAN M. BELLIVEAU, VANESSA Y.C. SUNG, PAULO J.C. LIN, ERIC LEBLANC, MA: "Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo", INTERNATIONAL JOURNAL OF CANCER, UNION INTERNATIONALE CENTRE LE CANCER., vol. 131, no. 5, 1 September 2012 (2012-09-01), pages E781 - E790, XP055083267, ISSN: 00207136, DOI: 10.1002/ijc.27361
THEWALT JENIFER, TIELEMAN D. PETER: "Biophysical experiments and simulation in nanoparticle-based drug delivery systems", JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS, GB, vol. 24, no. 9, 10 August 2016 (2016-08-10), GB , pages 768 - 773, XP009544113, ISSN: 1061-186X, DOI: 10.1080/1061186X.2016.1221957
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