Title:
NOVEL CATIONIC LIPID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/029593
Kind Code:
A1
Abstract:
The present invention relates to a lipid compound, which can be used alone or in combination with other lipid components such as a neutral lipid, a charged lipid, a steroid and/or an analog thereof, and/or a polymer-conjugated lipid for forming a lipid nanoparticle for the delivery of a therapeutic and/or prophylactic agent. In some examples, the lipid nanoparticle is used to deliver a nucleic acid, such as a messenger RNA and/or antisense RNA. Further provided is a method for treating and/or preventing various diseases by means of using such a lipid nanoparticle. In one embodiment, provided is a compound having a structure as represented by following formula (I), or a salt, isomer or N-oxide thereof, wherein R is as defined herein, and further provided is a pharmaceutical composition comprising one or more of the above-mentioned compounds as represented by structural formula (I) and the therapeutic and/or prophylactic agent. In some embodiments, the pharmaceutical composition further comprises one or more components selected from a neutral lipid, a charged lipid, a steroid and a polymer-conjugated lipid. Such a composition is useful for forming a lipid nanoparticle for delivering the therapeutic and/or prophylactic agent. In the other embodiments, provided in the present invention is a method for administering the therapeutic and/or prophylactic agent to a subject in need thereof, and the method comprises preparing the pharmaceutical composition of lipid nanoparticles containing the compound as shown in the structural formula (I) and the therapeutic and/or prophylactic agent, and delivering the composition to the subject.
Inventors:
HUANG CAIGU (CN)
TAN JUNRONG (CN)
HUANG TIEQIANG (CN)
TAN JUNRONG (CN)
HUANG TIEQIANG (CN)
Application Number:
PCT/CN2022/093432
Publication Date:
March 09, 2023
Filing Date:
May 18, 2022
Export Citation:
Assignee:
GUANGZHOU ANOVENT PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C229/12; A61K9/51; A61K47/18; A61K48/00
Domestic Patent References:
| WO2017201346A1 | 2017-11-23 |
Foreign References:
| CN110520409A | 2019-11-29 | |||
| US20190275170A1 | 2019-09-12 | |||
| US20190300906A1 | 2019-10-03 | |||
| US20200268666A1 | 2020-08-27 | |||
| CN108368028A | 2018-08-03 |
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