Title:
NOVEL CHLORIN E6-CURCUMIN DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2018/236193
Kind Code:
A1
Abstract:
The present invention relates to novel chlorine e6-curcumin derivatives, a preparation method thereof for the treatment of cancer, and in particularly, novel compounds were prepared by using different linkers such as hydrophobic and hydrophilic linkers to conjugate chlorine e6 to curcumin, the compounds under investigation showed excellent photophysical properties, stability, and anticancer activity.
Inventors:
JALDE SHIVAKUMAR S (KR)
KIM YONG WAN (KR)
SON KWANG HEE (KR)
LEE HWAN SUK (KR)
KIM YONG WAN (KR)
SON KWANG HEE (KR)
LEE HWAN SUK (KR)
Application Number:
PCT/KR2018/007124
Publication Date:
December 27, 2018
Filing Date:
June 22, 2018
Export Citation:
Assignee:
DONG SUNG PHARM CO LTD (KR)
International Classes:
A61K31/12; C07D487/22; A61K31/409
Domestic Patent References:
| WO2013051778A1 | 2013-04-11 |
Foreign References:
| CN103224499A | 2013-07-31 |
Other References:
HUANG, Q. ET AL.: "Synthesis and characterization of curcumin bridged porphyrins as photosensitizers", CHEMICAL JOURNAL OF CHINESE UNIVERSITIES, vol. 33, no. 4, 2012, pages 732 - 737
BELYKH, D. V. ET AL.: "Synthesis of potential antitumor agents, dimeric and trimeric chlorins, from methylpheophorbide a", RUSSIAN CHEMICAL BULLETIN , INTERNATIONAL EDITION, vol. 60, no. 4, April 2011 (2011-04-01), pages 719 - 728, XP055565999
ZHENG, G. ET AL.: "Chlorin-based symmetrical and unsymmetrical dimers with amide linkages: effect of the substituents on photodynamic and photophysical properties", J. CHEM. SOC., PERKIN TRANS., vol. 1, January 2000 (2000-01-01), pages 3113 - 3121, XP002269059
GRIN, M. A. ET AL.: "New conjugates of cobalt bis(dicarbollide) with chlorophyll a derivatives", MENDELEEV COMMUNICATIONS, vol. 21, 9 April 2011 (2011-04-09), pages 84 - 86, XP028189740
PRÖHL, M. ET AL.: "Metal complexes of curcumin and curcumin derivatives for molecular imaging and anticancer therapy", COORDINATION CHEMISTRY REVIEWS, vol. 307, 9 September 2015 (2015-09-09), pages 32 - 41, XP029317161
JALDE, S. S. ET AL.: "Synthesis of novel Chlorin e6-curcumin conjugates as photosensitizers for photodynamic therapy against pancreatic carcinoma", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 147, 2 February 2018 (2018-02-02), pages 66 - 76, XP055566014
BELYKH, D. V. ET AL.: "Synthesis of potential antitumor agents, dimeric and trimeric chlorins, from methylpheophorbide a", RUSSIAN CHEMICAL BULLETIN , INTERNATIONAL EDITION, vol. 60, no. 4, April 2011 (2011-04-01), pages 719 - 728, XP055565999
ZHENG, G. ET AL.: "Chlorin-based symmetrical and unsymmetrical dimers with amide linkages: effect of the substituents on photodynamic and photophysical properties", J. CHEM. SOC., PERKIN TRANS., vol. 1, January 2000 (2000-01-01), pages 3113 - 3121, XP002269059
GRIN, M. A. ET AL.: "New conjugates of cobalt bis(dicarbollide) with chlorophyll a derivatives", MENDELEEV COMMUNICATIONS, vol. 21, 9 April 2011 (2011-04-09), pages 84 - 86, XP028189740
PRÖHL, M. ET AL.: "Metal complexes of curcumin and curcumin derivatives for molecular imaging and anticancer therapy", COORDINATION CHEMISTRY REVIEWS, vol. 307, 9 September 2015 (2015-09-09), pages 32 - 41, XP029317161
JALDE, S. S. ET AL.: "Synthesis of novel Chlorin e6-curcumin conjugates as photosensitizers for photodynamic therapy against pancreatic carcinoma", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 147, 2 February 2018 (2018-02-02), pages 66 - 76, XP055566014
Attorney, Agent or Firm:
KIM, Dong Jin (KR)
Download PDF: