NOVEL COMPOUND AS REARRANGED DURING TRANSFECTION KINASE INHIBITOR

Title:

NOVEL COMPOUND AS REARRANGED DURING TRANSFECTION KINASE INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2021/197250

Kind Code:

A1

Abstract:

The present invention relates to a compound, a pharmaceutical composition comprising same, a preparation method therefor, and use of same as a rearranged during transfection (RET) kinase inhibitor. The compound is a compound shown as formula (I), or a pharmaceutically acceptable salt, a prodrug, an isomer and a stable isotope derivative thereof. The present invention also relates to use of the compound for the treatment or prevention of related-diseases mediated by RET kinase such as tumors, and a method for using same in the treatment of the diseases.

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Inventors:

KONG NORMAN XIANGLONG (CN)
ZHOU CHAO (CN)
ZHENG ZHIXIANG (CN)

Application Number:

PCT/CN2021/083528

Publication Date:

October 07, 2021

Filing Date:

March 29, 2021

Export Citation:

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Assignee:

NANJING INNOCARE PHARMA TECH CO LTD (CN)

International Classes:

C07D401/14; A61K31/4709; A61K31/496; A61K31/497; A61K31/517; A61P35/00; A61P35/02; C07D403/14; C07D405/14; C07D471/08; C07D487/10

Domestic Patent References:

WO2012171337A1

2012-12-20

Foreign References:

CN111777593A	2020-10-16
JP6378918B2	2018-08-22

Attorney, Agent or Firm:

CHINA PATENT AGENT (H.K.) LTD. (CN)

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