Title:
NOVEL COMPOUND, AND COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING BACTERIAL INFLAMMATION AND INFLAMMASOME-MEDIATED DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/158290
Kind Code:
A1
Abstract:
The present application relates to: a compound of chemical formula 1, an isomer thereof or a pharmaceutically acceptable salt thereof; and use thereof for preventing, alleviating and/or treating inflammasome-mediated diseases and/or gram-negative bacteria infections or diseases caused by gram-negative bacteria, does not exhibit cell cytotoxicity, and thus is safe, and can effectively inhibit inflammasomes, thereby having the excellent effects of preventing, alleviating and/or treating these diseases.
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Inventors:
SIM JAE HYUN (KR)
LI LINZI (KR)
RYU EUNJU (KR)
KIM YUNJI (KR)
KIM HYE EUN (KR)
YIM SANGEUN (KR)
LI LINZI (KR)
RYU EUNJU (KR)
KIM YUNJI (KR)
KIM HYE EUN (KR)
YIM SANGEUN (KR)
Application Number:
PCT/KR2023/002477
Publication Date:
August 24, 2023
Filing Date:
February 21, 2023
Export Citation:
Assignee:
QUORUM BIO CO LTD (KR)
International Classes:
A61K31/4035; A23K20/132; A23K20/195; A23L33/10; A61K45/06; A61P25/28; A61P31/04
Foreign References:
| KR20190130983A | 2019-11-25 | |||
| KR20170141133A | 2017-12-22 |
Other References:
KLAUS-DIETER WARZECHA, JÖRG M. NEUDÖRFL, AXEL G. GRIESBECK: "(Z)-3-(4-Methoxybenzylidene)-2-methylisoindolin-1-one", ACTA CRYSTALLOGRAPHICA SECTION E, JOHN WILEY & SONS, GB, vol. E61, no. 4, 1 January 2005 (2005-01-01), GB , pages o1074 - o1075, XP009548595, ISSN: 1600-5368, DOI: 10.1107/S1600536805008238
OLSEN INGAR: "Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s Disease", FRONTIERS IN NEUROSCIENCE, vol. 15, 14 October 2020 (2020-10-14), pages 691016, XP093086317, DOI: 10.3389/fnins.2021.691016
MASATO YONEDA;SHUHEI NAKA;KAZUHIKO NAKANO;KOICHIRO WADA;HIROKI ENDO;HIRONORI MAWATARI;KENTO IMAJO;RYOTA NOMURA;KAZUYA HOKAMURA;MAS: "Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease", BMC GASTROENTEROLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 12, no. 1, 16 February 2012 (2012-02-16), GB , pages 16, XP021117992, ISSN: 1471-230X, DOI: 10.1186/1471-230X-12-16
KRISHNAMURTI VINAYAK, MUNOZ SOCRATES B., ISPIZUA-RODRIGUEZ XANATH, VICKERMAN JEFFREY, MATHEW THOMAS, SURYA PRAKASH G. K.: "C(sp 2 )–H Trifluoromethylation of enamides using TMSCF 3 : access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 54, no. 75, 1 January 2018 (2018-01-01), UK , pages 10574 - 10577, XP093086321, ISSN: 1359-7345, DOI: 10.1039/C8CC04907F
FRECCERO, M. ET AL.: "Photochemical reaction of phthalimides and dicyanophthalimides with benzylic donors", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 58, no. 7, 1 January 1993 (1993-01-01), pages 1740 - 1745, XP002153438, ISSN: 0022-3263, DOI: 10.1021/jo00059a023
XIAORONG ZHOU, ZHIXING PENG, HONGYANG ZHAO, ZHIYIN ZHANG, PING LU, YANGUANG WANG: "Rh-Catalyzed annulations of N-methoxybenzamides with ketenimines: synthesis of 3-aminoisoindolinones and 3-diarylmethyleneisoindolinones with strong aggregation induced emission properties", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 52, no. 70, 1 January 2016 (2016-01-01), UK , pages 10676 - 10679, XP055753301, ISSN: 1359-7345, DOI: 10.1039/C6CC05456K
OLSEN INGAR: "Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s Disease", FRONTIERS IN NEUROSCIENCE, vol. 15, 14 October 2020 (2020-10-14), pages 691016, XP093086317, DOI: 10.3389/fnins.2021.691016
MASATO YONEDA;SHUHEI NAKA;KAZUHIKO NAKANO;KOICHIRO WADA;HIROKI ENDO;HIRONORI MAWATARI;KENTO IMAJO;RYOTA NOMURA;KAZUYA HOKAMURA;MAS: "Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease", BMC GASTROENTEROLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 12, no. 1, 16 February 2012 (2012-02-16), GB , pages 16, XP021117992, ISSN: 1471-230X, DOI: 10.1186/1471-230X-12-16
KRISHNAMURTI VINAYAK, MUNOZ SOCRATES B., ISPIZUA-RODRIGUEZ XANATH, VICKERMAN JEFFREY, MATHEW THOMAS, SURYA PRAKASH G. K.: "C(sp 2 )–H Trifluoromethylation of enamides using TMSCF 3 : access to trifluoromethylated isoindolinones, isoquinolinones, 2-pyridinones and other heterocycles", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 54, no. 75, 1 January 2018 (2018-01-01), UK , pages 10574 - 10577, XP093086321, ISSN: 1359-7345, DOI: 10.1039/C8CC04907F
FRECCERO, M. ET AL.: "Photochemical reaction of phthalimides and dicyanophthalimides with benzylic donors", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 58, no. 7, 1 January 1993 (1993-01-01), pages 1740 - 1745, XP002153438, ISSN: 0022-3263, DOI: 10.1021/jo00059a023
XIAORONG ZHOU, ZHIXING PENG, HONGYANG ZHAO, ZHIYIN ZHANG, PING LU, YANGUANG WANG: "Rh-Catalyzed annulations of N-methoxybenzamides with ketenimines: synthesis of 3-aminoisoindolinones and 3-diarylmethyleneisoindolinones with strong aggregation induced emission properties", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 52, no. 70, 1 January 2016 (2016-01-01), UK , pages 10676 - 10679, XP055753301, ISSN: 1359-7345, DOI: 10.1039/C6CC05456K
Attorney, Agent or Firm:
YOU ME PATENT AND LAW FIRM (KR)
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