NOVEL COMPOUND HAVING 1,4-BENZOXAZIN-3-ONE SKELETON

WIPO Patent Application WO/2008/053861

A1

The object is to synthesize and study a novel compound having a 1,4-benzoxazin-3-one skeleton and find a pharmacological activity of the compound. Specifically provided is a compound represented by the formula [I] or a salt thereof [wherein the ring A represents a benzene ring, a thiophene ring, a thiazole ring, a furan ring or the like; R1 and R2 independently represent a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aromatic heterocyclic group or the like; X represents a single bond, C=C, CH2-O, O-CH2, NH-CH2, CH2-NH or the like; Y represents a hydroxyl group, an alkyl group, an alkoxy group, NR3R4 or the like; and R3 and R4 independently represent a hydrogen atom, a hydroxy group, an alkyl group, an alkoxy group, a cycloalkyl group, an aryl group, an aromatic heterocyclic group, a non-aromatic heterocyclic group, or the like.

HONDA TAKAHIRO (JP)
FUJISAWA KOUSHI (JP)
AONO HIROYUKI (JP)
BAN MASAKAZU (JP)

PCT/JP2007/071069

May 08, 2008

October 30, 2007

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SANTEN PHARMACEUTICAL CO LTD (JP)
HONDA TAKAHIRO (JP)
FUJISAWA KOUSHI (JP)
AONO HIROYUKI (JP)
BAN MASAKAZU (JP)

C07D265/36; A61K31/4375; A61K31/444; A61K31/496; A61K31/538; A61P9/00; A61P9/10; A61P17/06; A61P19/02; A61P29/00; A61P35/00; C07D413/06; C07D413/12; C07D413/14; C07D417/06; C07D471/04

WO2004014389A1

2004-02-19

JP2003501429A	2003-01-14
JP2004528335A	2004-09-16
JPH08501318A	1996-02-13
US5852210A	1998-12-22

GEZGINCI H. ET AL.: "Synthesis of new 2-arylidene-2H-1,4-benzoxazin-3(4H)-ones", IL FARMACO, vol. 52, no. 4, 1997, pages 255 - 256

HIBI, Norihiko et al. (3rd Floor Inaba Building, 13-18, Nishishinsaibashi 1-chome, Chuo-ku, Osaka-sh, Osaka 86, JP)

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