Title:
NOVEL COMPOUND HAVING 1,4-BENZOXAZIN-3-ONE SKELETON
Document Type and Number:
WIPO Patent Application WO/2008/053861
Kind Code:
A1
Abstract:
The object is to synthesize and study a novel compound having a 1,4-benzoxazin-3-one skeleton and find a pharmacological activity of the compound. Specifically provided is a compound represented by the formula [I] or a salt thereof [wherein the ring A represents a benzene ring, a thiophene ring, a thiazole ring, a furan ring or the like; R1 and R2 independently represent a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aromatic heterocyclic group or the like; X represents a single bond, C=C, CH2-O, O-CH2, NH-CH2, CH2-NH or the like; Y represents a hydroxyl group, an alkyl group, an alkoxy group, NR3R4 or the like; and R3 and R4 independently represent a hydrogen atom, a hydroxy group, an alkyl group, an alkoxy group, a cycloalkyl group, an aryl group, an aromatic heterocyclic group, a non-aromatic heterocyclic group, or the like.
Inventors:
HONDA TAKAHIRO (JP)
FUJISAWA KOUSHI (JP)
AONO HIROYUKI (JP)
BAN MASAKAZU (JP)
FUJISAWA KOUSHI (JP)
AONO HIROYUKI (JP)
BAN MASAKAZU (JP)
Application Number:
PCT/JP2007/071069
Publication Date:
May 08, 2008
Filing Date:
October 30, 2007
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
HONDA TAKAHIRO (JP)
FUJISAWA KOUSHI (JP)
AONO HIROYUKI (JP)
BAN MASAKAZU (JP)
HONDA TAKAHIRO (JP)
FUJISAWA KOUSHI (JP)
AONO HIROYUKI (JP)
BAN MASAKAZU (JP)
International Classes:
C07D265/36; A61K31/4375; A61K31/444; A61K31/496; A61K31/538; A61P9/00; A61P9/10; A61P17/06; A61P19/02; A61P29/00; A61P35/00; C07D413/06; C07D413/12; C07D413/14; C07D417/06; C07D471/04
Domestic Patent References:
WO2004014389A1 | 2004-02-19 |
Foreign References:
JP2003501429A | 2003-01-14 | |||
JP2004528335A | 2004-09-16 | |||
JPH08501318A | 1996-02-13 | |||
US5852210A | 1998-12-22 |
Other References:
GEZGINCI H. ET AL.: "Synthesis of new 2-arylidene-2H-1,4-benzoxazin-3(4H)-ones", IL FARMACO, vol. 52, no. 4, 1997, pages 255 - 256
Attorney, Agent or Firm:
HIBI, Norihiko et al. (3rd Floor Inaba Building, 13-18, Nishishinsaibashi 1-chome, Chuo-ku, Osaka-sh, Osaka 86, JP)
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