NOVEL COMPOUND HAVING 3-HETEROARYLPYRIMIDIN-4-(3H)-ONE STRUCTURE AND PHARMACEUTICAL PREPARATION CONTAINING SAME

Title:

NOVEL COMPOUND HAVING 3-HETEROARYLPYRIMIDIN-4-(3H)-ONE STRUCTURE AND PHARMACEUTICAL PREPARATION CONTAINING SAME

Document Type and Number:

WIPO Patent Application WO/2010/119700

Kind Code:

A1

Abstract:

Disclosed is a compound which has both an angiotensin-II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, renal diseases, arteriosclerosis, inflammatory diseases, type-2 diabetes, diabetic complications, insulin resistance syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. [In the formula, A represents a 5- to 10-membered heteroaryl group; R1 and R2 independently represent a C1-6 alkyl group; and each of R3 to R5 is absent or represents H, a halogen atom, OH, NO2, a halo-C1-6 alkyl group, a (substituted) C1-6 alkoxy group, a (substituted) C3-6 cycloalkyloxy group, or a 5- to 10-membered heteroaryl group.]

More Like This:

JPH0699306	[Title of the Invention] 3-allyloxyazetidinecarboxamide as an anticonvulsant and an antiepileptic agent
JP2022501400	Method for producing steric hindrance nitrogen-containing heteroaromatic compound
WO/2021/263203	CXCR4 INHIBITORS AND USES THEREOF

Inventors:

MIURA TORU (JP)
ONOGI KAZUHIRO (JP)
SATO SEIICHI (JP)
TAGASHIRA JUNYA (JP)
WATANABE GEN (JP)
SEKIMOTO RYOHEI (JP)
ISHIDA RIE (JP)
AOKI HITOMI (JP)
OHGIYA TADAAKI (JP)

Application Number:

PCT/JP2010/002766

Publication Date:

October 21, 2010

Filing Date:

April 16, 2010

Export Citation:

Click for automatic bibliography generation Help

Assignee:

KOWA CO (JP)
MIURA TORU (JP)
ONOGI KAZUHIRO (JP)
SATO SEIICHI (JP)
TAGASHIRA JUNYA (JP)
WATANABE GEN (JP)
SEKIMOTO RYOHEI (JP)
ISHIDA RIE (JP)
AOKI HITOMI (JP)
OHGIYA TADAAKI (JP)

International Classes:

C07D401/14; A61K31/506; A61K31/53; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; A61P43/00; C07D403/14; C07D413/14; C07D417/14

Domestic Patent References:

WO2008062905A2	2008-05-29
WO2008084303A1	2008-07-17
WO2008096820A1	2008-08-14
WO2008096829A1	2008-08-14

Foreign References:

JPH04230370A	1992-08-19
JPH05505609A	1993-08-19
JPH06199811A	1994-07-19
JPH06509349A	1994-10-20
JPH06509349A	1994-10-20
JPH04230370A	1992-08-19

Other References:

NICOLAIE, E. ET AL.: "Synthesis and angiotensin II receptor antagonist activity of C-linked pyrimidine derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 5, 1995, pages 365 - 75, XP000602152
AMER. J. HYPERTENSION, vol. 18, 2005, pages 720
CURRENT HYPERTENSION REPORT, vol. 10, 2008, pages 261
DIABETES CARE, vol. 30, 2007, pages 1581
KIDNEY INT., vol. 70, 2006, pages 1223
CIRCULATION, vol. 108, 2003, pages 2941
BEST PRACT. RES. CLIN. ENDOCRINOL. METAB., vol. 21, no. 4, 2007, pages 687
DIAB. VASC. DIS. RES., vol. 1, no. 2, 2004, pages 76
DIAB. VASC. DIS. RES., vol. 2, no. 2, 2005, pages 61
J. CLIN. INVEST., vol. 116, no. 3, 2006, pages 581
FASEB J., vol. 20, no. 8, 2006, pages 1203
HYPERTENSION, vol. 43, 2004, pages 993
CIRCULATION, vol. 109, 2004, pages 2054
PROGRESS IN MEDICINE, vol. 5, 1985, pages 2157 - 2161
"Molecular Designs", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Drugs", pages: 163 - 198
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC
JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 24, 1995, pages 4806
SYNTHESIS, 2004, pages 2825
See also references of EP 2420501A4

Attorney, Agent or Firm:

SAEKI, NORIO (JP)
Norio Saeki (JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: PROCESSOR FOR THREE DIMENSIONAL COMPUTER GRAPHICS

Next Patent: LIGHT-EMITTING DEVICE