Title:
NOVEL COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION
Document Type and Number:
WIPO Patent Application WO/1999/005091
Kind Code:
A1
Abstract:
A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.
Inventors:
SAITO SEIICHI (JP)
NAGAI MASASHI (JP)
MORINO TOMIO (JP)
TOMIYOSHI TSUGIO (JP)
NISHIKIORI TAKAAKI (JP)
KUWAHARA ATSUSHI (JP)
SATO TAKAMICHI (JP)
HARADA TAKASHI (JP)
NAGAI MASASHI (JP)
MORINO TOMIO (JP)
TOMIYOSHI TSUGIO (JP)
NISHIKIORI TAKAAKI (JP)
KUWAHARA ATSUSHI (JP)
SATO TAKAMICHI (JP)
HARADA TAKASHI (JP)
Application Number:
PCT/JP1998/003313
Publication Date:
February 04, 1999
Filing Date:
July 24, 1998
Export Citation:
Assignee:
NIPPON KAYAKU KK (JP)
SAITO SEIICHI (JP)
NAGAI MASASHI (JP)
MORINO TOMIO (JP)
TOMIYOSHI TSUGIO (JP)
NISHIKIORI TAKAAKI (JP)
KUWAHARA ATSUSHI (JP)
SATO TAKAMICHI (JP)
HARADA TAKASHI (JP)
SAITO SEIICHI (JP)
NAGAI MASASHI (JP)
MORINO TOMIO (JP)
TOMIYOSHI TSUGIO (JP)
NISHIKIORI TAKAAKI (JP)
KUWAHARA ATSUSHI (JP)
SATO TAKAMICHI (JP)
HARADA TAKASHI (JP)
International Classes:
A61K31/16; A61K31/40; A61K31/44; A61K31/445; C07C229/04; C07C229/34; C07C323/25; C07C323/41; C07C323/53; C07C323/58; C07C323/60; C07D205/04; C07D207/16; C07D213/32; C07D213/50; C07D213/55; C07D295/145; C07D295/155; C07D295/18; C07D295/185; C07D295/192; C07D307/54; (IPC1-7): C07C229/04; C07D207/16; C07D205/04; C07D213/32; C07D307/54; C07D213/55; C07D295/18; A61K31/40; A61K31/44; A61K31/445; A61K31/395; A61K31/495; A61K31/34
Foreign References:
| JPS5777669A | 1982-05-15 | |||
| US3755118A | 1973-08-28 | |||
| JPH05238978A | 1993-09-17 | |||
| JPS62149666A | 1987-07-03 |
Other References:
KULIEV A M, ET AL.: "SYNTHESIS OF AMINOMETHYLTHIOMETHYL DELIVATIVES OF CYCLOPENTANONE AND CYCLOHAXANONE AND CONVERSION OF THE RESULTING SUBSTANCES", ZHURNAL ORGANICHESKOI KHIMII, MAIK NAUKA, MOSCOW, RU, vol. 13, no. 10, 1 January 1977 (1977-01-01), MOSCOW, RU, pages 1993 - 1995, XP002912915, ISSN: 0514-7492
TAKAMATSU Y., ET AL.: "INHIBITION OF HUMAN HEPATIC GLUTATHIONE S-TRANSFERASE ISOZYMES BY ETHACRYNIC ACID AND ITS METABOLITES.", TOXICOLOGY LETTERS., ELSEVIER BIOMEDICAL PRESS, AMSTERDAM,, NL, vol. 62., no. 02/03., 1 January 1992 (1992-01-01), NL, pages 241 - 245., XP002912914, ISSN: 0378-4274, DOI: 10.1016/0378-4274(92)90027-H
TAKAMATSU Y., ET AL.: "INHIBITION OF HUMAN HEPATIC GLUTATHIONE S-TRANSFERASE ISOZYMES BY ETHACRYNIC ACID AND ITS METABOLITES.", TOXICOLOGY LETTERS., ELSEVIER BIOMEDICAL PRESS, AMSTERDAM,, NL, vol. 62., no. 02/03., 1 January 1992 (1992-01-01), NL, pages 241 - 245., XP002912914, ISSN: 0378-4274, DOI: 10.1016/0378-4274(92)90027-H
Attorney, Agent or Firm:
Asamura, Kiyoshi (New Ohtemachi Building 2-1, Ohtemachi 2-chome Chiyoda-ku Tokyo, JP)
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