NOVEL COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME FOR TREATING OR PREVENTING NERVE DAMAGE, NEUROLOGICAL DISEASE, OR DEVELOPMENTAL DISORDER THROUGH PROLIFERATION PROMOTION, DIFFERENTIATION, AND/OR REGENERATION OF NERVE CELLS

WIPO Patent Application WO/2023/106883

A1

The present invention discloses a novel compound, a method for producing same, and a pharmaceutical composition containing same. The compound according to the present invention is represented by chemical formula 1. In chemical formula 1, M is selected from among Gd3+, Mg2+, and Ca2+, A represents *-(CH2)n-NH-* (n is an integer of 0-5), and B represents a moiety derived from retinoic acid.

CHANG SHA JOUNG (KR)
KIM YEOUN HEE (KR)
CHOI GA RAM (KR)
PARK HYUN JIN (KR)
KIM YE SL (KR)

PCT/KR2022/020026

June 15, 2023

December 09, 2022

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ETNOVA THERAPEUTICS CORP (KR)

C07F5/00; A61K31/395; A61K31/555; A61P25/00; C07F3/02; C07F3/04

US20100322855A1	2010-12-23
KR20180043360A	2018-04-27
JP2012504131A	2012-02-16
KR20180081558A	2018-07-16

CRICH, S. G. ET AL.: "In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, 2006, pages 4926 - 4936, XP008153001, DOI: 10.1021/jm0601093
LEE, H. -P. ET AL.: "All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease", EXPERT REVIEW OF NEUROTHERAPEUTICS, vol. 9, no. 11, 2009, pages 1615 - 1621, XP009532746, DOI: 10.1586/ern.09.86

NAM, Gun Pil et al. (KR)

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