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Title:
NOVEL COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME FOR TREATING OR PREVENTING NERVE DAMAGE, NEUROLOGICAL DISEASE, OR DEVELOPMENTAL DISORDER THROUGH PROLIFERATION PROMOTION, DIFFERENTIATION, AND/OR REGENERATION OF NERVE CELLS
Document Type and Number:
WIPO Patent Application WO/2023/106883
Kind Code:
A1
Abstract:
The present invention discloses a novel compound, a method for producing same, and a pharmaceutical composition containing same. The compound according to the present invention is represented by chemical formula 1. In chemical formula 1, M is selected from among Gd3+, Mg2+, and Ca2+, A represents *-(CH2)n-NH-* (n is an integer of 0-5), and B represents a moiety derived from retinoic acid.

Inventors:
CHANG SHA JOUNG (KR)
KIM YEOUN HEE (KR)
CHOI GA RAM (KR)
PARK HYUN JIN (KR)
KIM YE SL (KR)
Application Number:
PCT/KR2022/020026
Publication Date:
June 15, 2023
Filing Date:
December 09, 2022
Export Citation:
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Assignee:
ETNOVA THERAPEUTICS CORP (KR)
International Classes:
C07F5/00; A61K31/395; A61K31/555; A61P25/00; C07F3/02; C07F3/04
Foreign References:
US20100322855A12010-12-23
KR20180043360A2018-04-27
JP2012504131A2012-02-16
KR20180081558A2018-07-16
Other References:
CRICH, S. G. ET AL.: "In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, 2006, pages 4926 - 4936, XP008153001, DOI: 10.1021/jm0601093
LEE, H. -P. ET AL.: "All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease", EXPERT REVIEW OF NEUROTHERAPEUTICS, vol. 9, no. 11, 2009, pages 1615 - 1621, XP009532746, DOI: 10.1586/ern.09.86
Attorney, Agent or Firm:
NAM, Gun Pil et al. (KR)
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