Title:
NOVEL COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME FOR TREATING OR PREVENTING NERVE DAMAGE, NEUROLOGICAL DISEASE, OR DEVELOPMENTAL DISORDER THROUGH PROLIFERATION PROMOTION, DIFFERENTIATION, AND/OR REGENERATION OF NERVE CELLS
Document Type and Number:
WIPO Patent Application WO/2023/106883
Kind Code:
A1
Abstract:
The present invention discloses a novel compound, a method for producing same, and a pharmaceutical composition containing same. The compound according to the present invention is represented by chemical formula 1. In chemical formula 1, M is selected from among Gd3+, Mg2+, and Ca2+, A represents *-(CH2)n-NH-* (n is an integer of 0-5), and B represents a moiety derived from retinoic acid.
Inventors:
CHANG SHA JOUNG (KR)
KIM YEOUN HEE (KR)
CHOI GA RAM (KR)
PARK HYUN JIN (KR)
KIM YE SL (KR)
KIM YEOUN HEE (KR)
CHOI GA RAM (KR)
PARK HYUN JIN (KR)
KIM YE SL (KR)
Application Number:
PCT/KR2022/020026
Publication Date:
June 15, 2023
Filing Date:
December 09, 2022
Export Citation:
Assignee:
ETNOVA THERAPEUTICS CORP (KR)
International Classes:
C07F5/00; A61K31/395; A61K31/555; A61P25/00; C07F3/02; C07F3/04
Foreign References:
US20100322855A1 | 2010-12-23 | |||
KR20180043360A | 2018-04-27 | |||
JP2012504131A | 2012-02-16 | |||
KR20180081558A | 2018-07-16 |
Other References:
CRICH, S. G. ET AL.: "In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, 2006, pages 4926 - 4936, XP008153001, DOI: 10.1021/jm0601093
LEE, H. -P. ET AL.: "All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease", EXPERT REVIEW OF NEUROTHERAPEUTICS, vol. 9, no. 11, 2009, pages 1615 - 1621, XP009532746, DOI: 10.1586/ern.09.86
LEE, H. -P. ET AL.: "All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease", EXPERT REVIEW OF NEUROTHERAPEUTICS, vol. 9, no. 11, 2009, pages 1615 - 1621, XP009532746, DOI: 10.1586/ern.09.86
Attorney, Agent or Firm:
NAM, Gun Pil et al. (KR)
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