Title:
NOVEL COMPOUND THAT INHIBITS TNF-A GENERATION AND INFLAMMASOME ACTIVITY AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/008891
Kind Code:
A1
Abstract:
The present invention relates to a novel compound and a preparation method therefor. The compound according to the present invention exhibits inhibitory activity against the generation of TNF-α that is an inflammatory cytokine produced by inflammation initiation reaction, and against the generation of IL-1β by inflammasome activation, and thus, can be developed as a therapeutic agent for related inflammatory diseases.
Inventors:
SEONG SEUNG YONG (KR)
LEE EUN HO (KR)
LEE EUN HO (KR)
Application Number:
PCT/KR2022/010998
Publication Date:
February 02, 2023
Filing Date:
July 26, 2022
Export Citation:
Assignee:
SHAPERON INC (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07J31/00; A61K31/575; A61K31/58; A61P29/00; C07J43/00
Domestic Patent References:
| WO2020076815A1 | 2020-04-16 | |||
| WO2007111994A2 | 2007-10-04 |
Foreign References:
| KR101778687B1 | 2017-09-27 | |||
| KR940021065A | 1994-10-17 |
Other References:
CHOI HYUNG JUN, YUN JUN-WON, KIM YOUN-HEE, KWON EUNA, HYON MIN-KYONG, KIM JI YOUNG, CHE JEONG-HWAN, HO KIM WOO, SEONG SEUNG-YONG, : "Evaluation of acute and subacute toxicity of sodium taurodeoxycholate in rats", DRUG AND CHEMICAL TOXICOLOGY., MARCEL DEKKER INC., US, vol. 44, no. 3, 4 May 2021 (2021-05-04), US , pages 268 - 276, XP009542917, ISSN: 0148-0545, DOI: 10.1080/01480545.2019.1609493
ROBERTO PELLICCIARI, ANTIMO GIOIELLO, ANTONIO MACCHIARULO, CHARLES THOMAS, EMILIANO ROSATELLI, BENEDETTO NATALINI, ROCCALDO SARDEL: "Discovery of 6α-Ethyl-23( S )-methylcholic Acid ( S -EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 52, no. 24, 24 December 2009 (2009-12-24), pages 7958 - 7961, XP055099941, ISSN: 00222623, DOI: 10.1021/jm901390p
MARTIN ELODIE; AMAR MAJID; DALLE CARINE; YOUSSEF IHSEN; BOUCHER CéLINE; DUIGOU CAROLINE LE; BRüCKNER MATTHIAS; PRIGENT A: "New role of P2X7 receptor in an Alzheimer’s disease mouse model", MOLECULAR PSYCHIATRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 24, no. 1, 22 June 2018 (2018-06-22), London, pages 108 - 125, XP036668664, ISSN: 1359-4184, DOI: 10.1038/s41380-018-0108-3
ROBERTO PELLICCIARI, ANTIMO GIOIELLO, ANTONIO MACCHIARULO, CHARLES THOMAS, EMILIANO ROSATELLI, BENEDETTO NATALINI, ROCCALDO SARDEL: "Discovery of 6α-Ethyl-23( S )-methylcholic Acid ( S -EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 52, no. 24, 24 December 2009 (2009-12-24), pages 7958 - 7961, XP055099941, ISSN: 00222623, DOI: 10.1021/jm901390p
MARTIN ELODIE; AMAR MAJID; DALLE CARINE; YOUSSEF IHSEN; BOUCHER CéLINE; DUIGOU CAROLINE LE; BRüCKNER MATTHIAS; PRIGENT A: "New role of P2X7 receptor in an Alzheimer’s disease mouse model", MOLECULAR PSYCHIATRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 24, no. 1, 22 June 2018 (2018-06-22), London, pages 108 - 125, XP036668664, ISSN: 1359-4184, DOI: 10.1038/s41380-018-0108-3
Attorney, Agent or Firm:
KIM, Bo Jung (KR)
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