Title:
NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2017/006931
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake.
(In the formula, each of A and Z independently represents CO, SO or SO2; each of X and Y independently represents S or O; each of R1-R4 independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each R5 independently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.)
Inventors:
TAKAHASHI TAKUYA (JP)
MIYAZAKI TOMOYUKI (JP)
SUHARA TETSUYA (JP)
HIGUCHI MAKOTO (JP)
CHO MEIEI (JP)
MIYAZAKI TOMOYUKI (JP)
SUHARA TETSUYA (JP)
HIGUCHI MAKOTO (JP)
CHO MEIEI (JP)
Application Number:
PCT/JP2016/069896
Publication Date:
January 12, 2017
Filing Date:
July 05, 2016
Export Citation:
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
NAT INST FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
NAT INST FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
International Classes:
C07C323/49; A61K51/00; C07C319/20; C07F7/22; C07B59/00
Domestic Patent References:
| WO1996025926A1 | 1996-08-29 | |||
| WO2014163210A1 | 2014-10-09 | |||
| WO2011002096A1 | 2011-01-06 | |||
| WO2015066456A1 | 2015-05-07 |
Foreign References:
| JPH04364158A | 1992-12-16 |
Other References:
AHMED, A. H. ET AL.: "Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA", BIOCHEMISTRY, vol. 49, no. 13, 2010, pages 2843 - 2850, XP055345667
SATO, M. ET AL.: "Synthesis and evaluation of novel fluorinated sulotroban-related sulfonamide derivatives as thromboxane A2 receptor antagonists", EUR. J. MED. CHEM., vol. 30, 1995, pages 403 - 414, XP004040160
See also references of EP 3321252A4
SATO, M. ET AL.: "Synthesis and evaluation of novel fluorinated sulotroban-related sulfonamide derivatives as thromboxane A2 receptor antagonists", EUR. J. MED. CHEM., vol. 30, 1995, pages 403 - 414, XP004040160
See also references of EP 3321252A4
Attorney, Agent or Firm:
ISHIKAWA Toru et al. (JP)
Download PDF:
Previous Patent: OXIDATION INHIBITOR FOR DIESEL, AND DIESEL FUEL COMPOSITION
Next Patent: COMPOSITION FOR TREATING PERIPHERAL NERVE INJURY
Next Patent: COMPOSITION FOR TREATING PERIPHERAL NERVE INJURY