NOVEL COMPOUND, AND USE THEREOF FOR INHIBITING INTERLEUKIN-1 BETA OR INTERLEUKIN-6

WIPO Patent Application WO/2014/038882

A1

The present invention relates to a compound represented by the following chemical formula 1 or a pharmaceutically acceptable salt thereof, and a composition for preventing or treating STAT3-mediated diseases containing the same as an active ingredient. The compound or a pharmaceutically acceptable salt thereof remarkably inhibits the expression of interleukin-1β (IL-1β) or interleukin-6 (IL-6), and thus can be useful for preventing or treating rheumatoid arthritis, degenerative arthritis, bronchospasm, allergy, inflammatory diseases, autoimmune diseases, destructive bone diseases, infectious diseases, degenerative diseases, necrotic diseases and inflammatory periodontal diseases caused by the activation of the STAT3 pathway by IL-1β or IL-6.

KIM YOUNG KOOK (KR)
NAM JU YEON (KR)
PARK HAE YOUNG (KR)
KIM HYOUNG-CHIN (KR)
KANG JONG SOON (KR)
YOON WOON KEE (KR)
MOON OG SUNG (KR)
LEE CHANG WOO (KR)

PCT/KR2013/008053

March 13, 2014

September 06, 2013

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KOREA RES INST OF BIOSCIENCE (KR)

C07D263/54; A61K31/423; A61P19/00; A61P37/00

WO2011159124A2

2011-12-22

US20040209892A1	2004-10-21
JP2012167027A	2012-09-06

OMORI, NAPKI ET AL.: "Hit to lead SAR study on benzoxazole derivatives for an NPY Y5 antagonist", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 5, 1 March 2012 (2012-03-01), pages 2020 - 2023

SON, MIN (KR)
손민 (KR)

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