Title:
NOVEL COMPOUND WITH INHIBITORY ACTIVITY AGAINST NADPH OXIDASE 2 (NOX2) AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/005506
Kind Code:
A1
Abstract:
The present invention relates to a novel compound with inhibitory activity against NADPH oxidase 2 (NOX2) and a use thereof. The compound of the present invention, an isomer thereof, or a pharmaceutically acceptable salt thereof has the effect of inhibiting NOX2, and thus can be advantageously used for preventing or treating various diseases caused by NOX2, such as inflammatory diseases, neuroinflammatory diseases, adult respiratory distress syndrome, asthma, fibrosis (liver fibrosis, lung fibrosis, etc.), or non-alcoholic steatohepatitis (NASH).
Inventors:
LEE MOO YEOL (KR)
LEE KYEONG (KR)
PARK JUNG MIN (KR)
GODESI SREENIVASULU (KR)
LEE KYEONG (KR)
PARK JUNG MIN (KR)
GODESI SREENIVASULU (KR)
Application Number:
PCT/KR2023/008948
Publication Date:
January 04, 2024
Filing Date:
June 27, 2023
Export Citation:
Assignee:
UNIV DONGGUK IND ACAD COOP (KR)
International Classes:
A61K31/529; A61P1/16; A61P11/00; A61P11/06; A61P25/00; A61P29/00; C07D491/08
Foreign References:
| US20210198269A1 | 2021-07-01 | |||
| KR20060033262A | 2006-04-19 | |||
| US20180009762A1 | 2018-01-11 |
Other References:
KARAGEORGIS GEORGE; RECKZEH ELENA S.; CEBALLOS JAVIER; SCHWALFENBERG MELANIE; SIEVERS SONJA; OSTERMANN CLAUDE; PAHL AXEL; ZIEGLER : "Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3", NATURE CHEMISTRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 10, no. 11, 10 September 2018 (2018-09-10), London, pages 1103 - 1111, XP036618322, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0132-6
PARK, JUNG MIN: "Crosstalk between reactive oxygen species and calcium in vascular smooth muscle angiotensin II signaling.", PH.D. THESIS, DEPARTMENT OF PHARMACY,, DONGGUK UNIVERSITY GRADUATE SCHOOL, KOREA, 1 January 2018 (2018-01-01), Korea, pages 1 - 114, XP009551621
PARK, JUNG MIN: "Crosstalk between reactive oxygen species and calcium in vascular smooth muscle angiotensin II signaling.", PH.D. THESIS, DEPARTMENT OF PHARMACY,, DONGGUK UNIVERSITY GRADUATE SCHOOL, KOREA, 1 January 2018 (2018-01-01), Korea, pages 1 - 114, XP009551621
Attorney, Agent or Firm:
THEWAVE IP LAW FIRM (KR)
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