Title:
NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2000055124
Kind Code:
A3
Abstract:
The present invention relates to novel cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.
More Like This:
Inventors:
BUYSSE ANN M (US)
MENDONCA ROHAN V (US)
PALMER JAMES T (US)
TIAN ZONG-QIANG (US)
VENKATRAMAN SHANKAR (US)
MENDONCA ROHAN V (US)
PALMER JAMES T (US)
TIAN ZONG-QIANG (US)
VENKATRAMAN SHANKAR (US)
Application Number:
PCT/US2000/007145
Publication Date:
August 16, 2001
Filing Date:
March 15, 2000
Export Citation:
Assignee:
AXYS PHARM INC (US)
BUYSSE ANN M (US)
MENDONCA ROHAN V (US)
PALMER JAMES T (US)
TIAN ZONG QIANG (US)
VENKATRAMAN SHANKAR (US)
BUYSSE ANN M (US)
MENDONCA ROHAN V (US)
PALMER JAMES T (US)
TIAN ZONG QIANG (US)
VENKATRAMAN SHANKAR (US)
International Classes:
C07B53/00; C07B61/00; C07C231/02; C07C233/31; C07C235/78; C07C237/08; C07C237/12; C07C237/36; C07C253/30; C07C255/57; C07C269/06; C07C271/22; C07C271/34; C07C273/18; C07C275/24; C07C275/34; C07C275/42; C07C311/03; C07C311/19; C07C313/06; C07C317/28; (IPC1-7): C07C271/20; C07K5/04; C07F9/00; A61K31/325
Domestic Patent References:
| WO1996040647A1 | 1996-12-19 | |||
| WO1996041638A1 | 1996-12-27 | |||
| WO1997003679A1 | 1997-02-06 |
Foreign References:
| US5498616A | 1996-03-12 | |||
| EP0272671A2 | 1988-06-29 |
Other References:
CHEMICAL ABSTRACTS, vol. 131, no. 4, 26 July 1999, Columbus, Ohio, US; abstract no. 45080r, MARQUIS, R W ET AL: "Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K." XP002901313
PATENT ABSTRACTS OF JAPAN vol. 018, no. 542 (C - 1261) 17 October 1994 (1994-10-17)
CHEMICAL ABSTRACTS, vol. 122, no. 23, 5 June 1995, Columbus, Ohio, US; abstract no. 285139z, HARRIS A L ET AL: "Characterization of a continuous fluorogenic assay for calpain I. Kinetic evaluaation of peptide aldehydes, halomethyl ketones and (acyloxy) methyl ketones as inhibitors of the enzyme" page 439; column 2; XP002901314
CHEMICAL ABSTRACTS, vol. 110, no. 7, 13 February 1989, Columbus, Ohio, US; abstract no. 58022q, SAUVE G ET AL: "Carboxyl-modified amino acids and peptides. I An efficient method for the synthesis of mono-functionalized enamines and monofunctionalized methyl ketone derivatives from thioamides via episulfides and thioiminium salts" page 730; column 1; XP002901315
PATENT ABSTRACTS OF JAPAN vol. 018, no. 542 (C - 1261) 17 October 1994 (1994-10-17)
CHEMICAL ABSTRACTS, vol. 122, no. 23, 5 June 1995, Columbus, Ohio, US; abstract no. 285139z, HARRIS A L ET AL: "Characterization of a continuous fluorogenic assay for calpain I. Kinetic evaluaation of peptide aldehydes, halomethyl ketones and (acyloxy) methyl ketones as inhibitors of the enzyme" page 439; column 2; XP002901314
CHEMICAL ABSTRACTS, vol. 110, no. 7, 13 February 1989, Columbus, Ohio, US; abstract no. 58022q, SAUVE G ET AL: "Carboxyl-modified amino acids and peptides. I An efficient method for the synthesis of mono-functionalized enamines and monofunctionalized methyl ketone derivatives from thioamides via episulfides and thioiminium salts" page 730; column 1; XP002901315
Download PDF: