The compounds of the present invention lower plasma glucose, triglycerides, lower total cholesterol (TC) and increase high density lipoprotein (HDL) and decrease low density lipoprotein (LDL), which have a beneficial effect on in cardio vascular disease like coronary heart disease and atherosclerosis.

Description of related art Peroxisome Proliferator Activated Receptors (PPARs) are orphan receptors belonging to the steroid/retinoid receptor super family of ligand activated transcription factors. (Wilson T. M. and Wahli W. , Curr. Opin. Chem. Biol. , 1997, Vol. 1, 235-241). Three mammalian Peroxisome Proliferator Activated Receptors (PPARs) have been isolated and termed PPAR-a, PPAR-y and PPAR-6. These PPARs regulate expression of target genes by binding to DNA sequence elements.

Certain compounds that activate or otherwise interact with one or more of the PPARs have been implicated in the regulation of triglyceride and cholesterol levels in animal models. (U. S. patents 5,847, 008; 5,859, 051 and PCT publications WO 97/28149; WO 99/04815.

Weak PPARa agonists such as fibrate class of compounds correct atherogenic dyslipoproteinemia. Several angiographic intervention trials have demonstrated a beneficial action of these drugs on atherosclerotic lesion progression and results from primary and secondary prevention trials show a decreased incidence of cardiovascular events. (Ricote M. and Glass C. K.; Trends in Pharmacological Sciences; 2001; 22 (9); 441-443.

Despite the fact that fibrates, which are weak PPAR-a activators, reduce the plasma triglyceride levels and elevate the levels of HDL-C simultaneously, they are not the drugs of choice, because of low efficacy requiring high doses, incidence of Myositis and contra-indicated in patients with impaired renal and hepatic function and to pregnant and nursing women.

However there has been rapid progress in our understanding on the role of PPAR-a in different pathophysiological conditions in addition to the well-documented favourable effects on lipid profile. The inflammatory activation of aortic smooth muscle cells, which is the hallmark of atherosclerosis, seems to be inhibited by the enhanced PPAR-a activity.

(Vamecq J. and Latruffe N ; Lancet; 1999; 354; 141-148) Recent evidence suggests the role of PPAR-a receptors in improving insulin sensitivity. It has been demonsrated that by lowering circulatory and muscle lipids in insulin-resistant rodent models such as obese Zuker rats, high fat-fed mice and sucrose-lard fed rats, PPAR-a ligands improve insulin sensitivity and obesity. Further the lipid lowering activity of the statins has been linked to a cross talk with PPAR-a receptor in addition to limited cholesterol availability. Some clinical trials have shown improvement in insulin sensitivity indices, wherein fibrates were employed. (i. Guerre-Millo M, Rounalt C. and Poulain P; Diabetes; 2001; 50; 2809-2814, ii. Muoio D. M. , Way J. M. and Tanner C. J.; Diabetes; 2002; 51; 901-909, iii. Ye J, Doyle P. J. and Iglesias M. A.; Diabetes; 2001; 50; 411-417, iv. Roglans N, Sanguino E. and Peris C; JPET; 2002; 302; 232-239.

Thus there is an interesting evidence for PPAR-a agonists to be used for lipid control and as per recent evidence even for insulin resistance. Limitations of the currently available medications coupled with the fact that lipid abnormalities are on the rise world over necessitate the discovery of more potent and safer PPAR-a agonists. In continuation of our research work on PPAR agonists (U. S. Patents 5,885, 997; 6,054, 453; 6,265, 401: PCT application PCT/IB02/04275) to address this unmet need, a series of compounds have been synthesized which has been disclosed in the present invention.

The patent application WO 98/31359 describes substituted aromatic or non aromatic ring systems as vitronectin receptor antagonists. GB 2202223 describes sulfonylcarboxamides for the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions. US patent 600117 and 6399620 describes imino derivatives as vitronectin receptor antagonists and also as inhibitors of bone resorption.

GB 2310669 describes substituted aromatic or non aromatic ring systems as a liquid crystalline medium. WO 92/01675 describes substituted bicyclic bis-aryl compounds which exhibit selective leukotriene B4 antagonist activity. WO 01/53257 describes substituted pyrrole derivatives having hypolipedemic, hypocholesteremic activities.

Summary of the Invention The present invention is directed to novel compounds, their pharmaceutically acceptable salts capable of being used as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic agents.

The present invention also directed to methods for the production of the compounds of the present invention. The present invention also directed pharmaceutical composition which includes the compound of the present invention. The present invention is directed to methods for the treating diabetes, dyslipidemia,. hypercholesterolemia, obesity and hypertriglyceridemia.

One aspect of this invention provides novel compounds of formula (I) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions.

One aspect of the present invention provides novel compounds of formula (Ia). their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions.

One aspect of the present invention provides novel compounds of formula (Ib). their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions.

One aspect of the present invention provides novel compounds of formula (Ib). their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions.

One aspect of the present invention provides novel compounds of formula (Id) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions.

One aspect of the present invention provides novel compounds of formula (Ie) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions.

One aspect of the present invention provides novel compounds of formula (If) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions.

Further exemplifying the invention is a pharmaceutical composition comprising any of the compounds described above and a pharmaceutically acceptable carrier. Another illustration of the invention is a process for making a pharmaceutical composition comprising combining any of the compounds described above and a pharmaceutically acceptable carrier.

Further illustrating the invention is method for treatment and/or prophylaxis of a condition that requires an agonist of peroxisome proliferator activated receptor in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of any of the compounds described above. Preferably the condition is selected from insulin resistance and dyslipidemia. such as diabetes, hypertension, coronary heart disease, atherosclerosis, stroke, peripheral vascular diseases, psoriasis, polycystic ovarian syndrome (PCOS), inflammatory bowel diseases, osteoporosis, myotonic dystrophy, pancreatitis, retinopathy, arteriosclerosis, xanthoma and related disorders.

Another illustration of the invention is method for treatment and/or prophylaxis of the above mentioned diseases using the compounds of the present invention in combination/concomitant with one or more HMG CoA reductase inhibitor; cholesterol absorption inhibitor; antiobesity drug; lipoprotein disorder treatment drug; hypoglycemic agents: insulin; biguanide; sulfonylurea ; thiazolidinedione; dual PPARa and y or a mixture thereof. The compounds of the present invention in combination with HMG CoA reductase inhibitor, cholesterol absorption inhibitor, antiobesity drug, hypoglycemic agent can be administered together or within such a period to act synergistically.

Further exemplifying the invention is a pharmaceutical composition, containing the compounds the present invention as defined above, their pharmaceutically acceptable salts and one or more HMG CoA reductase inhibitor; cholesterol absorption inhibitor; antiobesity drug; lipoprotein disorder treatment drug; hypoglycemic agents: insulin; biguanide; sulfonylurea; thiazolidinedione ; dual PPARa and y or a mixture thereof in combination with the usual pharmaceutically employed carriers, diluents and the like.

Detailed description of the invention Accordingly the present invention provides compounds of general formula (I), their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions. wherein ring"Arl"represents a monocyclic or polycyclic aromatic or partially saturated aromatic polycyclic, which may optionally contain up to 3 heteroatoms selected from N, S or O. preferably The said monocyclic or polycyclic ring may be unsubstituted or have up to 4 substituents which may be identical or different; m and n independently represents an integer from 0 to 6; A represents O, S or a bond; Y is selected from (CH2) p, (CH2) pB (CH2) q, (CH2) rB (CH2) pD (CH2) q, where p, q and r each independently represents an integer from 0 to 6; B and D independently represents S, O, NR4 or a bond, with a proviso that when B and D represents hetero atom p is not zero; R4 represents hydrogen, alkyl, alkenyl, alkynyl,-S (O) 2-R8 or-C (O) R8 where R8 is alkyl, alkoxy; R and R6 independently represents hydrogen, alkyl, cycloalkyl or alkoxy; R5 and R6 together may form 3-8 membered cyclic ring which may optionally contains one or two hetero atoms selected from O, S or N; R7 represents hydrogen, optionally substituted groups selected form alkyl, cycloalkyl, alkenyl or alkynyl The substituent on ring"Arl"is selected from halo, nitro, alkyl, hydroxy, hydroxy alkyl, alkoxy, thioalkoxy, oxo, aryl,-NRlR2,-OCONR'R2, NRCOOR2,-NR'CORZ,- NR1SO2R2, NR1CONR1R2, -SOS2R3, -SO2R3.

R1 and R2 independently represents hydrogen, optionally substituted groups selected from alkyl, alkenyl, alkynyl, cylcoalkyl, heterocyclyl, aryl, heteroaryl.

R3 independently represents hydrogen, optionally substituted groups selected from alkyl, alkenyl, alkynyl, cylcoalkyl, heterocyclyl, aryl, heteroaryl.

Substitutents on Rl, R2, R3 and R7 are selected from hydrogen, halo, nitro, amino, mono or di substituted amino, hydroxy, alkoxy, carboxy, cyano, alkyl, cycloalkyl, alkoxy, haloalkoxy, haloalkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl.

One embodiment of the present invention is a compound of formula (I) as described by formula (Ia) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions. wherein"Arl"represents optionally substituted group selected from p and m independently represents an integer from 0 to 6; B represents S, O or NR4 or a bond; The substituent on ring"Arl"is selected from halo, nitro, alkyl, hydroxy, hydroxy alkyl, alkoxy, thioalkoxy, oxo, aryl,-NR'R2,-OCONR'R2, NR'COOR2,-NR'COR2,- NR'SO2R2, NR'CONRR2,-OSO2R3,-SO2R3.

And all other symbols are as defined above.

Representative compounds in accordance with the present invention are presented in Table 1. This table is not intended to be exclusive of the compounds of the present invention, but rather exemplary of the compounds of formula (Ia), that are encompassed by this invention.

Table 1 S. No. Structure IUPAC Name 1. CO2Et (S)-Ethyl 2-methoxy-3- [4- {6- H oMe methanesulfonyloxynapth-2- ylmethylamino} phenyl] propanoate Sk H Me 2. I CO2Et Ethyl 2-ethoxy-3- [4- {6- oEt methanesulfonyloxynapth-2- (i H ylmethylamino} phenyl] propanoate A H Me 3. IC02Et Ethyl 2-ethoxy-5- [4- {6- 0 O wNAJ OEt methanesulfonyloxynapth-2- , lmethylamino} phenyl] pentanoate Me 0 Ethyl 2-ethoxy-3- [4- {3- (indol-1-yl) uN, tCO2Et propyl amino} phenyl] propanoate OEt ) H (Methyl 2-methoxy-3- [4- {3- COOMe (indol-1-yl) propylamino} phenyl] propanoate OMe H H (S)-Ethyl-2-ethoxy-3- [4- {3- (5- °"° m methanesulfonyloxyindol-1-yl) N i 2 propylamino} phenyl] propanoate I OEt H 7 Mess, O S)-Methyl-2-methoxy-3- [4- {3- (5- S Co Me methanesulfonyloxyindol-1-yl) propylamino} phenyl] propanoate r' OMe H g. Mes, (S)-Methyl 3-ethoxy-4- [4- {3- (5- 0 methanesulfonyloxyindol-1-yl) C02Me propylamino} phenyl] butanoate k.. , JJ OEt N H 9. Ethyl 2-ethoxy-3- [4- {3- (2, 3- C02Et dihydroindol-1-yl) propylamino} '' 2 i ii phenyl] propanoate OEt H H 10. Ethyl 2-ethoxy-3- [4-{(6- ~ NJA2J OEt methanesulfonyloxy-l, 2, 3, 4- °> ° I | tetrahydronapth-2-yl) methylamino} Me'S, phenyl] propanoate -'y C02Et Ethyl 2-ethoxy-3- [4- {3- (6-methane o,, o N OE't sulfonyloxy-1, 2, 3, 4- , StOv H tetrahydronapth-2-yl) propylamino} s. H Y P Y) P PY Me phenyl] propanoate 12. Ethyl 2-ethoxy-3- [4-, {3- (1, 2, 3, 4- No C02Et tetrahydroquinolyn-1-yl) propylamino} phenyl] propanoate \ I OEt ) H 13. CO2H (S)-2-methoxy-3- [4- {6- bme methanesulfonyloxynapth-2-. S o [% J N ylmethylamino} phenyl] propanoic acid 14. f, CO2H 2-ethoxy 3 OEt methanesulfonyloxynapth-2- N ylmethylamino) phenyl] propanoic acid Mu 15. co2H 2-Ethoxy-5- [4- {6- oEt methanesulfonyloxynapth-2- ylmethylamino} phenyl] pentatonic Me"'acid Me. o acid 16. 2-ethoxy-3- [4- {3- (indol-1-yl) propyl amino} phenyl] propanoic acid OEt H H 17. (S)-2-methoxy-3- [4- {3- (indol-1-yl) propyl amino} phenyl] propanoic acid W I OMe H H 18. Me,. O. (S)-2-ethoxy-3- [4- {3- (5- methanesulfonyloxyindol-1-yl) ac dylamino} phenyl] propanoic N) OEt acid H H 19. Me, o S)-2-methoxy-3- [4- {3- (5- °" methanesulfonyloxyindol-1-yl) i zH propylamino} phenyl] propanoic N OMe acid H H 20. Mess, O S)-3-ethoxy-4- [4-{3-(5- methanesulfonyloxyindol-I-yl) RN vCO2H propylamino} phenyl] butanoic acid k.,, J OEt OEt H 21. 2-ethoxy-3- [4- {3- (2, 3- uN H dihydroindol-1-yl) propylamino} phenyl propanoic acid N OEt t H 22. f, CO2H 2-ethoxy-3- [4-{(6- ~ U OEt methanesulfonyloxy-l, 2, 3, 4- N tetrahydronapth-2-yl) methylamino} me, 0,-00 phenyl] propanoic acid 23. CH 2-ethoxy-3- [4- {3- (6- oEt methanesulfonyloxy-1, 2, 3, 4- tetrahydronapth-2-yl) propylamino} Me phenyl] propanoic aci 24. 2-ethoxy-3- [4-f3- (I, 2, 3, 4- COOH tetrahydroquinolyn-1-yl) propylamino} phenyl] propanoic w OEt acid H H 25. coo H2N N spso2H (S)-2-methoxy-3- [4- {6- o 0, <<N><OMe sNH2 NH2 methanesulfonyloxynapth-2- ylmethylamino} phenyl] propanoic acid Arginine salt 26., ~f Y NH2 2-Ethoxy-5- [4- {6-methanesulfonyl ""'oxynapth-2-ylmethylamino} phenyl] o,,. o Me H pentatonic acid Arginine salt O H p2H 2-ethoxy-3- [4- {3- (indol-1-yl) coz HZN NNHZ propyl amino} phenyl] propanoic N (-) NH2 acid Arginine salt H 28. on (D H C% H (S)-2-methoxy-3- [4- {3- (indol-1-yi) propyl amino} phenyl] propanoic Q+ NHZ acid Arginine salt H 29. esS ow (S)-2-ethoxy-3- [4- {3- (5- C02 H, N H, methanesulfonyl oxyindol-I-yl) N NH2 propylamino) phenyl] propanoic acid Arginine salt 30. Me,-0 (S)-2-methoxy-3- [4- {3- (5- methanesulfonyl oxyindol N OMe ONH2 propylamino} phenyl] propanoic "acid Arginine salt 31. o- (S)-3-ethoxy-4- [4- {3- (5- uN H N N COyH methanesulfonyloxyindol-1-yl) N" °' propylamino} phenyl] butanoic acid "Arginine salt 32. ( 0 n co, n 2-ethoxy-3- [4- {3- (2, 3- Y N",-)-NH2 dihydroindol-I-yl) propylamino) II OE't ONH2 phenyll propanoic acid Arginine salt H 33. H 2-ethoxy-3- [4- { (6- ° o OEt sNH2 NH2 methanesulfonyloxy-l, 2, 3, 4- Me, H tetrahydronapth-2-yl) methylamino} phenyl] propanoic acid Arginine salt 34. eH X. 2"2-ethoxy-3- [4-f3- (6- O O l<NJnEt (DNH2 NH2 methanesulfonyloxy-l, 2, 3, 4- S'wV H tetrahydronapth-2-yl) propylamino} phenyl] propanoic acid Arginine salt 35. co2"2-ethoxy-3- [4- {3- (1, 2, 3, 4- N CO H2N yN tetrahydroquinolyn-I-yl) OEt NH2 propylamino} phenyl] propanoic "acid Arginine salt Another embodiment of the present invention is a compound of formula (Ia) where "Arl"is substituted with-OSO2R3, wherein R3 is as defined above preferably optionally substituted groups selected from alkyl or aryl.

And all other symbols are as defined above.

Another embodiment of the present invention is a compound of formula (I) as described by formula (Ib) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions. wherein"Ar,"represents optionally substituted group selected from p and m independently represents an integer from 0 to 6; B represents S, O or NR4 or a bond; The substituent on ring"Arl"is selected from halo, nitro, alkyl, hydroxy, hydroxyalkyl, alkoxy, thioalkoxy, oxo, aryl, -NR1R2, -OCONR1R2, NR'COOR,- NR'COR2,-NR'SO2R2, NR'CONR'R2,-OSO2R3,-SOZR3.

And all other symbols are as defined above.

Representative compounds in accordance with the present invention are presented in Table 2. This table is not intended to be exclusive of the compounds of the present invention, but rather exemplary of the compounds of formula (Ib), that are encompassed by this invention.

Table 2 S. No. Structure IUPAC Name 2 tEthyl 2-methyl-2- [4- {6- O o mf Nw methanesulfonyloxynapth-2- Me ylmethylamino} phenoxy] propanoate 2. Me'0 Ethyl 2-methyl-2- [4- {3- (5- o co2Et methanesulfonyloxyindol-1-yl) N, JS propylamino} phenoxy] propanoate H O COOH 3. 0 COOH 2-methyl-2- [4-10- o o mf Nw methanesulfonyloxynapth-2- mye w ylmethylamino} phenoxy] propanoic acid 4. Me ,, o 2-methyl-2- [4- {3- (5- o coZH methanesulfonyloxyindol-1-yl) H propylamino} phenoxy] propanoic acid Another embodiment of the present invention is a compound of formula (Ib) where "Arl"is substituted with -OSO2R3, wherein R3 is as defined above preferably optionally substituted groups selected from alkyl or aryl.

And all other symbols are as defined above.

Another embodiment of the present invention is a compound of formula (I) as described by formula (Ic) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions. wherein"Arl"represents optionally substituted group selected from p and m independently represents an integer from 0 to 6; B represents S, O or NR4 or a bond; The substituent on ring"Arl"is selected from halo, nitro, alkyl, hydroxy, hydroxyalkyl, alkoxy, thioalkoxy, oxo, aryl,-NR'R2,-OCONRlR2, NRCOOR, NR'COR2,-NR'SO2R2, NR'CONRR2,-OSO2R3,-S02R3.

And all other symbols are as defined above.

Another embodiment of the present invention is a compound of formula (Ic) where "Ar"is substituted with-OSOzR3, wherein R3 is as defined above preferably optionally substituted groups selected from alkyl or aryl.

And all other symbols are as defined above.

Another embodiment of the present invention is a compound of formula (I) as described by formula (Id) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions. wherein"Arl"represents optionally substituted group selected from p and m independently represents an integer from 0 to 6; B represents S, O or NR4 or a bond; The substituent on ring"Arl"is selected from halo, nitro, alkyl, hydroxy, hydroxyalkyl, alkoxy, thioalkoxy, oxo, aryl, -NR1R2, -OCONR1R2, NR'COOR,- NR'COR2,-NR'SOZR2, NR'CONR'R2,-OSOZR3,-S02R3.

And all other symbols are as defined above.

Representative compounds in accordance with the present invention are presented in Table 3. This table is not intended to be exclusive of the compounds of the present invention, but rather exemplary of the compounds of formula (Id), that are encompassed by this invention.

Table 3 S. No. Structure IUPAC Name 0, C02E' Ethyl 2-methyl-2- [4- {6- methanesulfonyloxynapth-2- MeXo ylmethoxy} phenoxy] propanoate 2. Me, 0 Ethyl 2-methyl-2- [4- {3- (5- °§ò co2Et methanesulfonyloxyindol-1-yl) "\ propyloxy) phenoxy] propanoate Ethyl 2-methyl-2- [4- {3- (4- Moo'cor methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoate ><02Et Ethyl 2-methyl-2- [3- {3- (3- methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoate 5.oXcooH 2-methyl-2- [4- {6- methanesulfonyloxynapth-2- ylmethoxy} phenoxy] propanoic acid 6. es °< 2-methyl-2- [4-{3-(5- CO H methanesulfonyloxyindol-1-yl) propylo) phenoxy] propanoic acid 0 7. 2-Methyl-2- [4- {3- (4- methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoic acid 8. oo oco2H 2_Methyl-2- [3- {3- (3- methanesulfonyloxyphenoxy) propylo xy} phenoxy] propanoic acid 9. D e, c 2-methyl-2- [4- {3- (5- Nu 2 iN Y ~NH2 methanesulfonyloxyindol1yl) propyloxy} phenoxy] propanoic acid Arginine salt 10. S £> g0> NH 2Methyl2 [4 {3 (4 . s. o- .. yC, o-'o methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoic acid Arginine salt 11. oNa= 2-Methyl-2- [3- {3- (3- ""ogo, °-°°X°= ""= methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoic acid Arginine salt 12. o. o o co2e gyl2-methyl-2- [3- {3- (4- mso methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoate 13. o Os Op<CO2H 2-Methyl-2-[3-{3-(4- Mso methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoic acid 14. - 2-Methyl-2- [3- {3- (4- 0. methanesulfonyloxyphenoxy) o>-° i i propyloxy} phenoxy] propanoic acid Arginine salt 15. o,,. o j°--°Y-°'Ethyl 2-methyl-2- [3- {3- (4- (para- toluenesulfonyloxy) phenoxy) propylo 'xy} phenoxy] propanoate 16. o o, ¢> Ethyl 2-methyl-2-[4- {3-(4- MezvO O CO2Et methanesulfonyloxyphenoxy) propylo xy} phenoxy] butanoate 17. o,.. oj (°-°Y°X 2-methy !-2- [3- {3- (4- (pa- toluenesulfonyloxy) phenoxy) propylo 'xy} phenoxy] propanoic acid . 18. (2Co~on} 2-Methyl-2-[4-{3-(4- I'o"coZH methanesulfonyloxyphenoxy) propylo xy} phenoxy] butanoic acid 19. - 2-Methyl-2- [3- {3- (4- (para- toluenesulfonyloxy) phenoxy) propylo , °''xy} phenoxy] propanoic acid, arginine salt salt "2-Methyl-2- [4- {3- (4- _C methanesulfonyloxyphenoxy) propylo xy} phenoxy] butanoic acid, arginine salt Another embodiment of the present invention is a compound of formula (Id) where "Arl"is substituted with-OSO2R3, wherein R3 is as defined above preferably optionally substituted groups selected from alkyl or aryl.

Another embodiment of the present invention is a compound of formula (I) as described by formula (Ie) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions. wherein"Ar"represents optionally substituted group selected from p and m independently represents an integer from 0 to 6; B represents S, O or NR4 or a bond; The substituent on ring"Art"is selected from halo, nitro, alkyl, hydroxy, hydroxyalkyl, alkoxy, thioalkoxy, oxo, aryl,-NR'R2,-OCONR'Rz, NR'COOR2,- NR'COR2,-NR'SO2R2, NR'CONR'R2,-OSO2R3,-SO2R3.

And all other symbols are as defined above.

Another embodiment of the present invention is a compound of formula (Ie) where "Arl"is substituted with with -OSO2R3, wherein R3 is as defined above preferably optionally substituted groups selected from alkyl or aryl.

And all other symbols are as defined above.

Another embodiment of the present invention is a compound of formula (I) as described by formula (If) their derivatives, their stereoisomers, their phamaceutically acceptable salts and their pharmaceutically acceptable compositions. wherein"Arl"represents optionally substituted group selected from p and m independently represents an integer from 0 to 6; B represents S, O or NR4 or a bond; The substituent on ring"Arl"is selected from halo, nitro, alkyl, hydroxy, hydroxyalkyl, alkoxy, thioalkoxy, oxo, aryl, -NR1R2, -OCONR1R2, NR1COOR2, - NR'COR2,-NR'SO2R2, NR'CONR'R2,-OSO2R3,-S02R3.

And all other symbols are as defined above.

Representative compounds in accordance with the present invention are presented in Table 4. This table is not intended to be exclusive of the compounds of the present invention, but rather exemplary of the compounds of formula (If), that are encompassed by this invention.

Table 4 S. No. Structure IUPAC Name 1 Mess, O Ethyl 2-methyl-2- [4- {3- (5- oll, b methanesulfonyloxyindol-I-yl) propyl} phenoxy] propanoate OCOpEt 2. Ethyl 2-methyl-2- [4- {3- (3, 4- dihydro-2H-bezo [b] [1, 4] Oxazin- 4-yl) propyl} phenoxy] propanoate Ll, 4 v v O CO2Et 3. Ethyl 2-methyl-2- [4- {3- (3- methanesulfonyloxyphenoxy) propyl} phenoxy] propanoate 0 COzEt 4. mso Ethyl 2-methyl-2- [3- {3- (4- Wo Et methanesulfonyloxyphenoxy) propyl} phenoxy] propanoate 5. Me, 0 2-methyl-2- [4- (3- (5- 0 methanesulfonyloxyindol-1-yl) propyl} phenoxy] propanoic acid WOXCOOH OxCOOH 6.. 0 2-methyl-2- [4- {3- (3, 4-dihydro- ) 2H-bezo [b] [1, 4] Oxazin-4-yl) N propyl} phenoxy] propanoic acid 11 1 X 90 COOH 7. r 2-Methyl-2- [4- {3- (3- msoao methanesulfonyloxyphenoxy) propyl} phenoxy] propanoic acid ° CO2H 8. MsO 2-Methyl-2- [3- (3- (4- -0, 0 0 C02H methanesulfonyloxyphenoxy) propyl} phenoxy] propanoic acid 9. 2-methyl-2- [4- (3- (5- metlianesulfonyloxyindol-I-yl) o NH= propyl} phenoxy] propanoic acid ont2 Arginine salt 10. Sog 2-methyl-2-14- {3-(3, 4-dihydro-2H- N CO2H bezo [b] [1, 4] Oxazin-4-yl) propyl} N=N p e Y 1-----J'NH2 phenoxy] propanoic acid Arginine ocoo OO NHZ salt JO., , 2-Methyl-2- [4- {3- (3- C yt4"methanesulfonyloxyphenoxy) propyl} phenoxy] propanoic acid Arginine salt 12. Mevs o Ethyl 2-methyl-2- [3- {3- (5- 0 Ò > methanesulfonyloxyindol-l-yl) propyl} phenoxy] propanoate W I 13. me, o 2-methyl-2- [3- {3- (5- o"methanesulfonyloxyindol-1-yl) propyl} phenoxy] propanoic acid ^^/OC02H 14. 2-methyl-2- [3- {3- (5- N o , methanesulfonyloxyindol-1-yl) < sNH, propyl} phenoxy] propanoic acid / . p NHi Arginine salt 15. H3. o o Ethyl-2-methyl-2- [3- {3- (7- ebb Methanesulfonyloxy-3, 4-dihydro- 2H-bezo [b] [1, 4] oxazin-4-yl) O COzEt propyl} phenoxy] propanoate. 16. 9 (+) Methyl (R)-2-methyl-2- [4- {3- Me-s' (5-methanesulfonyloxyindol-1- 1, O yl) propyl} phenoxy] butanoate (-) Methyl (, S-2-methyl-2- [4- {3- (5- MeocoocH, methanesulfonyloxyindol-1- , to \ yl) propyl} phenoxy] butanoate 18. 0,, 0 0 Ethyl 2-methyl-2- [4- {4- (4- so > a Wo5tCo2Et methanesulfonyloxyphenoxy) butyl} phenoxy] propanoate 19. Ethyl 2-methyl-2- [3- 5- (4- 0,,'0 o--cO2EI methanesulfonyloxyphenoxy) pentyl M8 S'o phenoxy] propanoate 20. oxco2EC Eyl2-methyl-2- [3- {5- (4- nitrophenoxy) propyl} phenoxy] prop j !. J anoate ozon 21.. YcOzEt Ethyl 2-methyl-2- [3- {5- (4- aminopheiioxy) propyl) phenoxylpro Hz panoate Han 22. OK102E'Ethyl 2-methyl-2- [4- f 3- (4- (tert- ° butyloxycarbonylamino) phenoxy) pr opal} phenoxy] propanoate H 23. oco, E. Ethyl 2-methyl-2- [4- {3- (4- o o A (methanesulfonylamino) phenoxy) pr I me N v opyl} phenoxy] propanoate Me 24. me, Ethyl 2-methyl-2- [4- {4- (5- o'ò co cc methanesulfonyloxyindol-1- yl) butyl) phenoxylpropanoate 25. Ethyl 2-methyl-2- [3- (3- (5- (para- < o toluenesulfonyloxy) indol-I- o So \ yl) propyl} phenoxy] propanoate N 0 CO2Et WA J 26. me, o Ethyl 2- [3- {3- (5- -CON\ methanesulfonyloxyindol-1-yl) propyl} phenoxy] propanoate ocozE I 27. s w 1-[4-{3-(5- °"ò t 3 Methanesulfonyloxyindol-1- Nl yl) propyl} phenoxy] cyclohexane-I- J carboxylic acid, methyl ester O CO2Me 28. me, o 1- [4-13- (5- Oo methanesulfonyloxyindol-l- Nl yl) propyl} phenoxy] cyclopentane-1- carboxylic acid, methyl ester O CO2Me 29."'8S ; o 1 _ (4_ {4_5_ methanesulfonyloxyindol-1- v o coZnne yl) butyl) phenoxy] cyclopentane-l- carboxylic acid, methyl ester 30. me, o 0 1- [4-13- (7-Methanesulfonyloxy-3, 4-dihydro-2H-bezo [b] [1, 4] oxazin-4- yl) propyl} phenoxy] cyclopentane-1- o co2Me carboxylic acid, methyl ester 31. , ooEthyl 2-methyl-2- [4- {4- (7- ° C02Et methanesulfonyloxy-3, 4-dihydro- 2H-bezo [b] [1, 4] oxazin-3-on-4- yl) butyl} phenoxy] propanoate 32. H3C, 0,, ao 2-Methyl-2- [3-f3- (7- Methanesulfonyloxy-3, 4-dihydro- OOH 2H-bezo [b] [1, 4] oxazin-4-yl) propyl) phenoxy] propanoic acid 33. COOH (R)- (+)-2-methyl-2- [4- (3- (5- 10 methanesulfonyloxyindol-1-yl) 0-10 propyll phenoxy] butanoic acid 34. \N'N H (S)- (-)-2-methyl-2- [4- {3- (5- Me-'-N wzo cooH methanesulfonyloxyindol-1- to \ yl) propyl} phenoxy] butanoic acid 35. zu o ° 2-Methyl-2- [4- {4- (4- oS>ow WoXco2H methanesulfonyloxyphenoxy) butyl} phenoxy] propanoic acid 36. 2-Methyl-2- [3- {5- (4- o,,., o ocoH methanesulfonyloxyphenoxy) pentyl is ~} phenoxy] propanoic acid 37. 2-Methyl-2- [4- f 3- (4- (tert- o K>-° butyloxycarbonylamino) phenoxy) pr opyl} phenoxy] propanoic acid H 38. 0 C02H 2-Methyl-2- [4-13- (4- Ol'O (methanesulfonylamino) phenoxy) pr o,,,, o o"opyl} phenoxy] propanoic acid mye 39. Me, S'O 2-Methyl-2- [4- {4- (5- 02H methanesulfonyloxyindol- < lyl) butyl} phenoxy] propanoic acid 40. 2-Methyl-2- [3- {3- (5- (para- toluenesulfonyloxy) indol-l- OSÓ yl) propyl} phenoxy] propanoic acid WA 41. me, o 2- [3- {3- (5- ° ° JL/Methanesulfbnyloxyindol-l- yl) propyl} phenoxy] propanoic acid , OtCO2H 42. ^^eS : 0 1_4_ {3_ (5_ ° . methanesulfonyloxyindol-1- yl) propyl} phenoxy] cyclohexane-l- carboxylic acid 90 CO2H 43. 1- [4- {3- (5- 0Ò > Methanesulfonyloxyindol-1- yl) propyl} phenoxy] cyclopentane-1- carboxylic acid 0 C02H 44. ^^e. s. o _ o co2H methanesulfonyloxyindol-1- 6 YI) butyl) phenoxy] cyclopentane-1- carboxylic acid 1- [4- f3- (7-Methanesulfonyloxy-3, 0-aN) 4-dihydro-2H-bezo [b) [1, 4] oxazin-4-yl) propyl) phenoxy] i > Q cyclopentane-l-carboxylic acid o'coZH e 0 2-Methyl-2- [4- (4- (7- o' No o cozH methanesulfonyloxy-3, 4-dihydro- 2H-bezo [b] [1, 4] oxazin-3-on-4- yl) butyl} phenoxy] propanoic acid 47. : o \, ° 2-Methyl-2- [3- {3- (7- of OxCOtHaN N~ Methanesulfonyloxy-3, 4-dihydro- 2H-bezo [b] [1, 4] oxazin-4-yl) propyl} phenoxy] propanoic acid, Arginine salt 48", - Hr ()- (+)-2-methyl-2- [4- {3- (5- ""°'o o r""° methanesulfonyloxyindol-1-yl) propyl} phenoxy] butanoic acid, Arginine salt 49. , -" H.-r" ()- (-)-2-methyl-2- [4- {3- (5- y methanesulfonyloxyindol-I-yl) propyl} phenoxy] butanoic acid, Arginine salt 50. M {+ wN O Cooo (racemic) Methyl-2-methyl-2- [4- {3- (5-methanesulfonyloxyindol-1- yl) propyl} phenoxy] butanoic acid Magnesium salt S1. o \ H7NUNN 2-Methyl-2- [4- {4- (4- qip---Q. \"Cop ONh methanesulfonyloxyphenoxy) butyl} phenoxy] propanoic acid, arginine salt 52. HyN NNH, 2-Methyl-2- [3- {5- (4- 0 cc) 2 methanesulfonyloxyphenoxy) pentyl } phenoxy] propanoic acid, arginine salt 53. YK COON 2-Methyl-2- [4-14- (5-methane > °XCt sulfonyloxyindollyl) butyl} phenoxy] propanoic acid, arginine salt 54. HN 2-Methyl-2- [3- f 3- (5- (para- o. H toluenesulfonyloxy) indol-1- O \ I H 11 N NH : N o CO @NHX yl) propyl} phenoxy] propanoic acid, arginine salt 55., osQ, N Methanesulfonyloxyindol-1- a T yl) propyl} phenoxy] propanoic acid, arginine 56. Me. 0 1- [4-13- (5- methanesulfonyloxyindol-1- yl) propyl} phenoxy] cyclohexane-1- carboxylic acid, magnesium salt 57. fr 1 1-- {3- (5- Methanesulfonyloxyindol-1- yl) pTopyl} phenoxy] cyclopentane-l- 0 ° co, ! carboxylic acid, magnesium salt CDC 61bo 0 (D NH. methanesulfonyloxyindol-1- yl) butyl} phenoxy] cyclopentane-1- carboxylic acid, arginine salt 59. Me, 1- [4- {3- (7-Methanesulfonyloxy-3, Ms2+ o N 4-dihydro-2H-bezo [b] [1, 4] oxazin-4- ° C°2 2 yl) propyl} phenoxy] cyclopentane-l- carboxylic acid, magnesium salt 60. H G. NHs 2-Methyl-2- [4- {4- (7- Mev5 °g° co20 @tH, 2 methanesulfonyloxy-3, 4-dihydro- C°j0°'2-bezo [6] [1, 4] oxazm-3-on-4- yl) butyl} phenoxy] propanoic acid, Arginine salt Another embodiment of the present invention is a compound of formula (If) where "Arl"is substituted with-OSOzR3, wherein R3 is as defined above preferably optionally substituted groups selected from alkyl or aryl.

And all other symbols are as defined above.

Compounds of the present invention are agonists or peroxisome proliferators activated receptor (PPAR) and hence are useful for the treatment or prophylaxis of patients suffering from a condition caused by the non activation of PPAR, who are in need of such therapy. Pharmacologically effective amounts of the compounds, including pharmaceutically acceptable salts thereof, are administered to the patient to inhibit insulin resistance and dyslipidemia such as diabetes, hypertension, coronary heart disease, atherosclerosis, stroke, peripheral vascular diseases, psoriasis, polycystic ovarian syndrome (PCOS), inflammatory bowel diseases, osteoporosis, myotonic dystrophy, pancreatitis, retinopathy, arteriosclerosis, xanthoma and related disorders.

The compounds of the present invention are administered in dosages effective to agonize peroxisome proliferators activated receptor where such treatment is needed, as, for example, in the prevention or treatment of diabetes, hypertension, coronary heart disease, atherosclerosis, stroke, peripheral vascular diseases, psoriasis, polycystic ovarian syndrome (PCOS), inflammatory bowel diseases, osteoporosis, myotonic dystrophy, pancreatitis, retinopathy, arteriosclerosis, xanthoma and related disorders. For use in medicine, the salts of the compounds of this invention refer to non-toxic "pharmaceutically acceptable salts. "Other salts may, however, be useful in the preparation of the compounds according to the invention or of their pharmaceutically acceptable salts.

Salts encompassed within the term"pharmaceutically acceptable salts"refer to non-toxic salts of the compounds of this invention which are generally prepared by reacting the free acid with a suitable organic or inorganic base. Representative salts include the following: Li, Na, K, Ca, Mg, Fe, Cu, Zn, Mn; N, iylenediamine, betaine, caffeine, 2-diethylaminoethanol, 2-dimethylaminoethanol, N-ethylmorpholine, N- ethylpiperidine, glucamine, glucosamine, hydrabamine, isopropylamine, methylglucamine, morpholine, piperazine, piperidine, procaine, purines, theobromine, triethylamine, trimethylamine, tripropylamine, tromethamine, diethanolamine, meglumine, ethylenediamine, N, N'-diphenylethylenediamine, N, N'-dibenzylethylenediamine, N- benzyl phenylethylamine, choline, choline hydroxide, dicyclohexylamine, metformin, benzylamine, phenylethylamine, dialkylamine, trialkylamine, thiamine, aminopyrimidine, aminopyridine, purine, spermidine ; alkylphenylamine, glycinol, phenyl glycinol; glycine, alanine, valine, leucine, isoleucine, norleucine, tyrosine, cystine, cysteine, methionine, proline, hydroxy proline, histidine, ornithine, lysine, arginine, serine, threonine, phenylalanine; unnatural amino acids; D-isomers or substituted amino acids; guanidine, substituted guanidine wherein the substituents are selected from nitro, amino, alkyl, alkenyl, alkynyl, ammonium or substituted ammonium salts and aluminum salts; sulphates, nitrates, phosphates, perchlorates, borates, hydrohalides, acetates, tartrates, maleates, citrates, succinates, palmoates, methanesulphonates, benzoates, salicylates, hydroxynaphthoates, benzenesulfonates, ascorbates, glycerophosphates, or ketoglutarates.

The compounds of the present invention, may have chiral centers and occur as racemates, racemic mixtures and as individual diastereomers, or enantiomers with all isomeric forms being included in the present invention. Therefore, where a compound is chiral, the separate enantiomers, substantially free of the other, are included within the scope of the invention; further included are all mixtures of the two enantiomers. Also included within the scope of the invention are polymorphs as well as hydrates of the compounds of the instant invention.

The present invention includes within its scope prodrugs of the compounds of this invention. In general, such pro drugs will be functional derivatives of the compounds of this invention which are readily convertible in vivo into the required compound. Thus, in the methods of treatment of the present invention, the term"administering"shall encompass the treatment of the various conditions described with the compound specifically disclosed or with a compound which may not be specifically disclosed, but which converts to the specified compound in vivo after administration to the patient.

Conventional procedures for the selection and preparation of suitable prodrug derivatives are described, for example, in"Design of Prodrugs,"ed. H. Bundgaard, Elsevier, 1985.

Metabolites of these compounds include active species produced upon introduction of compounds of this invention into the biological milieu.

Definitions : The terms"individual,""subject,""host,"and"patient"refer to any subject for whom diagnosis, treatment, or therapy is desired. In one embodiment, the individual, subject, host, or patient is a human. Other subjects may include, but are not limited to, animals including but not limited to, cattle, sheep, horses, dogs, cats, guinea pigs, rabbits, rats, primates, opossums and mice. Other subjects include species of bacteria, phages, cell cultures, viruses, plants and other eucaryotes, prokaryotes and unclassified organisms.

The terms"treatment, ""treating,""treat,"and the like are used herein to refer generally to obtaining a desired pharmacological and/or physiological effect. The effect may be prophylactic in terms of completely or partially preventing a disease or symptom thereof and/or may be therapeutic in terms of a partial or complete stabilization or cure for a disease and/or adverse effect attributable to the disease. "Treatment"as used herein covers any treatment of a disease in a subject, particularly a human, and includes: (a) preventing the disease or symptom from occurring in a subject which may be predisposed to the disease or symptom, but has not yet been diagnosed as having it; (b) inhibiting the disease symptom, i. e., arresting its development; or (c) relieving the disease symptom, i. e., causing regression of the disease or symptom.

The term"therapeutically effective amount"shall mean that amount of a drug or pharmaceutical agent that will elicit the biological or medical response of a tissue, system or patient that is being sought by a researcher.

"halo"is iodine, bromine, chlorine or fluorine.

The terms"polycyclic"or"polycyclyl, "as used herein, refer to unsubstituted or substituted fused or bridged polycyclic systems containing from 7 to 20 carbon atoms and which can contain one or more degrees of unsaturation. Preferably, the term"polycyclyl" refers to unsubstituted or substituted fused or bridged bi-or tri-cyclic systems containing from 7-15 carbon atoms and which are saturated or can contain one or six degrees of unsaturation. More preferably, the term"polycyclyl"refers to unsubstituted or substituted fused or bridged bi-or tri-cyclic systems containing from 8-12 carbon atoms and which can contain upto six degrees of unsaturation. Examples of prefered polycyclyl systems include, but are not limited to, naphthalene, tetraline, dihydro naphthalene, decahydronaphthalene, quinoline, tetrahydro quinoline, iso quinoline, tetrahydro isoquinoline, quinazolinone, benzoxazine, dihydrobenzoxazine, benzothiazine, dihydrobenzothiazine, indole, dihydro indole, isoindole, dihydro isoindole, pyrrolo oxazole, pyrrolizidine, benzotriazole, benzoxazole, benzothiazole, imidazopyridazine, pyrazolopyrimidine, pyrazolopyridine, benzimidazole, indazole, furopyridine, benzofuran, benzothiophene, pyrindine, pyrazolodiazepine, benzotriazene, azirinoindole, pyrazoloquinoline, imidazoquinoline, benzothiazene, phthalazene, quinazoline, quinoxaline, benzoxathiin, carbazole, naphthofuran, naphthopyrans, benzothiophene, acridine, benzoisoquinoline, benzoquinoline.

'Alkyl'group is a linear or branched (Ci-Clo) alkyl group. Exemplary alkyl groups include methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, t-butyl, n-pentyl, iso-pentyl, hexyl, heptyl, octyl and the like.

'Alkenyl'is a (C2-Cto) alkenyl group. Exemplary alkenyl groups include ethenyl, propenyl, prop-1-enyl, isopropenyl, butenyl, but-1-enyl, isobutenyl, pentenyl, pent-1-enyl, hexenyl, pent-2-enyl, 2-methyl-but-2-ene, 2-methyl-pent-2-enyl and the like 'Alkynyl'is (C2-Clo) alkynyl. Exemplary alkynyl groups include ethenyl, propynyl, prop-1-ynyl, butynyl, but-ynyl and the like.

"cycloalkyl"is (C3-C8) cycloalkyl group. Exemplary cycloalkyl groups include, but are not limited to cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and the like.

"alkoxy"is (Cl-Clo) alkyl-O-, wherein (Cs-C, o) alkyl group is as defined above.

Exemplary alkoxy groups include but are not limited to methoxy, ethoxy, propyloxy, butyloxy, iso-propyloxy and the like.

"thioalkoxy"is (Cl-ClO) alkyl-S-, wherein (C-Clo) alkyl group is as defined above.

Exemplary alkoxy groups include but are not limited to thiomethoxy, thioethoxy, thiopropyloxy, thiobutyloxy, thioiso-propyloxy and the like.

"hydroxyalkyl"is (C-C, O) alkyl-OH, wherein (Cl-Clo) alkyl group is as defined above. Exemplary hydroxyalkyl groups include but are not limited to hydroxy methyl, hydroxyethyl, hydroxypropyl, hydroxyisopropyl, hydroxybutyl, hydroxyisobutyl, hydroxyter. butyl and the like.

"heterocyclyl"is a non-aromatic saturated monocyclic or multicyclic ring system of about 5 to about 10 carbon atoms, having at least one hetero atom selected from 0, S or N. Exemplary heterocyclyl groups include, but are not limited to aziridinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, thiazolidinyl, 1, 3-dioxolanyl, 1,4- dioxanyl and the like.

'Aryl'is optionally substituted monocylic or polycyclic ring system of about 6 to 14 carbon atoms. Exemplary groups include phenyl, naphthyl and the like.

'Heteroaryl'is an aromatic monocyclic or polycyclic ring system of about 5 to about 10 carbon atoms, having at least one heteroatom selected from 0, S or N.

Exemplary heteroaryl groups include as pyrazinyl, isothiazolyl, oxazolyl, pyrazolyl, pyrrolyl, pyridazinyl, thienopyrimidyl, furanyl, indolyl, isoindolyl, benzo [1, 3] dioxolyl, 1,3-benzoxathiole, quinazolinyl, pyridyl, thiophenyl and the like.

"haloalkoxy"is halo substituted (Ci-Clo) alkyl-O-, wherein (C-Clo) alkyl group is as defined above. Exemplary haloalkoxy groups include but are not limited to trifluoromethoxy, 1,2-dichloroethoxy and the like.

'Haloalkyl'is halo- (Ci-Clo) alkyl, where halo and (Ct-Cto) alkyl are as define above.

Exemplary haloalkyl groups include fluoromethyl, chloromethyl, fluoroethyl, chloroethyl, trilfluoromethyl and the like.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in. the art to which this invention belongs. Although any methods, devices, and materials similar or equivalent to those described herein can be used in the practice or testing of the invention, the preferred methods, devices and materials are now described.

All publications and patents mentioned herein are incorporated herein by reference for the purpose of describing and disclosing, for example, the constructs and methodologies that are described in the publications, which might be used in connection with the presently described invention. The publications discussed above and throughout the text are provided solely for their disclosure prior to the filing date of the present application. Nothing herein is to be construed as an admission that the inventors are not- entitled to antedate such disclosure by virtue of prior invention.

It is to be understood that this invention is not limited to the particular methodology, protocols, cell lines, constructs, and reagents described herein and as such may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims.

The dosage regimen utilizing. the compounds of the present invention is selected in accordance with a variety of factors including type, species, age, weight, sex and medical condition of the patient; the severity of the condition to be treated; the route of administration ; the renal and hepatic function of the patient; and the particular compound or salt thereof employed. An ordinarily skilled physician, veterinarian or clinician can readily determine and prescribe the effective amount of the drug required to prevent, counter or arrest the progress of the condition.

Oral dosages of the present invention, when used for the indicated effects, will range between about 0.01 mg per kg of body weight per day (mg/kg/day) to about 100 mg/kg/day. Advantageously, compounds of the present invention may be administered in a single daily dose, or the total daily dosage may be administered in divided doses of two, three or four times daily. Furthermore, preferred compounds for the present invention can be administered in intranasal form via topical use of suitable intranasal vehicles, or via transdermal routes, using those forms of transdermal skin patches well known to those of ordinary skill in the art. To be administered in the form of a transdermal delivery system, the dosage administration will, of course, be continuous rather than intermittent throughout the dosage regimen.

In the methods of the present invention, the compounds herein described in detail can form the active ingredient, and are typically administered in admixture with suitable pharmaceutical diluents, excipients or carriers (collectively referred to herein as'carrier' materials) suitably selected with respect to the intended form of administration, that is, oral tablets, capsules, elixirs, syrups and the like, and consistent with conventional pharmaceutical practices.

For instance, for oral administration in the form of a-tablet or capsule, the active drug component can be combined with an oral, non-toxic, pharmaceutically acceptable, inert carrier such as lactose, starch, sucrose, glucose, methyl cellulose, magnesium stearate, dicalcium phosphate, calcium sulfate, mannitol, sorbitol and the like; for oral administration in liquid form, the oral drug components can be combined with any oral, non-toxic, pharmaceutically acceptable inert carrier such as ethanol, glycerol, water and the like. Moreover, when desired or necessary, suitable binders, lubricants, disintegrating agents and coloring agents can also be incorporated into the mixture. Suitable binders include starch, gelatin, natural sugars such as glucose or betalactose, corn sweeteners, natural and synthetic gums such as acacia, tragacanth or sodium alginate, carboxymethylcellulose, polyethylene glycol, waxes and the like. Lubricants used in these dosage forms include sodium oleate, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, soaium chloride and the like. Disintegrators include, without limitation, starch, methyl cellulose, agar, bentonite, xanthan gum and the like.

The compounds of the present invention can also be administered in the form of liposome delivery systems, such as small unilamellar vesicles, large unilamellar vesicles and multilamellar vesicles. Liposomes can be formed from a variety of phospholipids, such as cholesterol, stearylamine or phosphatidylcholines.

Compounds of the present invention may also be delivered by the use of monoclonal antibodies as individual carriers to which the compound molecules are coupled. The compounds of the present invention may also be coupled with soluble polYmers as targetable drug carriers. Such polymers can include polyvinylpyrrolidone, pyran copolYmer, polyhydroxypropylmethacrylamide-phenol, polyhydroxy- ethylaspartamide-phenol, or polyethyleneoxide-polylysine substituted with palmitoyl residues. Furthermore, the compounds of the present invention may be coupled to a class of biodegradable polYmers useful in achieving controlled release of a drug, for example, polylactic acid, polyglycolic acid, copolYmers of polyactic and polyglycolic acid, polyepsilon caprolactone, polyhydroxy butyric acid, polyorthoesters, polyacetals, polydihydropyrans, polycyanoacrylates and crosslinked or amphipathic block copolYmers of hydrogels.

The compounds of formula (I) can generally be prepared, for example in the course of a convergent synthesis, by linkage of two or more fragments which can be derived retrosynthetically from the formula (I). in the preparation of compounds of formula (I), it may be generally necessary in the course of synthesis temporarily block functional groups which could lead to undesired reactions or side reactions in a synthetic step by protective group suited to the synthesis problem and known to the person skilled in the art. The method of fragment coupling is not restricted to the following examples, but is generally applicable for synthesis of compounds of formula (I).

The novel compounds of the present invention were prepared according to the procedure of the following schemes and examples, using appropriate materials and are further exemplified by the following specific examples. The most preferred compounds of the invention are any or all of those specifically set forth in these examples. These compounds are not, however, to be construed as forming the only genus that is considered as the invention, and any combination of the compounds or their moities may itself form a genus. The following examples further illustrate details for the preparation of the compounds of the present invention. Those skilled in the art will readily understand that known variations of the conditions and processes of the following preparative procedures can be used to prepare these compounds. All temperatures are degrees Celsius unless otherwise noted.

The following Schemes and Examples describe procedures for making representative compounds of the present invention. Moreover, by utilizing the procedures described in detail, one of ordinary skill in the art can readily prepare additional compounds of the present invention claimed herein.

Route 1: o Reaction of compound of formula (2), where Y'represents (CH2) p, (CH2) rB (CH2) q, L'represents a leaving group selected from halo or mesyloxy and"Ar,"is as defined, with a compound of formula (3), wherein the all the symbols are as defined, to produce a compound of the formula (1), wherein Y represents (CH2) pB (CH2) q, (CH2), B (CH2) pD (CH2) q and all other symbols are as defined above, may be carried out in the presence of a solvent such as diethyl ether, THF, DMF, DMSO, DME, toluene, benzene, acetone, acetonitrile and the like or a mixture thereof. The reaction may be carried out in an inert atmosphere, which may be maintained by using inert gases such as N2, Ar, He and the like. The reaction may be effected in the presence of a base such as K2C03, Na2C03 or NaH or mixtures thereof. The reaction temperature may range from-20 °C-120 °C, preferably at a temperature in the range of 0 °C-120 °C. The duration of the reaction may range from 1 to 48 hours. Phase transfer catalyst such as tetraalkylammonium halides or hydroxides or bisulphates may be employed.

Alternatively, when L'= OH and B = Oxygen, Mitsunobu reaction conditions may be employed to obtain compound of formula (I) The intermediate (2) may be obtained by reacting"Ar"which as defined, with (2a) where Y'represents (CH2) p, (CH2) rB (CH2) q, L'represents a leaving group selected from halo or mesyloxy in the presence of a solvent such as diethyl ether, THF, DMF, DMSO, DME, toluene, benzene, acetone, acetonitrile and the like or a mixture thereof and a base such as KOH, K2C03, Na2C03 or NaH. The reaction may be carried out in an inert atmosphere, which may be maintained by using inert gases such as N2, Ar, He and the like.

Alternatively, the intermediate (2) where Y'is (CH2) TB (CH2) p and Ll represents a leaving group selected from halo or mesyloxy may be obtained by reacting the compound of formula (2b) wherein"Ar"and B have the meaning as described, with (2c) where L'represents a leaving group selected from halo or mesyloxy in the presence of a solvent such as diethyl ether, THF, DMF, DMSO, DME, toluene, benzene, acetone, acetonitrile and the like or a mixture thereof and a base such as K2C03, Na2C03 or NaH.

The reaction may be carried out in an inert atmosphere, which may be maintained by using inert gases such as N2, Ar ; He and the like. The reaction temperature may range from-20 °C-120 °C, preferably at a temperature in the range ofO°C-120 °C. The duration of the reaction may range from 1 to 48 hours. Phase transfer catalyst such as tetraalkylammonium halides or hydroxides or bisulphates may be employed.

Route 2: Reaction of compound of formula (4), where y2 represents (CH2) p l and"Arl"is as defined with a compound of formula (5), where all other symbols are as described, to produce a compound of the formula (I), wherein Y represents (CH2) pB (CH2) q where B represents NH and all other symbols are as defined above, may be carried out in two steps; the first step being the imine formation, followed by reduction. Formation of imine may be carried out in solvents such as benzene, toluene, chloroform, dichloromethane, MeOH, EtOH, i-PrOH and the like. The reaction may be effected in the presence of a catalyst such as pTsOH, NaOAc, BF3. OEt, KOAc and the like or the mixtures thereof. The temperature of reaction may range from room temperature to the reflux temperature of the solvent used. The reaction time may be 2 h to 24 h, preferably in the range 2 h to 12 h.

The imine can also be obtained by the reaction of a compound of general formula (4) with a compound of formula (5) using solvent such as CH2C12, CHC13, chlorobenzene, benzene, THF, in the presence of catalyst such as p-toluenesulfonic acid, methanesulfonic acid, TFA, TfOH, BF3-OEt2 and the like. The reaction may also be carried out in presence of activated molecular sieves. The temperature of the reaction may range from 10 °C to 100 °C, preferably at a temperature in the range from 10 °C to 60 °C. The reaction time may range from 1 h to 48 h.

The imine product thus obtained above may be reduced by using Na (CN) BH3-HCI (ref : Hutchins, R. O. et al. J. Org. Chem. 1983, 48, 3433), NaBH4, H2-Pd]/C, H2-Pt/C, H2- Rh/C and the like in solvents such as methanol, ethanol and the like.

Route 3: (D Reaction of compound of formula (6), wherein all symbols are as defined with a compound of formula (7) Y3 represents (CH2) p, (CH2) pB (CH2) q, L2 represents a leaving group selected from halo or mesyloxy, Ar2 and Z have the meaning as described to produce a compound of the formula (1), wherein Y represents (CH2) pB (CH2) q, (CH2) rB (CH2) pB (CH2) q and all other symbols are as defined above, may be carried out in the presence of aprotic solvents such as diethyl ether, THF, DMF, DMSO, DME, toluene, benzene, acetone, acetonitrile and the like or mixtures thereof. The reaction may be carried out in an inert atmosphere, which may be maintained by using inert gases such as N2, Ar, He and the like. The reaction may be effected in the presence of a base such as K2C03, Na2CO3 or NaH or mixtures thereof. The reaction temperature may range from-20 °C- 120 °C, preferably at a temperature in the range of 0 °C-120 °C. The duration of the reaction may range from 1 to 48 hours. Phase transfer catalyst such as tetraalkylammonium halides or hydroxides or bisulphates may be employed.

Alternatively, when L2 = OH and B = Oxygen, Mitsunobu reaction conditions may be employed to obtain compound of formula (I) The intermediate (6) wherein."Arl"is substituted by mesyloxy may be obtained by mesylating the corresponding hydroxy substituted intermediate (6a) with mesyl chloride in the presence of a base such as trialkylamine, pyridine or K2CO3 and solvent such as chloroform, dichloromethane or THF at a temperature range of-25 ° C to room temperature, preferably 0 °C to room temperature.

Route 4: (I) Reaction of compound of formula (8), wherein "Ar1" has the meaning as described with a compound of formula (9), where Y represents (CH2) p, (CH2) pB (CH2) q, (CH2) rB (CH2) pB (CH2) q, L3 represents a leaving group selected from halo or mesyloxy, and all other symbols have the meaning as described to produce a compound of the formula (I) wherein Y represents (CH2) p, (CH2) pB (CH2) q, (CH2) rB (CH2) pB (CH2) q, and all other symbols are as defined above, may be carried out in the presence of aprotic solvents such as diethyl ether, THF, DMF, DMSO, DME, toluene, benzene, acetone, acetonitrile and the like or mixtures thereof. The reaction may be carried out in an inert atmosphere, which may be maintained by using inert gases such as N2, Ar, He and the like. The reaction may be effected in the presence of a base such as KOH, K2C03, Na2CO3 or NaH or mixtures thereof. The reaction temperature may range from-20 °C-120 °C, preferably at a temperature in the range of 0 °C-120 °C. The duration of the reaction may range from 1 to 48 hours. Phase transfer catalyst such as tetraalkylammonium halides or hydroxides or bisulphates may be employed.

Route 5: (D Reaction of compound of formula (10), where Y4 represents (CH2) p, (CH2) pB (CH2) q, L4 represents a leaving group selected from halo or mesyloxy,"Arl"has the meaning described, with a compound of formula (11), where Y3 represents (CH2) q and all other symbols are as described to produce a compound of the formula (I) wherein Y represents (CH2) pB (CH2) q and all other symbols are as defined above, may be carried out in an inert atmosphere, which may be maintained by using inert gases such as N2, Ar, He and the like. The reaction may be effected in the presence of a base such as NaH and a solvent such as DMF, THF, dioxane, ether or a mixture thereof. The reaction temperature may range from-20 °C-120 °C, preferably at a temperature in the range of 0 °C-120 °C. The duration of the reaction may range from 1 to 48 hours. Phase transfer catalyst such as tetraalkylammonium halides or hydroxides or bisulphates may be employed.

Alternatively, when L4 = OH and B = Oxygen, Mitsunobu reaction conditions may be employed to obtain compound of formula (I) Synthesis of intermediate 11 Reaction of compound of formula (17) wherein Z is protecting groups like benzyl, THP, TBDMS and likes, and all symbols are as defined above, with compound of formula (18) where all symbols are as defined above to produce a compound of formula (11) where all symbols are as defined above may be carried out in the presence of an aprotic solvent such as THF, DMF, DMSO, DME, toluene, benzene, xylene, acetonitrile and the like or mixtures thereof. The reaction may be carried out in the presence of an organic base such as triethylamine, collidine, lutidine and the like or mixtures thereof. The reaction may be carried out in an inert atmosphere that may be maintained by using an inert gas such as nitrogen, helium or argon. The reaction may be effected in the presence of a base such as K2CO3, Na2CO3, NaNH2, n-BuLi, NaH, KH and the like. The reaction temperature may range from 0 to 120 °C, preferably in the range of 25 to 100 °C. The duration of the reaction may range from 1 to 72 h, preferably from 1 to 24 h.

Alternatively, Mitsunobu reaction conditions may be employed to obtain compound of formula (I) Route 6: Reaction of compound of formula (12), where all symbols have the meaning described, with modified Wittig reagent (13), where R7 represents substituted or unsubstituted groups selected from alkyl, cycloalkyl, R5 represents (Cl-s2) alkoxy, R9 represents (Cl-6) alkyl to produce a compound of formula (1) wherein A and R6 together represent a bond, RS represents (C-l2) alkoxy, m and n is 0 and R7 represents substituted or unsubstituted groups selected from (CI-12) alkyl, cycloalkyl, and all other symbols are as defined above, may be carried out in the presence of a base such as alkali metal hydrides like NaH or KH; organolithiums such as CH3Li, BuLi, LDA, TMEDA and the like; alkoxides such as NaOMe, NaOEt, K+BuO'and the like or mixtures thereof. The reaction may be carried out in the presence of solvents such as diethyl ether, THF, dioxane, DMF, DMSO, DME, toluene, benzene and the like or mixtures thereof. HMPA may be used as cosolvent. The reaction temperature may range from-78 ° to 50 °C, preferably at a temperature in the range of-10 °C to 30 °C. The reaction is more effective under anhydrous conditions.

Alternatively, the compound of formula (I) may be prepared by reacting the compound of formula (12) where all symbols are as defined earlier with Wittig reagents such as Hal' Ph3P+CH-(R7) CO2R9 under similar reaction conditions as described above.

Route 7: Reaction of compound of formula (14), where all symbols have the meaning described with compound of formula (15), where R5, R6 and R7 are as described above; to produce a compound of formula (I) wherein A represents oxygen, R5, R6 and R are as described above, may be carried out in the presence of an aprotic solvent such as THF, DMF, DMSO, DME, toluene, benzene, xylene, acetonitrile and the like or mixtures thereof. The reaction may be carried out in the presence of an organic base such as triethylamine, collidine, lutidine and the like or mixtures thereof. The reaction may be carried out in an inert atmosphere that may be maintained by using an inert gas such as nitrogen, helium or argon. The reaction may be effected in the presence of a base such as K2CO3, Na2CO3, NaNH2, n-BuLi, NaH, KH and the like. The reaction temperature may range from 0 to 120 °C, preferably in the range of 25 to 100 °C. The duration of the reaction may range from 1 to 72 h, preferably from 1 to 24 h.

Alternatively, Mitsunobu reaction conditions may be employed to obtain compound of formula (I) Route 8: Reaction of a compound of formula (14), where all symbols have the meaning described with a compound of formula (16), where R5 and R6 are as defined above to produce a compound of formula (I), where A represents oxygen, R5 and R6 are as defined above; m and n is 0 and R7 represents hydrogen, may be carried out in the presence of chloroform-NaOH or chloroform-KOH and a solvent such as THF, dioxane, ethylether, benzene, toluene and the like or a mixture thereof at a temperature range-25 °C to room temperature preferably O° C to room temperature. (ref. JMC, 2000, 43, 4726-4737. Chem Pharm Bull, 2000, 48, 1978-1985) Route 9: The compound of formula (I) where R4 represent alkyl, alkenyl, -S (O) 2-R8 or- C (O) R8 where R8 is alkyl, alkoxy is obtained by reacting a compound of formula (1) where Y represents (CH2) pNR4 (CH2) q and R4 represents hydrogen, by reacting with R8SO2CI, R8C (O) CI or an acid anhydride in the presence of a base selected from trialkylamine, pyridine or K2CO3 and solvent such as chloroform, dichloromethane or THF at a temperature range of-25 ° C to room temperature, preferably 0 °C to room temperature.

Catalytic amounts of DMAP may also be used to accelerate the reaction.

Route 10: o Z--B Y"- (CH2) m AH-f-R5 Rg Zu Base R HB-A- (CH2) m 15 2).-COOR R R (11) Z is protecting groups like benzyl, THP, TBDMS and likes.

Definition and reaction condition is like Route-8 The present invention is further illustrated by the following examples, which are not to be construed in any way as imposing limitations upon the scope thereof, but rather are illustrative only. On the contrary, it is to be clearly understood that resort may be had to various other embodiments, modifications, and equivalents thereof which, after reading the description herein, may suggest themselves to one of ordinary skill in the art without departing from the spirit of the present invention.

The following acronyms, abbreviations, terms and definitions have been used throughout the experimental section. Acronyms or abbreviations: TLC (thin layer chromatography), mL (milli liters), mp (melting point), RT (room temperature, 20-45 °C), aq (aqueous), min (minute), h (hr, hour), atm (atmosphere), conc. (concentrated), MS (mass spectroscopy/spectrometry), NMR (nuclear magnetic resonance). NMR abbreviations: br (broad), apt (apparent), s (singlet), d (doublet), t (triplet), q (quartet), dq (doublet of quartets), dd (doublet of doublets), dt (doublet of triplets), m (multiplet).

Preparation 1 6-methanesulfonyloxynapthyl-2-carboxaldehyde Step 1: Methyl-6-methanesulfonyloxy (3-napthoate To a mixture of methyl 6-hydroxy P-napthoate (5.0 gm, 1.0 eq, 24.75 mmol) and Et3N (8.6 mL, 2.5 eq, 61.88 mmol) in dry DCM (125 mL) stirred at 0 °C, methanesulfonylchloride (2.89 mL, 1.5 eq, 37.12 mmol) was added and stirring was continued for 5 hr. The reaction mixture was diluted with 200 mL of DCM and washed with aqueous citric acid followed by water and brine. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (6 gm, 86 % yield). Mp: 106-108°C 'H NMR (CDCI3, 200 MHz) 8 : 3.23 (s, 3H); 3.99 (s, 3H); 7. 47 (dd, J= 9.4, 2.4 Hz, 1H) ; 7.81 (d, J= 2.4 Hz, 1H) ; 7.89 (d, J=8.8 Hz, 3H) ; 8.02 (d, J=8.8 Hz, 1H) ; 8.13 (dd, J=8. 8Hz, 1. 4 Hz, 1H) ; 8.63 (s, 1H).

Mass m/z (ES): 281. 1 [M+1], 298.1 [M+NH4+], 303.0 [M+Na], 578.3 [M2+NH4+], 583.3 [M2+Na].

Step 2: 6- (Methanesulfonyloxy) napth-2-ylmethyl alcohol A solution of methyl-6-methanesulfonyloxy P-napthoate (6 gm, 1 eq, 21.4 mmol) obtained in stepl of preparation 1, in dry THF (107 mL) was cooled up to-70 °C, and then DIBAL (53 mL, 3 eq, 64.2 mmol) was added drop wise with constant stirring at-70 °C.

After the addition, the reaction mixture was slowly allowed to attain RT (4 hr). Reaction mixture was quenched with Methanol (150 mL), followed by the addition of saturated solution of Na2SO4. Finally reaction mixture was filtered through celite. Filterate was dried (Na2S04), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (2.9 gm, 53 % yield). Mp: 96-98 °C.

'H NMR (CDCl3, 200 MHz) 8 : 3.19 (s, 3H); 4.87 (s, 2H); 7.40 (dd, J= 9.2, 2.4 Hz, 1H) ; 7.54 (d, J= 8.8 Hz, 1H) ; 7.75 (d, J=2 Hz, 1H) ; 7.81-7. 89 (aromatics, 3H) IR (neat) cm-1 : Mass m/z (ES): 270.3 [M+NH4+], 275.3 [M+Na], 522.5 [M2+NH4+].

Step 3: 6- (Methanesulfonyloxy) napthyl-2-carboxaldehyde To a stirred solution of 6-methanesulfonyloxynapth-2-ylmethyl alcohol (2.9 gm, 1 eq, 11.51 mmol) obtained in step 2 of preparation 1 and activated molecular sieves (4A) in dry DCM (60 mL), pyridiniumdichromate (4.75 gm, 1.1 eq, 12.65 mmol) was added at 0 °C. After the addition, the reaction mixture was allowed to stir at RT for 15 hr. Reaction mixture was filtered through celite, filtrate was dried (Na. 2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (1.2 gm, 41% yield). Mp: 90-92 °C.

'H NMR (CDCl3, 200 MHz) 8 : 3.25 (s, 3H); 7.52 (dd, J= 8.8, 2.5 Hz, 1H) ; 7.83 (d, J= 2 Hz, 1H) ; 7.92-8. 10 (aromatics, 3H); 8. 37 (s, 1H) ; 10.17 (s, 1H).

IR (neat) cm-1 : 2932,1681, 1624, and 1469.

Mass m/z (CI): 251 [M + 1].

Preparation 2 6- (Methanesulfonyloxy) napth-2-ylmethyl bromide A mixture of 6-methanesulfonyloxynapth-2-ylmethanol (2 gm, leq, 7.9 mmol) obtained in step 2 of preparation 1, CBr4 (2.88 gm, 1.1 eq, 8.69 mmol) and PPh3 (3.10 gm, 1. 5 eq, 11.85 mmol) in dry THF (40 mL) was stirred at RT for 17 h. Reaction mixture was condensed and diluted with ethyl acetate (100 mL) and washed with water. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (770 mg, 31 % yield). Mpt: 100- 102 °C. in NMR (CDC13, 200 MHz) #: 3.19 (s, 3H); 4.65 (s, 2H); 7.42 (dd, J= 9,2. 4 Hz, 1H) ; 7.57 (dd, J= 8.4, 1.4 Hz, 1H) ; 7.75 (d, J= 2. 2 Hz, 1H); 7.82-7. 90 (aromatics, 3H) IR (neat) cm-1 : 2925,1360, and 1173.

Mass m/z (CI) : 315 [M (Br) + 1], 317 [M(81Br)+1] Preparation 3 1, 2,3, 4-Tetrahydro-6- (methanesulfonyloxy)-napth-2-ylmethyl methanesulfonate Step 1: Ethyl-6-benzyloxy-1, 2,3, 4-tetrahydro-1-oxo-ß-napthoate To a suspension of NaH (816 mg, 60 % in oil, 2 eq, 20. 42 mmol) in 40 mL dry THF, diethylcarbonate (3.7 mL, 3 eq, 30.64 mmol) was added, and the mixture was heated at 60 °C. To that a solution of 6- (benzyloxy) tetralone (2.57 g, 1 eq, 10.21 mmol) in 10 mL THF was added and the heating was continued for another 4 hours. Reaction mixture was condensed and diluted with ethyl acetate (100 mL) and washed with water. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick liquid (2.58 g, 78 % yield). TLC as well as'H-NMR indicates that the compound is a mixture keto/enol tautomers of 70: 30 ratio. For clarification, lH-NMR data is given here for the keto form.

IH NMR (CDC13, 400 MHz) 5 : 1.28 (t, J=7 Hz, 3H); 2.30-3. 10 (m, 4H); 3.54 (dd, J= 10,4. 5 Hz, 1H); 4.23 (q, J= 7 Hz, 2H); 5.11 (s, 2H); 6.77-6. 92 (aromatics, 2H); 7.32-7. 44 (aromatics, 5 H); 8.02 (d, J= 8.6 Hz, 1H).

IR (neat) cm 1 : 2936,1737, 1677, and 1600.

Mass m/z (CI) : 325 [M+1].

Step 2: Ethyl-6-hydroxy-1, 2,3, 4-tetrahydro-$napthoate Ethyl-6-benzyloxy-1, 2,3, 4-tetrahydro-l-oxo-p-napthoate (460 mg, 1.42 mmol) was hydrogenated under H2 (5 psi pressure) at RT for 6-7 h using 10%-Pd/C (285 mg) as catalyst in a combination of solvents EtOH (14 mL) /water (1.4 mL)/conc. HCI (365 pL) to obtain the desired compound as white solid (250 mg, 80 % yield) after usual workup and purification through column chromatography (ethyl acetate/hexane). Mp: 80-82 °C.

'H NMR (CDC13, 400 MHz) 8 : 1.28 (t, J=7.2 Hz, 3H); 1.78-1. 85 (m, 1H) ; 2.15- 2.22 (m, 1H) ; 2. 65-2. 72 (m, 1H) ; 2.78-2. 82 (m, 2H); 2.85-2. 95 (m, 2H); 4.17 (q, J= 7.2 Hz, 2H); 4.64 (s, 2H); 6. 55-6. 62 (aromatics, 2H); 6.95 (d, J= 8 Hz, 1H).

IR (neat) cm-1 : 3397,2934, 1737,1707, and 1611.

Mass m/z (CI): 3221 [M+1].

Step 3: 6-Hydroxy-1, 2,3, 4-tetarhydronapth-2-ylmethyl alcohol A solution of ethyl-6-hydroxy-1, 2,3, 4-tetrahydro-ß-napthoate (480 mg, 1 eq, 2.184 mmol) obtained in step 2 of preparation 3, in dry THF (22 mL) was cooled up to-70 °C, and then DIBAL (10.8 mL, 6eq, 13. 1mmol) was added drop wise with constant stirring at-70 °C. After the addition, the reaction mixture was slowly allowed to attain RT (4 hr). Reaction mixture was quenched with methanol (40mL), followed by the addition of saturated solution of Na2SO4. Finally reaction mixture was filtered through celite. Filtrate was dried (Na2S04), condensed, and the residue, as a crude, was directly used for next reaction.

Step 4: 1,2, 3,4-Tetrahydro-6- (methanesulfonyloxy)-napth-2-ylmethyl methanesulfonate To a stirred solution of 6-Hydroxy-1, 2,3, 4-tetarhydronapth-2-ylmethyl alcohol (280 mg, 1 eq, 1.36 mmol) obtained in step 3 of preparation 3, and Et3N (1. 3 mL, 6 eq, 8.15 mmol) in dry DCM (7 mL) at 0 °C, methanesulfonylchloride (0.316 mL, 3 eq, 4. 07 mmol) was added and stirring was continued for 5 h. The reaction mixture was diluted with 50 mL of DCM and washed with citric acid solution followed by water and brine. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (430 mg, 95 % yield).

'H NMR (CDC13, 400 MHz) 8 : 1.45-1. 55 (m, 1H) ; 1.2. 00-2.06 (m, 1H); 2.20-2. 30 (m, 1H); 2.56 (dd, J= 16,10 Hz, 1H) ; 2.84-3. 03 (m 3H); 3.04 (s, 3H); 3. 13 (s, 3H); 4.18-4. 25 (m, 2H); 7.00-7. 05 (aromatics, 2H); 7.10-7. 13 (aromatics, 1H).

IR (neat) cm-1 : 2937,1352, 1173.

Mass m/z (CI) : 335 [M + 1] Preparation 4 6-benzyloxynapthyl-2-carboxaldehyde Step 1: Methyl-6-benzyloxy-ß-napthoate A mixture of Methyl-6-hydroxy-p-napthoate (6 g, 1 eq, 29. 70 mmol), benzyl bromide (3.9 mL), and anhydrous K2CO3 (8.2 g, 2 eq, 59.41 mmol) in dry DMF was stirred at RT for 16 hr. Reaction mixture was diluted with ethyl acetate (200 mL) and washed with water (3x100 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (8.4 g, 98 % yield). Mp: 149-151 °C.

'H NMR (CDC13, 200 MHz) 8 : 3.97 (s, 3H); 5.21 (s, 2H); 7. 30-7. 48 (aromatics, 7H); 7. 75 (d, J= 8.6 Hz, 1H) ; 7.87 (d, J= 8. 6 Hz, 1H) ; 8.03 (d, J= 8.6 Hz, IH) ; 8.54 (s, 1H).

IR (neat) cm-1 : 3437,2924, 1716, and 1624.

Mass m/z (CI): 293 [M + 1].

Step 2: 6-Benzyloxynapth-2-ylmethyl alcohol A solution of Methyl-6-benzyloxy-ß-napthoate (8 g, 1 eq, 27.39 mmol) obtained) in stepl of preparation 4, in dry THF (200 mL) was cooled up to-70 °C, and then DIBAL (68 mL, 3 eq, 82.19 mmol) was added drop wise with constant stirring at-70 °C. After the addition, the reaction mixture was slowly allowed to attain RT (5 h). Reaction mixture was quenched with Methanol (250 mL), followed by the addition of saturated solution of Na2SO4. Finally reaction mixture was filtered through celite. Filtrate was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (7.1 g, 98 % yield). Mp: 130-132 °C.

'H NMR (CDC13, 200 MHz) 8 : 1.71 (t, J=5.8 Hz, OH); 4.82 (d, J=5.8 Hz, 2H); 5.18 (s, 2H); 7.24 (d, J=7. 4 Hz, 2H); 7.34-7. 51 (aromatics, 6H); 7.71-7. 77 (aromatics, 3H) IR (neat) cm-l : 2924,1694, and 1617.

Mass m/z (CI) : 265 [M + 1], 264 [M], 247 [M-OH].

Step 3 : 6-Benzyloxynapthyl-2-carboxaldehyde To a solution of 6-benzyloxynapth-2-ylmethyl alcohol (7.1 gm, leq, 27.12 mmol) obtained in step 2 of preparation 4 and activated molecular sieves (4 A) in dry DCM (135 mL), PDC (11.2 gm, 1.1 eq, 29.83 mmol) was added at 0 °C. After the addition, the reaction mixture was allowed to stir at RT for 15 hr. Reaction mixture was filtered through celite, filtrate was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (4.15 gm, 59 % yield).

Mp: 102-104 °C.

'H NMR (CDC13, 200 MHz) 8 : 5.18 (s, 2H); 7. 22-7. 47 (aromatics, 7H); 7.73-7. 90 (aromatics, 3H); 8.22 (s, 1H) ; 10.06 (s, 1H).

IR (neat) cm-2 : 2924,1694, 1617.

Mass m/z (CI): 263 [M + 1].

Preparation 5 Methyl 3- (6-bezyloxynapth-2-yl) prop-2-enoate To a stirred solution of 60 % NaH (915 mg, 1.5 eq, 22.90 mmol) in dry THF (60 mL) at 0 °C, trimethylphosphonoacetate (3.7 mL, 1. 5 eq, 22.90 mmol) in dry THF (5 mL) was added drop wise. After the addition reaction mixture was stirred at RT for 1 h. Then again at 0 °C, 6-benzyloxynapthyl-2-carboxaldehyde (4.0 g, 1 eq, 15.27 mmol) obtained in step 3 of preparation 4, in dry THF (10 mL) was added drop wise and after the addition stirring was continued for 16 hr RT. Reaction mixture was concentrated to dryness, diluted with ethyl acetate (200 mL) and washed with water (2x150 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (4.6 g, 95 % yield). Mp: 132-134°C.

'H NMR (CDC13, 200 MHz) 8 : 3.84 (s, 3H) ; 5.21 (s, 2H); 6. 52 (d, J=16 Hz, 1H) ; 7.20-7. 90 (aromatics, 11H).

IR (neat) cm-1 : 2925,1718, and 1620.

Mass m/z (CI) : 319 [M + 1].

Preparation 6 1, 2,3, 4-terahydro-2- (3-Methanesulfonyloxypropyl)-6- (methanesulfonyloxy) naphthalene.

Step 1: Methyl-3- (6-hydroxy-1, 2,3, 4-tetrahydronapth-2-yl) propionate A solution of Methyl 3- (6-bezyloxynapth-2-yl) prop-2-enoate (4.6 g, 1 eq, 14.46 mmol) obtained in preparation 5 and 10 % Pd-C (4.6 g) in ethyl acetate (250 mL) was kept in Parr hydrogenator at 60 psi H2 pressure and at RT for 24 h. Reaction mixture was filtered through celite, dried (Na2S04), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (3.26 g, 90 % yield).

Mass m/z (ES): 252 [M + 18], 257 [M+23].

Step 2: 3- (6-Hydroxy-1, 2,3, 4-tetrahydronapth-2-yl) propan-1-ol A solution of Methyl-3- (6-hydroxy-1, 2,3, 4-tetrahydronapth-2-yl) propionate (3.26 g, 1 eq, 14.17 mmol) obtained in step 1 of preparation 6, in dry THF (140 mL) was cooled up to-70 °C, and then DIBAL (35.1 mL, 3 eq, 42.52 mmol) was added drop wise with constant stirring at-70 °C. After the addition, the reaction mixture was slowly allowed to attain RT (5 h). Reaction mixture was quenched with Methanol (175 mL), followed by the addition of saturated solution of Na2SO4. Finally reaction mixture was filtered through celite. Filtrate was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (800 mg, 28 % yield).

Mass m/z (CI): 207 [M + 1].

Step 3: 1, 2,3, 4-terahydro-2- (3-Methanesulfonyloxypropyl)-6- (methanesulfonyloxy) naphthalene To a stirred solution of 3- (6-Hydroxy-1, 2,3, 4-tetrahydronapth-2-yl) propan-1-ol (720 mg, 1 eq, 1.36 mmol) obtained in step-2 of preparation 6, DMAP (catalytic amount) and Et3N (3.9 mL, 6 eq, 28.41 mmol) in dry DCM (24 mL) at 0 °C, methanesulfonylchloride (1.10 mL, 3 eq, 14.21 mmol) was added and stirring was continued for 5 h. The reaction mixture was diluted with 50 mL of DCM and washed with citric acid solution followed by water and brine. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (800 mg, 47 % yield).

'H NMR (CDC13, 400 MHz) 8 : 1.35-1. 44 (m, 1H); 1.44-1. 55 (m, 2H); 1.65-1. 80 (m, 1H) ; 1.82-1. 90 (m, 2H); 1.90-2. 0 (m, 1H) ; 2.41 (dd, J=16.3, 10.6 Hz, 1H) ; 2.80-2. 90 (m, 2H); 3.02 (s, 3H); 3.12 (s, 3H); 4.26 (t, J=6.8 Hz, 2H); 6.99-7. 02 (aromatics, 2H); 7. 02-7. 10 (aromatics, 1H).

IR (neat) cm-1 : 2939,1605, and 1496.

Mass m/z (CI) : 363 [M + 1].

Preparation 7 3- (5-methanesulfonyloxyindol-1-yl) propyl bromide Stepl : 5- (Methanesulfonyloxy) indole To a stirred solution of 5-hydroxyindole (5 g, 1 eq, 37.59 mmol), DMAP (catalytic amount) and Et3N (10.5 mL, 2 eq, 75.19 mmol) in dry DCM (190 mL) at 0 °C, methanesulfonylchloride (2.92 mL, 1 eq, 37.59 mmol) was added and stirring was continued for 5 hr. The reaction mixture was diluted with 50 mL of DCM and washed with Citric acid solution followed by water and brine. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as brown color solid (5.5 g, 69 % yield). Mp: 94-96 °C.

IH NMR (CDC13, 200 MHz) 8 : 3.11 (s, 3H); 6.55 (s, 1H) ; 7. 09 (dd, J= 8.8 Hz, 2.4 Hz, 1H) ; 7.24-7. 28 (aromatics, 1H) ; 7.36 (d, J=8.8 Hz, 1H) ; 7.54 (s, 1H) ; 8.31 (bs, NH).

IR (neat) cm-1 : 3397, 2924,1479, and 1365.

Mass m/z (CI) : 212 [M+l] Step 2: 3- (5-methanesulfonyloxyindol-1-yl) propyl bromide A mixture of (5-Methanesulfonyloxy) indole (5.5 g, 1 eq, 23.69 mmol) obtained in stepl of preparation 7, and powdered KOH (1.99 g, 1.5 eq, 35.53 mmol) in dry DMSO (120 mL) was stirred at RT for 20 min. To that 1, 3-Dibromopropane (7.2 mL, 3 eq, 71.07 mmol) was added drop wise and the stirring was continued for lh at RT.

Reaction mixture was diluted with ethyl acetate (200 mL) and washed with water (2x100 mL). Organic layer was dried (Na2S04), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (3.3 g, 42 % yield).

'H NMR (CDC13, 200 MHz) 8 : 2.31 (quintet, J=6.2 Hz, 2H); 3.10 (s, 3H); 3.26 (t, J= 6.2 Hz, 2H); 4.31 (t, J=6.2 Hz, 2H); 6.49 (d, J=2.4 Hz, 1H) ; 7.08-7. 37 (aromatics, 3H); 7.50 (d, J=2.2 Hz, IH).

IR (neat) cm-1 : 2932,1481, and 1362.

Mass m/z (CI): 332 [M (79Br) + 1], 334 [M (SlBr) + 1].

Preparation 8 3- (Indol-1-yl) propyl bromide A mixture of indole (3 g, 1 eq, 25.63 mmol) and powdered KOH (2.18 g, 1.5 eq, 38.95 mmol) in dry DMSO (128 mL) was stirred at RT for 20 min. To that 1,3- dibromopropane (7.81 mL, 3 eq, 76.91 mmol) was added drop wise and stirring was continued for 1.5 h at RT. Reaction mixture was diluted with ethyl acetate (150 mL) and washed with water (2x100 mL). Organic layer was dried (Na2S04), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (2.1 g, 35 % yield).

'H NMR (CDC13, 200 MHz) 8 : 2.34 (quintet, J=6.2 Hz, 2H); 3.30 (t, J=6.2 Hz, 2H); 4.33 (t, J= 6.2 Hz, 2H); 6.5 (d, J=2.8 Hz, 1H) ; 7.07-7. 25 (aromatics, 3H); 7.37 (d, J=8 Hz, 1H) ; 7.63 (d, J=8 Hz, 1H).

IR (neat) cm-1 : 2932,1463, and 1314.

Mass m/z (CI): 238 [M (79Br) + 1], 240 [M (8iBr) + 1].

Preparation 9 3- (1, 2,3, 4-terahydroquinolin-1-yl) propyl bromide A mixture of 1,2, 3, 4- tetrahydroquinoline (5 g, 1 eq, 37.59 mmol), 1,3- Dibromopropane (23 mL, 6 eq, 225.56 mmol) and anhydrous Na2CO3 (11.9 g, 3 eq, 112.77 mmol) in dry DMF (375 mL) was stirred at 70 °C for 4 hr. Reaction mixture was diluted with ethyl acetate (200 mL) and washed with water (2x 100 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (3.5 gm, 37 % yield).

'H NMR (CDC13, 200 MHz) 8 : 1.95 (quintet, J=6.2 Hz, 2H) ; 2.15 (quintet, J=6.6 Hz, 2H); 2.75 (t, J= 6.2 Hz, 2H); 3.30 (t, J=5.5 Hz, 2H); 3.39-3. 51 (m, 4H); 6.53- 6.61 (aromatics, 2H); 6.93-7. 08 (m, 2H).

IR (neat) cm'' : 3383 (b), 2930,2842, 1601,1503 Mass m/z (CI) : 254 [M (Br) + 1], 256 [M ($Br) + 1].

Preparation 10 3- (2, 3-dihydroindol-1-yl) propyl bromide A mixture of indoline (3 g, 1 eq, 25.20 mmol), 1, 3-di-bromopropane (15.4 mL, 6 eq, 151.26 mmol) and anhydrous Na2CO3 (8.0 g, 3 eq, 75.63 mmol) in dry DMF (250 mL) was stirred at 70 °C for 4 h. Reaction mixture was diluted with ethyl acetate (200 mL) and washed with water (2x100 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (2.8 g, 47 % yield).

'H NMR (CDC13, 200 MHz) 8 : 2.14 (quintet, J=6.2 Hz, 2H); 2.96 (t, J= 8.1 Hz, 2H); 3.23 (t, J= 6.4 Hz, 2H); 3.34 (t, J=8.1 Hz, 2H); 3.53 (t, J= 6.2 Hz, 2H); 6.51 (d, J=8.1 Hz, 1H) ; 6.65 (t, J=7.2 Hz, 1H) ; 7.03-7. 09 (aromatics, 2H).

IR (neat) cm-1 : 2925,1606, and 1489.

Mass m/z (CI): 240 [M (Br) + 1], 242 [M (8tBr) + 1].

Preparation 11 Ethyl 2-methyl-2- (3-phenoxy) propanoate The title compound was prepared following a literature procedure described in (Ref : JMC, 2001,44, 2061).

'H NMR (CDCl3, 200 MHz) 8 : 1.25 (t, J= 7.1 Hz, 3H); 1. 60 (s, 6H); 4.24 (q, J= 7.1 Hz, 2H); 5.35 (bs, 1H) ; 6.38-6. 49 (aromatics 3H); 7.08 (t, J= 7.8 Hz, 1H) IR (neat) crri : 3418,2989, 2940,1732, 1595,1486.

Mass m/z (CI) : 225 [M+l].

Preparation 12 4- (Methanesulfonyloxy) phenol To a stirred solution of Quinol (5 g, 1 eq, 45.45 mmol), Et3N (12.7 mL, 2 eq, 90.9 mmol) and DMAP (1.1 g, 0.2 eq, 9. 09 mmol) in dry THF (955 mL) at 0 °C, Mesyl chloride (2.6 mL, 0.75 eq, 34.09 mmol) was added drop wise. After the addition, stirring was continued at RT for 3 h. Reaction mixture was concentrated to dryness, diluted with ethyl acetate (400 mL) and washed with 10% citric acid solution (300 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (3 g, 35 % yield). Mp: 82-84 °C 'H NMR (CDC13, 200 MHz) 8 : 3.13 (s, 3H); 5.44 (bs, 1H) ; 6.83 (t, J= 9.1 Hz, 1H) ; 7.15 (t, J= 9. 1 Hz, 1H).

IR (neat) cm-1 : 3455,2989, 2940, 1599, 1505.

Mass m/z (CI): 189 [M+1].

Preparation 13 3- (4-Methanesulfonyloxyphenoxy) propylbromide A mixture of 4-mesyloxy phenol (200 mg, 1 eq, 1.06 mmol) obtained in preparation 12,1, 3-Dibromo propane (0.54 mL, 5 eq, 5.3 mmol) and powdered anhydrous K2C03 (439 mg, 3 eq, 3.18 mmol) in acetone (22 mL) was stirred at 60 °C for 18 h. Reaction mixture was concentrated to dryness, diluted with ethyl acetate (100 mL) and washed with water (2x75 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (200 mg, 61 % yield).

'H NMR (CDC13,200 MHz) 8 : 2.32 (quintet, J= 6.1 Hz, 2H); 3.11 (s, 3H); 3.60 (t, J= 6.3 Hz, 2H); 4.10 (t, J= 5.8 Hz, 2H); 6.91 (t, J= 9.1 Hz, 1H) ; 7.21 (t, J= 9.1 Hz, 1H).

IR (neat) cm-1 : 3026,2929, 1593, 1501.

Mass m/z (CI) : 309 [M (Br) +1], 311 [M (8iBr) +1].

Preparation 14 3- (Methanesulfonyloxy) phenol The title compound was prepared following the typical procedure described for preparation 12.

'H NMR (CDC13, 200 MHz) 8 : 3.15 (s, 3H); 6.79-6. 86 (aromatics, 3H); 7.26 (t, J= 9 Hz, 1H).

IR (neat) cm-1 : 3461,3033, 2939,1603, 1481.

Mass m/z (CI): 189 [M+1].

Preparation 15 3- (3-Methanesulfonyloxyphenoxy) propylbromide The title compound was prepared following the typical procedure described for preparation 13.

'H NMR (CDC, 200 MHz) 8 : 2.32 (quintet, J= 6.3 Hz, 2H) ; 3.14 (s, 3H); 3.60 (t, J= 6.3 Hz, 2H); 4.11 (t, J= 5.8 Hz, 2H); 6.80-6. 90 (aromatics, 3H); 7.25-7. 35 (aromatics, 1H).

IR (neat) cm-1 : 3028, 2938, 1607,1586, 1485.

Mass m/z (CI) : 309 [M (79Br) +1], 311 [M (8'Br) +1].

Preparation 16 Ethyl 2-methyl-2-[4-{3-9methanesulfonyloxy) propyl} phenoxy] propanoate Stepl : 3-(4-hydroxyphenyl) propan-1-ol A suspension of LAH (10.5 g, w/w) in dry THF (500 mL) was refluxed for 3 hr. A solution of ethyl 3- (4-hydroxyphenyl) propionate (10 g, 1 eq, 55. 55 mmol) in dry THF (50 mL) was added drop wise at reflux temperature. After the addition, reaction mixture was refluxed for 6 hr. Reaction mixture was quenched with ethyl acetate (40mL, 4 eq with respect to LAH), followed by the addition of saturated Na2SO4 solution. To the workup mixture conc. HCI was added to adjust the pH at 7.0. Then reaction mixture was filtered through celite and washed with ethyl acetate. Combined filtrate was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as white solid (5.7 g, 68 % yield). Mp: 52-54°C.

'H NMR (CDC, 200 MHz) 8 : 1. 78-1.86 (m, 2H); 2.63 (t, J=7.9 Hz, 2H); 3.67 (t, J= 6. 3 Hz, 2H); 6.74 (d, J= 8.8 Hz, 2H); 7.05 (d, J= 8.8 Hz, 2H).

IR (neat) cm-1 : 3485,3029, 2940, and 1505.

Mass m/z (CI) : 152 [M+1].

Step 2: Ethyl 2-methyl-2- [4- (3-hydroxypropyl) phenoxy] propionate A mixture of 3- (4-hydroxyphenyl) propan-1-ol (3 g, 1 eq, 19.74 mmol), obtained in step 1 of preparation 16, ethyl 2-bromoisobutyrate (8.69 mL, 3 eq, 59.21 mmol), and powdered anhydrous K2CO3 (13.6 g, 5 eq, 98.7 mmol) in EtOH (98 mL) was heated at 70 °C for 17 h. Reaction mixture was condensed to dryness, diluted with ethyl acetate (200 mL) and washed with water (2x100 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (4.7 g, 89 % yield).

'H NMR (CDC13, 200 MHz) 8 : 1.25 (t, J= 7. 2 Hz, 3H) ; 1.57 (s, 6H); 1.82-1. 89 (m, 2H); 2.64 (t, J= 7.2 Hz, 2H) ; 3.65 (. t, J= 6.4 Hz, 2H); 4.23 (q, J= 7.2 Hz, 2H); 6.77 (d, J= 8.8 Hz, 2H); 7.05 (d, J= 8.8 Hz, 2H) IR (neat) cm'' : 3406,2939, 1733, and 1509.

Mass m/z (CI): 267 [M+1].

Step 3: Ethyl 2-methyl-2- [4- (3-methanesulfonyloxypropyl) phenoxy] propionate To a stirred solution of ethyl 2-methyl-2- [4- (3-hydroxypropyl) phenoxy] propionate (4.7 g, 1 eq, 17.66 mmol), obtained in step 2 of preparation 16, DMAP (catalytic amount) and Et3N (4.9 mL, 2 eq, 35.34 mmol) in dry DCM (89 mL) at 0 °C, methanesulfonylchloride (1.37 mL, 1 eq, 17.66 mmol) was added and stirring was continued for 5 h. The reaction mixture was diluted with 50 mL of DCM and washed with citric acid solution followed by water and brine. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (4 g, 66 % yield).

'H NMR (CDC13, 400 MHz) 5 : 1.25 (t, J= 7 Hz, 3H); 1.57 (s, 6H); 2.00-2. 07 (m, 2H); 2.68 (t, J= 7. 2 Hz, 2H); 2.97 (s, 3H); 4.19-4. 26 (m, 4H); 6.78 (d, J= 8.8 Hz, 2H); 7.04 (d, J= 8.8 Hz, 2H) IR (neat) cm'' : 2939,1733, and 1509.

Mass m/z (ES): 345 [M+1], 362 [M+18], 367 [M+23].

Preparation 17 Ethyl 2-methyl-2- [4- (3-iodopropyl) phenoxy] propanoate A mixture of Ethyl 2-methyl-2- [4- (3-methanesulfonyloxypropyl) phenoxy] propionate (500 mg, 1 eq, 1.45 mmol) obtained in preparation 16, and NaI (2.17 g, 10 eq, 14.5 mmol) in dry THF (8 mL) was stirred at 50 °C for 4 h. Reaction mixture was diluted with ethyl acetate (100 mL) and washed with water. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (495 mg, 90 %).

Mass m/z (CI) : 377 (M+1).

Preparation 18 Ethyl 2-methyl-2-13- {3-(methanesulfonyloxypropyl} phenoxy] propanoate Prepared following the same procedure as described in the preparation 16.

'H NMR (CDC13, 200 MHz) #: 1. 25 (t, J= 7.1 Hz, 3H); 1.59 (s, 6H); 2.00-2. 11 (m, 2H); 2.69 (t, J= 7.5 Hz, 2H); 2.99 (s, 3H); 4.17-4. 29 (m, 4H); 6.63-6. 84 (aromatics 3H) ; 7.16 (t, J= 7. 8 Hz, 1H) IR (neat) crri : 2940,1732.

Mass m/z (CI): 345 [M+l].

Preparation 19 ethyl 2-methyl-2- [3- (3-iodopropyl) phenoxy] propanoate Prepared following the same procedure as described in the preparation 17 and using starting material obtained in Preparation 18.

'H NMR (CDC13, 200 MHz) 8: 1.25 (t, J= 7 Hz, 3H); 1.59 (s, 6H); 2.02-2. 16 (m, 2H); 2.66 (t, J= 7.4 Hz, 2H); 3.14 (t, J= 7 Hz, 2H); 4.24 (q, J= 7 Hz, 2H); 6.64-6. 70 (aromatics, 2H); 6.82 (d, J= 7.2 Hz, 1H) ; 7.14 (t, J= 7. 7 Hz, 1H) IR (neat) cm-1 : 3381,2985, 2935,1733, 1584.

Mass m/z (CI): 377 [M+1].

Preparation 20 Ethyl-2-ethoxy-5- (4-aminophenyl) pentanoate Step 1: Ethyl 2-ethoxy-S- (4-nitrophenyl) penta-2,4-dienoate To a stirred solution of NaH (680 mg, 60 % in oil, 1.5 eq, 16.95 mmol) in dry THF (50 mL) at 0 °C, 2-ethoxy triethylphosphonoacetate (4.5 gm, 1.5 eq, 16.95 mmol) in dry THF (5 mL) was added drop wise. After the addition reaction mixture was stirred at RT for 2 h. Then again at 0 °C, 4-Nitrocinnamaldehyde (2.0 g, 1 eq, 11.29 mmol), was added in portion wise and after the addition was over, stirring was continued for 6 h at RT.

Reaction mixture was wuenched with methanol, concentrated to dryness, diluted with ethyl acetate (200 mL) and washed with water (2x150 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as a thick mass as a mixture of 2, 3- E and Z isomers (TLC), 2.6 gi 80 % yield). This was used for step 2 (next reaction).

Step 2: Ethyl-2-ethoxy-5- (4-aminophenyl) pentanoate A solution of Ethyl 2-ethoxy-5- (4-nitrophenyl) penta-2, 4-dienoate (2 g, 1 eq, 6.87 mmol) obtained in step 1 of preparation 20 and 10 % Pd/C (2 g) in ethyl acetate (150 mL) was hydrogenated at 60 psi H2 pressure and at RT for 7 h. Reaction mixture was filtered through celite, dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (1.72 g, 94 % yield).

'H NMR (CDC13, 200 MHz) 8 : 1.22 (t, J=7 Hz, 3H); 1.27 (t, J=7 Hz, 3H); 1. 60- 1. 80 (m, 4H); 2.52 (t, J= 6.8 Hz, 2H); 3.30-3. 50 (m, 1H) ; 3.50-3. 70 (m, RIZ ; 3. 82 (d, J= 5. 3 Hz, IH) ; 4.19 (q, J=7 Hz, 2H) ; 6.62 (d, J=8.3 Hz, 2H); 6.96 (d, J=8.3 Hz, 2H).

IR (neat) cm-l : 3457,2931, 1747,1626, and 1517.

Mass m/z (CI): 265 [M], 266 [M + 1].

Preparation 21 (S)-Ethyl 2-methoxy-3- (4-aminophenyl) propionate Step 1: To a solution of (S)- (4-nitrophenyl) glycine (lOg, 47.6 mmol) in a mixture of water (50 mL), H2SO4 (1M, 60 mL) and acetone (150 mL) at-5 °C, was added under stirring, a solution of sodium nitrite (9.85g, 142.8 mmol) in water (40 mL) drop wise over a period of 30 min. The reaction mixture was stirred at-5 to 0 °C for another 1.5 h, followed by stirring at room temperature for 16 h. Acetone was removed and then the reaction mixture was diluted with 500 mL ethyl acetate. Organic layer was washed with brine, dried over anhydrous Na2SO4, and concentrated. The crude mass was purified by crystallization from isopropyl acetate (9.0 g, 96 %).

Mp: 134-136 °C [aJD :-25° (c 1. 0, MeOH) 'H NMR (CDC13) 5 : 3.04 (dd, J = 14,7. 8 Hz, 1H), 3.24 (dd, J = 14,4, Hz, 1H), 4. 39 (dd, J = 7.3, 4.1 Hz, 1H), 7.42 (d, J = 8.7 Hz, 2H), 8.16 (d, J = 8.7 Hz, 2H).

IR (neat) cm~1 : 3485,3180, 2927,1715, 1515, 1343.

Mass m/z (CI): 212 (M+1).

Step 2 : (S)-2-Hydroxy-3- (4-nitrophenyl) propionic acid (9.0 g, 42.6 mmol), obtained from step (1) above, was dissolved in dry EtOH (300 mL). To this solution was added conc.

H2SO4 (326 pL, 5.9 mmol), and refluxed for 5 to 6 h. The reaction mixture was neutralized with aqueous sodium bicarbonate. Ethanol was condensed on rotavapor, and the residue was dissolved in ethyl acetate. Organic layer was washed with aqueous sodium bicarbonate, water, brine, and then dried over anhydrous Na2SO4, and concentrated.

Desired product was obtained from the crude mass by crystallizing from diisopropylether (8.0 g, 78.5 %)..

Mp: 74-76 °C.

[a] D :-13° (c 1. 0, MeOH) IH NMR (CDC13) 5 : 1. 30 (t, J = 7 Hz, 3H), 3.06 (dd, J = 14,7, Hz, 1H), 3.25 (dd, J = 14,4. 3, Hz, 1H), 4. 25 (q, J = 7 Hz, 2H), 4. 25 (dd, J = 7,4. 3 Hz, 1H), 7.42 (d, J = 8. 7 Hz, 2H), 8. 16 (d, J=8. 7Hz, 2H).

IR (neat) cm-1 : 3432,2924, 1736,1518, 1347.

Mass m/z (CI): 240 (M+1).

Step 3: To a mixture of (5)-Ethyl 2-Hydroxy-3- (4-nitrophenyl) propionate (12.5 g, 52.3 mmol), obtained in step (ii) of above, and powdered Ag2O (36.3 g, 157 mmol) in dry acetonitrile (260 mL) was added methyl iodide (13 mL, 209.2 mmol) at room temperature.

Activated molecular sieves (4 A) (12.5 g) were added and then the reaction mixture was stirred at room temperature for 16 h. The reaction mixture was filtered through celite, and concentrated. The crude mass was chromatographed using ethyl acetate and hexanes to obtain the desired product as viscous liquid (10.0 g, 75%).

[a] D:-30. 1° (c 1. 0, MeOH) 'H NMR (CDC13) 8 : 1.24 (t, J = 7.1 Hz, 3H); 3.09 (d, J = 5.4 Hz, 1H) ; 3.12 (d, J = 2.7 Hz, 1H); 3.35 (s, 3H); 3.96 (dd, J = 7.5, 5. 1 Hz, 1H); 4.19 (q, J = 7.1 Hz, 2H); 7.39 (d, J = 8. 6 Hz, 2H); 8.13 (d, J = 8. 6 Hz, 2H).

IR (neat) cm'' : 2995,1747, 1604,1521, 1343.

Mass m/z (CI) : 254 (M+1).

Step 4: (S)-Ethyl 2-methoxy-3-(4-nitrophenyl) propionate (8.0, 31.6 mmol), obtained in step (3) above, was dissolved in dry methanol (200 mL). To this solution was added 10% Pd/C (2.5 g), and hydrogenated using hydrogen gas (20 psi) for 3-4 h. The reaction mixture was filtered through celite, and concentrated to a syrupy mass. After column chromatography using ethyl acetate/hexanes the desired product was isolated as thick liquid (7.0 g, quantitative).

[a] D :-14. 1° (c 1. 0, MeOH).

Chiral HPLC: >98 % ee.

'H NMR (CDC13) 8 : 1.23 (t, J = 7.2Hz, 3H), 2.91 (d, J = 6. 1Hz, 2H), 3.30 (bs, 2H, NH2), 3.34 (s, 3H), 3.88 (t, J = 6.2Hz, 1H), 4.17 (q, J = 7. 2Hz, 2H), 6.62 (d, J = 8. 3Hz, 2H), 7.01 (d, J = 8. 1Hz, 2H).

IR (neat) cm-1 : 3372,2985, 2932,1739, 1627,1519.

Mass m/z (CI) : 223 (M), 234 (M+1), 192 (M-OMe).

Preparation 22 Ethyl 2-ethoxy-3- (4-aminophenyl) propionate Step 1: Wittig salt from triethyl 2-ethoxyphosphonoacetate (26.5 g, 1.5 eq, 99.3 mmol) and NaH (50% in oil) (5.3 g, 2 eq, 132.4 mmol) was prepared in THF (350 mL) at 0 °C.

To this solid 4-nitrobenzaldehyde (10 g, 1 eq, 66.2 mmol) was added in portions at 0 °C and the resulting solution was stirred at RT for 16 h. The reaction mixture was diluted with ethyl acetate and washed with aqueous NH4CI. The crude contains ethyl p-nitro-2- ethoxycinnamate in both Z and E stereoisomers (11 g).

Step 2: Ethylp-nitro-2-ethoxycinnamate obtained in step (1) was hydrogenated using 10% Pd-C-H2 (60 psi) (11 g) in ethyl acetate (150 mL) at room temperature and chromatographed using ethyl acetate/hexane to yield the title compound as viscous oil (9.41 g, 60%).

'H NMR (CDC13, 200 MHz): S 1.16 (t, J = 7.0 Hz, 3H), 1.22 (t, J = 7.0 Hz, 3H), 2.90 (d, J = 6. 3 Hz, 2H), 3. 30 (bs, 2H, NH2), 3. 35 (m, 1H), 3. 55 (m, 1H), 3.94 (t, J = 6.3 Hz, IH), 4.15 (q, J = 7.0 Hz, 2H), 6.62 (d, J = 8.3 Hz, 2H), 7.03 (d, J = 8. 0Hz, 2H).

IR (neat) cm-1 : 3372,1738.

Mass m/z (CI): 238 (M+1), 192 (M-OC2H5).

Preparation 23 (Methyl 3-ethoxy-4- (4-aminophenyl) butanoate Step 1: (S) -2-ethoxy-3- (4-nitrophenyl) propanoic acid (S)-Ethyl 2-ethoxy-3- (4-nitrophenyl) propanoate (5 g, 1.0 eq, 18.72 mmol), prepared from L-4-nitro phenyl alanine was hydrolyzed by treating with LiOH. H20 (1. 18 g, 1.5 eq, 28.08 mmol) in MeOH-THF-water solvent mixture at RT for 3-4 h. The reaction mixture was condensed, diluted with water and acidified (pH at 3) with aq. HCI. Desired acid was extracted with ethyl acetate (200 mL). Organic layer was dried (Na2SO4), condensed, and the crude (3.66 g, 82 % yield) was directly used for next reaction.

Step 2: (S) -Methyl 3-ethoxy-4- (4-nitrophenyl) butanoate To a stirred solution of (S) -2-ethoxy-3- (4-nitrophenyl) propanoic acid (3.6 g, 1 eq, 15.10 mmol), obtained in step 1 of preparation 23, and Et3N (2.1 mL, 1 eq, 15.10 mmol) in dry DCM (75 mL), isobutyl chloroformate (1.97 mL) was added at 0 °C, and stirring was continued at RT for 1 h. Then at-5 °C, CH2N2 (generated in 40mL of diethyl ether) was added drop wise. After the addition, reaction was continued for 1 h at 0 °C. Reaction mixture was diluted with DCM (50 mL), and washed with water. Organic layer was dried (Na2SO4), condensed, and dried under high vac. The crude mass thus obtained (3.9 g, leq, 14.8 mmol) was dissolved in MeOH (80 mL) and Et3N (6.2 mL, 3 eq, 44.4 mmol) was added. After the addition, Silver acetate (2.5 g, 1 eq, 14.8 mmol) was added at 0 °C in portions and stirring was continued for 1 h. Reaction mixture was condensed to dryness and the crude mass was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass. (2 g, 51 % yield).

'H NMR (CDC13, 400 MHz) 8 : 1.07 (t, J= 6.8 Hz, 3H); 2.42 (dd, J=15. 6,6. 4 Hz, 1H); 2.56 (dd, J=15.6, 7 Hz, 1H); 2.87-2. 98 (m, 2H); 3.33-3. 41 (m, 1H) ; 3.47-3. 55 (m, 1H) ; 3.69 (s, 3H); 3.96 (q, 1H); 7.4 (d, J=8.8 Hz, 2H); 8.15 (d, J=8.8 Hz, 2H).

IR (neat) cm-l : 2976,1738, 1603, and 1520.

Mass m/z (CI) : 268 [M+1] Step 3: (Methyl 3-ethoxy-4- (4-aminophenyl) butanoate A solution of (S) -Methyl 3-ethoxy-4- (4-nitrophenyl) butanoate (2 g, 1 eq, 7.49 mmol) obtained in step 2 of preparation 23 and 10 % Pd/C (500 mg) in ethyl acetate (250 mL) was hydrogenated at 40 psi H2 pressure and at RT for 7 h. Reaction mixture was filtered through celite, dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (1.3 g, 73 % yield).

'H NMR (CDC13,400 MHz) 8 : 1. 13 (t, J=7 Hz, 3H); 2.44 (d, J=6.2 Hz, 2H); 2.62 (dd, J=13.8, 7 Hz, 1H) ; 2.82 (dd, J=13.8, 5.8 Hz, 1H) ; 3.31-3. 55 (m, 2H + NH) ; 3.65 (s, 3H); 3.85-3. 94 (m, 1H); 6.62 (d, J= 7.8 Hz, 2H); 7 (d, J=7. 8 Hz, 2H).

IR (neat) cm l : 3370, 2975, 1736,1626, and 1518.

Mass m/z (CI) : 238 [M+1] Preparation 24 7-Methanesulfonyloxy-3, 4-dihydro-2H-bezo lb] 11, 4l oxazine Step 1: 3-Hydroxy-4-nitrophenol To a stirred solution of powdered KOH (10.6 g, 2 eq, 0.19 mol) in 60 mL of water, 5-flouro-2-nitrophenol (15 g, 1 eq, 0.095 mol) was added portion wise at 20-40 °C and the reaction mixture was heated at 90 °C for 28 h. Then every 4 h interval (3 times), 0. 4 equiv. of powdered KOH was added to the reaction mixture and heating was continued for 15h.

Being guided by TLC (90% completion), reaction was stopped. Reaction mixture was diluted with 150 mL of water, acidified with 4N HCl and extracted with ethyl acetate (200 mL x2). Then organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as yellow solid (9.9 g, 68 % yield).

Mp: 106-108 °C 'H NMR (CDC13,400 MHz) 8: 5.97 (bs, -OH); 6.47 (dd, J=9.2, 2.4 Hz, 1H) ; 6.52 (d, J=2. 4 Hz, 1H) ; 8.04 (d, J= 9.2 Hz, 1H) ; 10.93 (s, -OH) IR (KBr) cm-l : 3362,1622, 1533,1291.

Mass m/z (CI) : 156 [M+1] Step 2 : 5-Methanesulfonyloxy-2-nitrophenol To a stirred solution of 3-hydroxy-4-nitrophenol (1 g, 1 eq, 6.45 mmol), obtained in step 1 of Preparation 24 and Et3N (900 µL, 1 eq, 6.45 mmol) in dry DCM (130 mL) at 0 °C, methanesulfonyl chloride (500 J. L, 1 eq, 6.45 mmol) was added in a 15 min time and stirring was continued for another 15 min. The reaction mixture was diluted with 100 mL of DCM and washed with water (unreacted starting material went in aqueous layer).

Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as yellow solid (570 mg, 38 % yield).

Mp: 123-124 °C 'H NMR (CDC13, 400 MHz) 5 : 3.25 (s, 3H); 6.95 (dd, J= 9.2, 2.8 Hz, 1H) ; 7.11 (d, J= 2.8 Hz, 1H) ; 8.20 (d, J= 9.2 Hz, 1H) ; 10.71 (s, -OH) IR (KBr) cm-1 : 2943,2600, 1696,1669, 1629.

Mass m/z (CI) : 234 [M+l l Step 3: 2- (5-methanesulfonyloxy-2-nitrophenoxy) ethyl bromide A mixture of 5-methanesulfonyloxy-2-nitrophenol (500 mg, 1 eq, 2.14 mmol) obtained in step2 of Preparation 24, K2CO3 (890 mg, 3 eq, 6.43 mmol) and 1,2-di- bromoethane (925 pL, 5 eq, 10.72 mmol) in 21 mL of dry acetone was stirred at 60 °C for 20 h. Being guided by TLC reaction was stopped. Acetone was removed, diluted with ethyl acetate (100 mL x2) and washed with water (100 mL). Organic layer was dried (Na2S04), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as yellow solid (420 mg, 58 % yield).

Mp: 96-98 °C 'H NMR (CDC13, 400 MHz) 8 : 3.24 (s, 3H); 3.68 (t, J= 6.4 Hz, 2H); 4.43 (t, J= 6.4 Hz, 2H); 7.00 (dd, J=8.8, 2 Hz, 1H) ; 7.03 (d, J= 2 Hz, 1H) ; 7.94 (d, J= 8.8 Hz, 1H).

IR (neat) cm-t : 3412,2936, 1613,1585, 1525.

Mass m/z (CI) : 340 [M (79Br) +1], 342 [M (8IBr) +1] Step 4: 2- (5-Methanesulfonyloxy-2-aminophenoxy) ethyl bromide A solution of 2- (5-methanesulfonyloxy-2-nitrophenoxy) ethyl bromide (400 mg, 1 eq, 1.176 mmol) obtained in step 3 of Preparation 24 and 10 % Pd/C (150 mg) in ethyl acetate (23 mL) was hydrogenated at H2 balloon pressure and at 20-40 °C for 4 h.

Reaction mixture was filtered through celite, dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as yellow solid (300 mg, 82 % yield).

Mp: 69-70 °C 'H NMR (CDCl3, 400 MHz) 8 : 3.09 (s, 3H); 3.67 (t, J= 6 Hz, 2H); 4.32 (t, J= 6 Hz, 2H); 6.67-6. 75 (aromatics, 3H) IR (KBr) cm-1 : 3437,3327, 1616,1511, 1345.

Mass m/z (CI) : 310 [M (79Br) +1], 312 [M (8lBr) +1] Step 5: 7-Methanesulfonyloxy-3, 4-dihydro-2H-bezo [bl l1, 4] oxazine A mixture of 2- (5-methanesulfonyloxy-2-aminophenoxy) ethyl bromide (300 mg, 1 eq, 0.97 mmol) obtained in step 4 of Preparation 24 and K2CO3 (400 mg, 3 eq, 2.90 mmol) in 6 mL of dry DMF was stirred at 60 °C for 16 h. Being guided by TLC, reaction was stopped. Reaction mixture was diluted with ethyl acetate (50 mL) and washed with water (50 mL x2). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as pale brown solid (190 mg, 85 % yield).

Mp: 95-97 °C 'H NMR (CDC13, 400 MHz) 8 : 3.08 (s, 3H) ; 3.41 (t, J= 4.4 Hz, 2H); 3.81 (bs, NH); 4.24 (t, J= 4.4 Hz, 2H); 6.55 (d, J= 8 Hz, 1H) ; 6.68-6. 73 (aromatics, 2H) IR (KBr) cm-1 : 3390,2984, 1727,1602, 1511.

Mass m/z (CI): 230 [M +1].

Preparation 25 7-Methanesulfonyloxy-3, 4-dihydro-2H-bezo lbl [1, 41 oxazin-3-one Step 1: Ethyl 2-[2-nitro-5-methanesulfonyloxyphenoxylacetate A mixture of 5-methanesulfonyloxy-2-nitrophenol (2.5 g, 10.73 mmol), obtained in step-2 of preparation 24, ethyl 2-bromoacetate (1.3 mL, 11.8 mmol), and anhydrous powdered K2C03 in dry acetone (54 mL) was stirred at 20-40 °C for 16h. Acetone was removed on rotavapor from the reaction mixture was diluted with ethyl acetate. Organic layer was washed with water, dried (Na2SO4), and condensed. The crude was used for next step.

Mass m/z (CI) : 320 [M+1].

Step 2: 7-Methanesulfonyloxy-3, 4-dihydro-2H-bezo lb] [1, 4] oxazin-3-one Ethyl 2- [2-nitro-5-methanesulfonyloxyphenoxy] acetate (3.7 g, crude), obtained in step 1 of preparation 25, was hydrogenolyzed using 10 % Pd/C in ethyl acetate solvent (200 mL) at 20-40 °C over 10 psi H2 pressure. Product was purified by column chromatography (ethyl acetate/hexanes). Yield : 2.0 g (76 %).

Mp: 201-202 °C.

'H NMR (DMSO-d6, 400 MHz) 8 : 3.34 (s, 3H); 4.61 (s, 2H); 6.90-7. 00 (aromatics, 3H); 10.82 (s, 1H).

IR (KBr) cm-1 : 3440,3087, 1687,1509.

Mass m/z (CI) : 244 [M+l].

Preparation 26 Ethyl 2-methyl-2- [4- (hydroxyl) phenoxy] butanoate The said was prepared by hydrogenation of 2- (4-Benzyloxy-phenoxy)-2-methyl- butyric acid ethyl ester (1.2 gms, 3.7. mmol) in ethyl acetate with 10% Pd/C at RT for 5 hours.

'H NMR (CDC13,200 MHz) 8 : 0.98 (t, J= 7.3 Hz, 3H); 1.28 (t, J=6.94 Hz, 3H); 1.41 (s, 3H); 1.94 (q, J= 7.1 Hz, 2H) ; 4.24 (q, J= 7.1 Hz, 2H); 5.17 (bs, 1H) ; 6.80- 6.66 (m, 4H).

IR (neat) cri 1 : 3425,2980, 2854,1731, 1508.

Mass m/z (CI) : 239 [M +1] Preparation 27 Methyl-2-methyl-2- [4- (3-methanesulfonyloxypropyl) phenoxy] butanoate Step 1: 2-methyl-2- [4- (3-hydroxypropyl) phenoxylbutanoic acid To a stirred solution of 3- (4-hydroxyphenyl) propan-l-ol (9 g, 1 eq, 59.2 mmol) obtained in step 1 of Preparation 16 in 296 mL of dry THF, powdered NaOH (21.6 g, 9 eq, 532.8 mmol) was added and was stirred at 20-40 °C for 10 min. Then methyl ethyl ketone (52 mL, 10 eq, 592 mmol) was added at 20-40 °C and followed by stirring at 0 °C for 30 min. Then CHC13 (19 mL, 4 eq, 236.8 mmol) was added drop wise at 0 °C with vigorous stirring. After the addition of CHC13 reaction temperature was maintained at 0 °C for 2 h after which it was allowed to attain 20-40 ° C while vigorous stirring for 24 h. Being guided by TLC, reaction was stopped. Reaction mixture was acidified with 4N HC1 and extracted with ethyl acetate (200 mL x2) 0rganic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (6.4 g, 43 % yield). In this step compound was bit impure, and was characterized in the next step.

Step 2: Methyl 2-methyl-2-14-(3-hydroxypropyl) phenoxy] butanoate A solution of 2-methyl-2- [4- (3-hydroxypropyl) phenoxy] butanoic acid (2.0 g 1 eq, 7.93 mmol) obtained in step 1 of preparation 27 and conc. H2S04 (86 pL, 0.2 eq, 1.59 mmol) in 40 mL of MeOH was heated at 70 °C (gentle reflux) for 17 h. Being guided by TLC, reaction was stopped. Reaction mixture was neutralized using solid NaHC03 and then MeOH was completely removed. Then it was diluted with ethyl acetate (200 mL) and washed with water (100 mL). Organic layer was dried (Na2SO4), condensed and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (1.5 g, 71 % yield).

'H NMR (CDC13,200 MHz) 6 : 0.97 (t, J= 7.4 Hz, 3H); 1. 48 (s, 3H); 1.78-2. 06 (m, 4H); 2.64 (t, J= 7.7 Hz, 2H); 3.65 (t, J= 6.4 Hz, 2H); 3.77 (s, 3H); 6.76 (d, J= 8.4 Hz, 2H); 7.05 (d, J= 8.4 Hz, 2H).

IR (neat) cm-1 : 3385,2930, 1736,1509.

Mass m/z (CI) : 267 [M +1] Step 3: Methyl 2-methyl-2- [4- (3-methanesulfonyloxypropyl) phenoxy] butanoate To a stirred solution of methyl 2-methyl-2- [4- (3-hydroxypropyl) phenoxy] butanoate (1.5 g, 1 eq, 5.63 mmol), obtained in step 2 of preparation 27, DMAP (138 mg, 0.2 eq, 1.12 mmol) and Et3N (1.95 mL, 2.5 eq, 14.07 mmol) in dry DCM (28 mL) at 0 °C, methanesulfonyl chloride (655 1L, 1.5 eq, 8.44 mmol) was added and stirring was continued for 3 h. The reaction mixture was diluted with 50 mL of DCM and washed with water. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (1.7 g, 88 % yield).

'H NMR (CDC13,400 MHz) 8 : 0. 97 (t, J= 7.4 Hz, 3H) ; 1.48 (s, 3H); 1.90-2. 00 (m, 2H) ; 2.00-2. 08 (m, 2H); 2.68 (t, J= 7.6 Hz, 2H); 2.98 (s, 3H); 3.77 (s, 3H); 4.21 (t, J= 6.4 Hz, 2H); 6.77 (d, J= 8.4 Hz, 2H); 7.04 (d, J= 8.4 Hz, 2H) IR (neat) cm-l : 2945, 1736, 1509.

Mass m/z (CI): 345 [M +1] Preparation 28 <BR> <BR> <BR> <BR> Diastereomers of Nl- [ (cLR)-2-hydroxy-l-phenylethyll- (2R/S)-2- [4- (3-hydroxypropyl) phenoxy]-2-methyl butamide To a stirred solution of 2-methyl-2- [4- (3-hydroxypropyl) phenoxy] butanoic acid (5.8 g, 1 eq, 23.01 mmol) obtained in step 1 of Preparation 27, R- (-)-2-phenyl glycinol (9.5 g, 3 eq, 69.03 mmol) and DMAP (561 mg, 0.2 eq, 4.6 mmol) in 115 mL of dry DCM at 0 °C, EDCI (6.2 g, 1.4 eq, 32.21 mmol) was added portion wise and stirring was continued at 0 °C for 30 min and it was allowed to stir at RT for 17 h. Being guided by TLC, reaction was stopped. Reaction mixture was diluted with 200 mL of CHC13 and washed with 10 % Citric acid solution followed by NaHC03 solution. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using silica gel and ethyl acetate/hexane to obtain the faster moving diastereomer (aR, 25 which was eluted at 55% ethyl acetate/hexane, 2.4 g, thick mass) and the slower moving diastetreomer (aR, 2R which was eluted at 60 % ethyl acetate/hexane, 2.2 g, thick mass). Stereochemistry (2S for faster moving diastereomer and 2R for slower moving diastereomer when used (R)- phenylglycinol) of these diastereomers was tentatively assigned. Total yield: 4.6 g (55 %).

Preparation 29 <BR> <BR> Nl-l (aR)-2-hydroxy-1-phenylethyl]-(2S)-2-14-(3-hydroxypropyl) phenoxyl-2-methyl butamide 'H NMR (CDC13, 400 MHz) 8 : 1.05 (t, J= 7.2 Hz, 3H); 1.38 (s, 3H); 1.80-1. 92 (m, 3H); 1.98-2. 05 (m, 1H) ; 2.66 (t, J= 7.8 Hz, 2H); 3.66 (t, J= 6.4 Hz, 2H); 3.90 (d, J= 5. 2 Hz, 2H); 5.13 (dt, J= 7. 2,5. 2 Hz, 1H) ; 6.84 (d, J= 8. 4 Hz, 2H); 7.07 (d, J= 8. 4 Hz, 2H); 7.25-7. 38 (aromatics, 5H) ; 7.45 (d, J= 7.2 Hz, NH) IR (neat) cm-1 : 3413,2933, 1658,1506.

Mass m/z (CI) : 372 [M +1] [α]D = -32° (c = 1%, MeOH, 25 °C) Preparation 30 <BR> <BR> Nl- [ (aR)-2-Hydroxy-l-phenylethyl]- (2R)-2-14- (3-hydroxypropyl) phenoxy]-2-methyl butamide 'H NMR (CDC13, 400 MHz) 8 : 0.93 (t, J= 7.2 Hz, 3H); 1.43 (s, 3H); 1.70-1. 90 (m, 3H); 1.90-2. 00 (m, 1H); 2.67 (t, J= 7.8 Hz, 2H); 3.67 (t, J= 6.4 Hz, 2H); 3.90 (d, J= 5. 2 Hz, 2H); 5.12 (dt, J=7.2, 5.2 Hz, 1H) ; 6.90 (d, J= 8.4 Hz, 2H); 7.11 (d, J= 8.4 Hz, 2H); 7.27-7. 37 (aromatics, 5H) ; 7.46 (d, J= 7.2 Hz, NH).

IR (neat) cm-1 : 3410,2932, 1656,1507.

Mass m/z (CI) : 372 [M +1] [a] p = + 11. 3 ° (c = 1%, MeOH, 25 °C) Preparation 31 (R)- (+)-Methyl-2-methyl-2- [4- (3-methanesulfonyloxypropyl) phenoxyl butanoate Step 1: (R)-2-Methyl-2- 4- (3-hydroxypropyl) phenoxylbutanoic acid A solution of Nl- [ (oLR)-2-hydroxy-l-phenylethyll- (2R)-2- [4- (3-hydroxypropyl) phenoxy] -2-methyl butamide (1.64 g, 4.31 mmol) obtained in Preparation 30 in 35 mL of 6N HCl and 35 mL of Dioxane (1: 1 mixture) was heated at 100 °C for 6 h. Being guided by TLC, reaction was stopped. Reaction mixture was diluted ethyl acetate (300 mL) and washed with water (200 mL). Organic layer was dried (Na2SO4), condensed and the residue, as a crude, was directly used for next reaction as this compound was pure enough to proceed for the next step. Crude yield (1.0 g, #95%) Step 2: Methyl (R)-2-Methyl-2- [4- (3-hydroxypropyl) phenoxy] butanoate A solution of (R)-2-Methyl-2- [4- (3-hydroxypropyl) phenoxy] butanoic acid (1.0 g crude, 3.97 mmol) obtained in stepl of Preparation 31 and conc. H2SO4 (52 p. L, 0.2 eq, 0.79 mmol) in 24 mL of dry MeOH was heated at 70 °C (gentle reflux) for 17 h. Being guided by TLC, reaction was stopped. Reaction mixture was neutralized using solid NaHCO3 and then MeOH was completely removed. Then it was diluted with ethyl acetate (200 mL) and washed with water (100 mL). Organic layer was dried (Na2S04), condensed and the residue, as a crude, was directly used for next reaction as this compound was pure enough to proceed for the next step. Crude yield (0.95 g, 90%) Step 3: (+) Methyl (R)-2-methyl-2- [4- (3-methanesulfonyloxypropyl) phenoxy] butanoate To a stirred solution of methyl (R)-2-methyl-2- [4- (3-hydroxypropyl) phenoxy] butanoate (950 mg, 1 eq, 3.57 mmol), obtained in step 2 of preparation 31, DMAP (87 mg, 0.2 eq, 0.714 mmol) and Et3N (1.2 mL, 2.5 eq, 8.925 mmol) in dry DCM (18 mL) at 0 °C, methanesulfonyl chloride (415 pL, 1.5 eq, 5.355 mmol) was added and stirring was continued for 3 h. The reaction mixture was diluted with 50 mL of DCM and washed with water. Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (800 mg, 66 % yield).

'H NMR (CDC13,400 MHz) 8 : 0.97 (t, J= 7.4 Hz, 3H); 1.48 (s, 3H); 1.90-2. 00 (m, 2H); 2.00-2. 08 (m, 2H); 2.68 (t, J= 7.6 Hz, 2H); 2.98 (s, 3H); 3.77 (s, 3H); 4.21 (t, J= 6.4 Hz, 2H); 6. 77 (d, J= 8.4 Hz, 2H); 7.04 (d, J= 8.4 Hz, 2H).

IR (neat) cm- : 2945,1736, 1509.

Mass m/z (CI) : 345 [M +1].

[a] = + 18° (c =1,1%, MeOH, 25 °C) Preparation 32 (-) Methyl (S)-2-methyl-2-[4-(3-methanesulfonyloxypropyl) phenoxy]butanoate This compound was prepared using the faster moving diastereomer N1-[(αR)-2-hydroxy- 1-phenylethyl]- (2, 5-2- [4- (3-hydroxypropyl) phenoxy] -2-methylbutamide obtained in Preparation 29 and following the same procedure as described in Preparation 31.

[a] =-18° (c =1.25%, MeOH, 25 °C) Preparation 33 3- [4- (para-toluenesulfonyloxy) phenoxy] propylbromide Step-1: 4- (para-Toluenesulfonyloxy) phenol Obtained following the procedure for preparation 12 using p-toluenesulfonyl chloride instead of methanesulfonyl chloride.

Mp: 94-96 °C.

Mass m/z (CI) : 265 [M+1] Step 2: 3-[4-(para-Toluenesulfonyloxy)phenoxy]propylbromide Obtained following the procedure for preparation 13 and using 4- (para- toluenesulfonyloxy) phenol as substrate.

Mp: 60-62 °C.

IH NMR (CDC13, 200 MHz) 8 : 2.23-2. 35 (m, 2H); 2.44 (s, 3H); 3.57 (t, J=6. 3 Hz, 2H); 4.00 (t, J=5. 8 Hz, 2H); 6.76 (d, J=9. 3 Hz, 2H); 6.87 (d, J=9. 3 Hz, 2H); 7.30 (d, J=8. 2 Hz, 2H); 7.68 (d, J=8. 2 Hz, 2H).

IR (neat) cm-1 : 2926,1597, 1501,1170.

Mass m/z (CI) : 385 [M(79Br)+1], 387 [M (81Br) +1].

Preparation 34 5- (para-toluenesulfonyloxy) indole Title compound was prepared following the procedure for Step-1 of Preparation- 7 and usingpara-toluenesulfonylchloride instead of methanesulfonyl chloride.

'H NMR (CDC13,200 MHz) 8 : 2.44 (s, 3H); 6.77 (s, 1H) ; 6.80 (dd, J=9,3 Hz, lH) ; 7. 10-7. 30 (aromatics, 5H) ; 7.71 (d, J=8. 1 Hz, 2H); 8.26 (bs, 1H).

IR (neat) cm-1 : 3421,2925, 1176.

Mass m/z (CI) : 287 [M+1].

Preparation 35 Ethyl 2-methyl-2- [4- (4-methanesulfonyloxybutyl) phenoxy] propanoate Obtained following the procedure for preparation 16 and starting from methyl 4- (4- hydroxyphenyl) butanoate. Spectral characterization for the intermediates and the title compound are given here.

Step 1 : 4- (4-Hydroxybutyl) phenol Mp: 56-58 °C. lu NMR (CDCI3, 200 MHz) 8 : 1.22-1. 70 (m, 4H); 2.52 (t, J=7 Hz, 2H); 3. 40- 3. 80 (m, 2H and-OH); 6.72 (d, J=8. 3 Hz, 2H); 6.97 (d, J=8. 3 Hz, 2H).

IR (neat) cm-1 : 3361,2937, 2859,1613, 1515,1239.

Mass m/z (ES): 184 [M+NH4+], 189.3 [M+Na+], 350.1 [M2+NH4+], 355 [M2+Na+].

Step 2: Ethyl 2-methyl-[4-(4-hydroxybutyl)phenoxy]propanoate 'H NMR (CDC13, 200 MHz) 8 : 1.25 (t, J=7. 4 Hz, 3H); 1.57 (s, 6H); 1.65-1. 82 (m, 4H); 2.56 (t, J=7. 0 Hz, 2H); 3.64 (t, J=6 Hz, 2H); 4.23 (q, J=7. 4 Hz, 2H); 6.76 (d, J=8. 4 Hz, 2H); 7.00 (d, J=8. 4 Hz, 2H).

IR (neat) cm'' : 3375,2938, 1734,1509, 1142.

Mass m/z (CI): 281 [M+l].

Step 3: Ethyl 2-methyl-2-[4-(4-methanesulfonyloxybutyl)phenoxy] propanoate 'H NMR (CDC13,200 MHz) 8 : 1.25 (t, J=7. 2 Hz, 3H); 1.57 (s, 6H); 1.65-1. 80 (m, 4H); 2.59 (t, J=6. 8 Hz, 2H); 2.97 (s, 3H); 4. 15-4. 30 (m, 4H); 6.76 (d, J=8. 4 Hz, 2H); 7.00 (d, J=8. 4 Hz, 2H).

IR (neat) cm-1 : 2940,1732, 1509,1175.

Mass m/z (CI): 359 [M+l].

Preparation 36 Ethyl 2-methyl-2- [3- (5-methanesulfonyloxypentyl) phenoxy] propanoate Obtained following the procedure for preparation 16 and starting from ethyl 3- (5- hydroxyphenyl) pentanoate.

Spectral characterization for the intermediates and the title compound are given here.

Step 1: 3-(5-Hydroxypentyl)phenol 'H NMR (CDCI3, 400 MHz) 8 : 1.24 (t, J=7. 3 Hz, 3H); 1.30-1. 42 (m, 2H); 1.58 (s, 6H); 1.54-1. 65 (m, 4H + OH); 2.56 (t, J=7. 6 Hz, 2H); 3.62 (t, J=6. 4 Hz, 2H); 4.23 (q, J=7. 3 Hz, 2H); 6.64 (dd, J=8. 2,2. 0 Hz, 1H); 6.68 (t, J=1. 9 Hz, 1H) ; 6.80 (d, J=7. 5 Hz, 1H) ; 7.12 (t, J=7. 8 Hz, 1H).

IR (neat) cm'' : 3048,2934, 1733,1548, 1139.

Mass m/z (ES): 295 [M+1] Step 3: Ethyl 2-methyl-2- [3- (5-methanesulfonyloxypentyl) phenoxy] propanoate 'H NMR (CDC13, 400 MHz) 8 : 1.24 (t, J=7. 1 Hz, 3H); 1. 38-1. 48 (m, 2H); 1.58 (s, 6H); 1.60-1. 70 (m, 2H); 1.70-1. 80 (m, 2H) ; 2.56 (t, J=7. 6 Hz, 2H); 2.98 (s, 3H); 4.18-4. 25 (m, 4H) ; 6.65 (dd, J=8. 0,0. 5 Hz, 1H); 6.68 (t, J=1. 8 Hz, 1H); 6.79 (d, J=7. 5 Hz, 1H) ; 7.12 (t, J=7. 8 Hz, 1H).

IR (neat) cm-1 : 2939,1733, 1502,1176.

Mass m/z (ES): 373 [M+1] Preparation 37 Ethyl 2-[3-(3-methanesulfonyloxypropyl)phenoxy]propanoate The title compound has been synthesized starting from 3- (3-hydroxypropyl) phenol, using ethyl 2-bromopropionate and following the procedure for preparation 16. Spectral data for the intermediates and the title compound are given here.

Step 1: Ethyl 2- [3- (3-hydroxypropyl) phenoxylpropanoate Yield: 84 % OH NMR (CDC13, 400 MHz) 8 : 1.25 (t, J=7. 2 Hz, 3H); 1.61 (d, J=6. 7 Hz, 3H); 1.78-1. 94 (m, 2H) ; 2.67 (t, J=7. 5 Hz, 2H); 3.65 (t, J=6. 3 Hz, 2H); 4.21 (q, J=7. 2 Hz, 2H); 4.73 (q, J=6. 7 Hz, 1H) ; 6.65-9-6. 85 (aromatics, 3H); 7.17 (d, J=7. 8 Hz, 1H).

IR (neat) cm : 3406,2939, 1736.

Mass m/z (CI): 253 [M+1].

Step 2: Ethyl 2- [3- (3-methanesulfonyloxypropyl) phenoxylpropanoate Yield: 85 % 'H NMR (CDC13, 400 MHz) 6 : 1.25 (t, J=7. 2 Hz, 3H) ; 1.61 (d, J=6. 7 Hz, 3H); 2.00-2. 20 (m, 2H); 2.59 (t, J=7. 4 Hz, 2H); 3.00 (s, 3H); 4.15-4. 30 (m, 4H); 4.73 (q, J=6. 7 Hz, 1H) ; 6. 68-9-6. 85 (aromatics, 3H); 7.19 (d, J=7. 8 Hz, 1H).

IR (neat) cm'' : 2939, 1747, 1172.

Mass m/z (CI): 331 [M+1].

Preparation 38 <BR> <BR> 1- [4- (3-Methanesulfonyloxypropyl) phenoxy] cyclohexane-1-carboxylic acid, methyl ester The title compound has been synthesized starting from 4- (3-hydroxypropyl) phenol, using cyclohexanone and following the procedure for Methyl 2-methyl-2- [4- (3- methanesulfonyloxypropyl) phenoxy] butanoate, preparation 27. Spectral data for the intermediates and the title compound are given here.

Step 1: 1- [4- (3-Hydroxypropyl) phenoxyleyclohexane-l-carboxylic acid, methyl ester Yield: 38 % (two step) 'H NMR (CDC13, 400 MHz) 8 : 1.48-1. 72 (m, 6H); 1.82-1. 92 (m, 4H); 2.04-2. 18 (m, 2H); 2.63 (t, J=7. 6 Hz, 2H); 3.65 (bs, -OH); 3.70 (t, J=5. 3 Hz, 2H); 3.75 (s, 3H); 6.73 (d, J--8. 6 Hz, 2H); 7.05 (d, J=8. 6 Hz, 2H).

IR (neat) cm'' : 3383,2938, 2860,1733, 1508,1226, 1063.

Mass m/z (CI): 292 [M], 293 [M+1].

Step 2: 4-(3-Methanesulfonyloxypropyl) phenoxy] cyclohexane-1-carboxylic acid, methyl ester Yield: 79 % 'H NMR (CDC13, 400 MHz) 8 : 1.50-1. 77 (m, 6H); 1.82-1. 92 (m, 2H); 2.00-2. 08 (m, 4H); 2.08-2. 14 (m, 2H); 2.67 (t, J=7. 4 Hz, 2H); 2.98 (s, 3H); 3.76 (s, 3H); 4.21 (t, J=6. 4 Hz, 2H); 6.74 (d, J=8. 6 Hz, 2H); 7.04 (d, J=8. 6 Hz, 2H).

IR (neat) cm-1 : 2937,2859, 1733,1508, 1353,1226, 1174.

Mass m/z (CI) : 388. 3 [M+NH4+], 758.5 [M2+NH41].

Preparation 39 1- [4- (3-Methanesulfonyloxypropyl) phenoxy] cyclopentane-1-carboxylic acid, methyl ester The title compound has been synthesized starting from 4- (3-hydroxypropyl) phenol, using cyclopentanone and following the procedure for methyl 2-methyl-2- [4- (3- methanesulfonyloxypropyl) phenoxy] butanoate, preparation 27. Spectral data for the intermediates and the title compound are given here.

Step 1: 1- [4- (3-Hydroxypropyl) phenoxy] cyclopentane-l-carboxylic acid, methyl ester Yield: 60 % (two step) 'H NMR (CDC13, 400 MHz) # : 1.70-1. 90 (m, 6H) ; 2.10-2. 30 m, 4H); 2.67 (t, J=7.6 Hz, 2H); 3.73 (s, 3H); 3.65 (t, J=6.4) ; 6.66 (d, J=8.6 Hz, 2H); 7.04 (d, J=8.6 Hz, 2H).

IR (neat) cm''-. 3387,2950, 2873, 1734, 1510,1235, 1178.

Mass m/z (CI) : 279 [M+l].

Step 2: 1-[4-(3-Methanesulfonyloxypropyl)phenoxy]cyclopentane-1-carb oxylic acid, methyl ester Yield: 54 % 1H NMR (CDCl3, 400 MHz) 8 : 1.70-1. 86 (m, 4H); 2.00-2. 08 (m, 2H); 2. 12-2. 21 m, 2H); 2. 21-2. 30 (m, 2H); 2,67 (t, J=7. 6 Hz, 2H); 2.98 (s, 3H) ; 3. 73 (s, 3H); 4.21 (t, J=6. 2 Hz, 2H) ; 6. 67 (d, J=8. 6 Hz, 2H); 7.03 (d, J=8. 6 Hz, 2H).

IR (neat) cm'' : 2954,2874, 1735,1510, 1359,1236, 1174.

Mass m/z (CI): 357 [M+1].

Preparation 40 1- [4- (4-Methanesulfonyloxybutyl) phenoxy] cyclopentane-1-carboxylic acid, methyl ester The title compound has been synthesized starting from 4- (4-hydroxybutyl) phenol, using cyclopentanone and following the procedure for methyl 2-methyl-2- [4- (3- methanesulfonyloxypropyl) phenoxy] butanoate, preparation 27. Spectral data for the intermediates and the title compound are given here.

Step 1: 1-[4-(4-Hydroxybutyl)phenoxy]cyclopentane-1-carboxylic acid Yield: 59 % 'H NMR (CDC13, 200 MHz) 8 : 1. 55-1. 70 (m, 4H); 1. 70-1. 90 (m, 4H); 2. 15-2.22 (m, 2H); 2. 22-35 (m, 2H); 2.56 (t, J=7. 3 Hz, 2H); 3. 64 (t, J=6. 2 Hz, 2H); 4. 50 (bs, - OH) ; 6. 73 (d, J=9. 0 Hz, 2H); 7.04 (d, J=9. 0 Hz, 2H).

IR (neat) cm-1 : 3446,2930, 2856,1723, 1508, 1195.

Mass m/z (CI) : 278 [M+], 279 [M+11.

Step 2: 1-[4-(4-Hydroxybutyl)phenoxy]cyclopentane-1-carboxylic acid, methyl ester Yield: 84 % 'H NMR (CDC13, 400 MHz) 8 : 1. 55-1. 70 (m, 4H + OH) ; 1. 70-1. 90 (m, 4H); 2. 12- 2. 30 (m, 4H); 2. 56 (t, J=7.4 Hz, 2H); 3.68 (t, J=6. 2 Hz, 2H); 3. 73 (s, 3H); 6.66 (d, J=8.8 Hz, 2H); 7. 03 (d, J=8. 8 Hz, 2H).

IR (neat) cm'' : 3382,2939, 1734,1610, 1508, 1173.

Mass m/z (ES): 293 [M+l], 310. 1 [M+NH4+], 315 [M+Na+], 602.3 [M2+NH4+], 607.3 [M2+Na+].

Step 3: 1- [4- (4-Methanesulfonyloxybutyl) phenoxy] cyclopentane-1-carboxylic acid, methyl ester Yield: 72 % 'H NMR (CDC13, 400 MHz) 8 : 1. 67-1. 88 (m, 8H) ; 2. 10-2. 20 (m, 2H); 2. 20-2. 30 (m, 2H); 2. 58 (t, J=7.3 Hz, 2H) ; 2. 98 (s, 3H); 3. 73 (s, 3H); 4. 22 (t, J=6.3 Hz, 2H); 6. 66 (d, Y=8. 6 Hz, 2H); 7. 02 (d, J=8. 6 Hz, 2H).

IR (neat) cm-1: 2945,1735, 1608,1509, 1173.

Mass m/z (CI) : 370 [M+].

Preparation 41 1-[4-(3-Iodopropyl)phenoxy]cyclopentane-1-carboxylic acid, methyl ester The title compound was prepared using the procedure used for preparation 17 and using 1- [4- (3-methanesulfonyloxypropyl) phenoxy] cyclopentane-1-carboxylic acid, methyl ester, obtained in preparation 39.

Mass m/z (CI): 389 [M+1].

Example 1 (S)-Ethyl 2-methoxy-3- [4-{6-methanesulfonyloxynapth-2-ylmethylamino} phenyl] propanoate A mixture of 6-methanesulfonyloxynapthyl-2-carboxaldehyde (500 mg, 1 eq, 2 mmol) obtained in preparation 1, S ethyl 2-methoxy-3- (4-aminophenyl) propionate (446 mg, 1 eq, 2 mmol), (obtained in preparation 21), activated molecular sieves (4 A), and p- TsOH (38 mg, 0.1 eq, 0.2 mmol) in dry DCM (5 mL) were stirred at RT for 16 h. The reaction mixture was diluted with ethyl acetate (100 ml), washed with aq. sodium bicarbonate, dried (Na2SO4), condensed (rotavapor), and dried under high vac. The crude mass (825 mg) was dissolved in dry methanol (10 ml) and conc HCl (181 pL) was added at 0 °C, followed by NaB (CN) H3 (172 mg, 1.5 eq, 2.727 mmol) in portions. The reaction mixture was stirred at 0 °C for 3 h, after that it was diluted with ethyl acetate (100 mL).

The organic layer was washed with aq. sodium bicarbonate, dried (Na2SO4), and condensed. The residue was chromatographed using ethyl acetate and hexanes to obtain the title compound as white solid (560 mg, 68 % yield). Mp: 94-96°C.

'H NMR (CDC13, 400 MHz) 8 : 1.21 (t, J=7.0 Hz, 3H); 2.8-2. 9 (m, 2H); 3.18 (s, 3H); 3. (s, 3H); 3.88 (dd, J=7.3, 6 Hz, 1H) ; 4.16 (q, J=7.0 Hz, 2H); 4.49 (s, 2H); 6.58 (d, J=8.3 Hz, 2H); 7.03 (d, J=8. 3 Hz, 2H); 7.39 (dd, J=8.8, 2.4 Hz, 1H); 7.54 (dd, J=8.3, 1.4 Hz, 1H); 7.74 (d, J=2 Hz, 1H); 7.81-7. 85 (aromatics, 3H).

IR (neat) cm-1 : 3 3 80, 2927,1727, 1614, and 1522.

Mass m/z (CI): 458 [M + 1].

The following examples (examples 2-4) were made using the typical procedure described for example 1.

Example 2 Ethyl 2-ethoxy-3- [4-{6-methanesulfonyloxynapth-2-ylmethylamino} phenyl propanoate 'White solid, Mp: 118-120°C, Yield: 520mg, 52%.

'H NMR (CDC13, 200 MHz) S : 1.11-1. 24 (m, 6H); 2.87 (d, J=6.7 Hz, 2H); 3.16 (s, 3H); 3.22-3. 42 (m, 1H) ; 3.48-3. 68 (m, 1H); 3.92 (t, J=6.7 Hz, 1H) ; 4.13 (q, J=7.0 Hz, 2H); 4.47 (s, 2H); 6.56 (d, J=8. 3 Hz, 2H); 7.02 (d, J=8.3 Hz, 2H); 7.37 (dd, J=8.8, 2.4 Hz, 1H); 7.52 (d, J=8.8Hz, 1H) ; 7.72 (d, J=2 Hz, 1H) ; 7.78-7. 84 (aromatics, 3H).

IR (neat) cm-1 : 3381,2928, 1731,1614, and 1522.

Mass m/z (CI) : 471 [M], 472 [M + 1].

Example 3 Ethyl 2-ethoxy-5- [4-{6-methanesulfonyloxynapth-2-ylmethylamino} phenyl pentanoate Yield: 580mg, 72%.

'H NMR (CDC13, 400 MHz) 8 : 1.20 (t, J=7.4 Hz, 3H); 1.26 (t, J=7. 3 Hz, 3H); 1.60-1. 80 (m, 4H); 2.51 (t, J=7.3 Hz, 2H); 3.18 (s, 3H) ; 3.23-3. 40 (m, 1H); 3.58- 3.62 (m, 1H) ; 3. 80 (t, J=6.8 Hz, 1H); 4.15-4. 21 (m, 2H); 4.49 (s, 2H); 6.59 (d, J=8.8 Hz, 2H); 6.97 (d, J=8.8 Hz, 2H); 7.39 (dd, J=8.8, 2.4 Hz, 1H) ; 7.55 (dd, J=8.3, 1.5 Hz, 1H) ; 7.74 (d, J=2.4 Hz, 1H); 7.81-7. 86 (aromatics, 3H).

IR (neat) cm-1 : 3404,2931, 1740, 1614, and 1521.

Mass m/z (CI) : 499 [M], 500 [M + 1].

Example 4 Ethyl 2-methyl-2- [4-{6-methanesulfonyloxynapth-2-ylmethylamino} phenoxy] propanoate White solid, Mp: 116-118°C, Yield: 800 mg, 73 %.

'H NMR (CDC13, 200 MHz) 8 : 1.27 (t, J=7Hz, 3H); 1.50 (s, 6H); 3.18 (s, 3H); 4.00 (bs, NH); 4.22 (q, J=7 Hz, 2H); 4.45 (s, 2H); 6.54 (d, J=8.8 Hz, 2H); 6.77 (d, J=8.8 Hz, 2H); 7.34 (dd, J= 8. 8, 2.4 Hz, 1H) ; 7.54 (d, J=9.6 Hz, 1H) ; 7.74 (d, J=2.4 Hz, 1H); 7.80-7. 87 (aromatics, 3H).

IR (neat) cm-1 : 3409,2987, 2936, 1731, and 1512.

Mass m/z (CI): 458 [M + 1].

Example 5 Ethyl 2-ethoxy-3- [4-{3-(indol-1-yl) propyl amino} phenyl] propanoate A mixture of Ethyl 2-ethoxy-3- (4-aminophenyl) propanoate (450 mg, 1 eq, 1.90 mmol) (obtained in preparation 22), 3-(indol-1-yl) propyl bromide (500 mg, 1.1 eq, 2.10 mmol) obtained in preparation 8, anhydrous K2C03 (786 mg, 3 eq, 5.70 mmol), and TBAB (122 mg, 0.2 eq, 0.38 mmol) in dry toluene (13 mL) was stirred at 90 °C for 5 h.

Reaction mixture was diluted with ethyl acetate (100 mL) and washed with water (2x100 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass (335 mg, 40 % yield).

'H NMR (CDC13, 400 MHz) 8 : 1.16 (t, J=7.3 Hz, 3H); 1.22 (t, J=7 Hz, 3H); 2.13 (quintet, J=6.8 Hz, 2H); 2.89 (d, J=6.3 Hz, 2H); 3.09 (t, J=7 Hz, 2H); 3.30-3. 40 (m, 1H) ; 3. 55-3. 62 (m, 1H) ; 3.94 (t, J= 6.3 Hz, 1H) ; 4.16 (q, J=7 Hz, 2H) ; 4.26 (t, J=6.3, 2H); 6.47 (d, J=8.8 Hz, 2H); 6.49 (dd, J=10,4 Hz, 1H) ; 7.03 (d, J=8.3 Hz, 2H); 7.08-7. 12 (aromatics, 2H); 7.20 (dt, J=8. 3, 1.5 Hz, 1H) ; 7.34 (d, J=8.3 Hz, 1H) ; 7.64 (d, J=7.8 Hz, 1H).

IR (neat) cm'' : 3393,2928, 1739,1616, and 1521.

Mass m/z (CI): 395 [M + 1].

The following examples (examples 6-14) were made using the typical procedure described for example 5.

Example 6 (Methyl 2-methoxy-3-[4-{3-(indol-1-yl)propylamino} phenyl] propanoate Yield: 400mg, 52% 'H NMR (CDC13, 200 MHz) 8 : 2.14 (quintet, J=6.8 Hz, 2H); 2.91 (d, J=5.9 Hz, 2H); 3.09 (t, J=6. 7 Hz, 2H); 3.35 (s, 3H); 3.72 (s, 3H); 3.91 (t, J= 5.9 Hz, 1H) ; 4.27 (t, J=6.7, 2H); 6.45-6. 55 (aromatics, 3H) ; 6.95-7. 40 (aromatics, 6H); 7.65 (d, J=7.8 Hz, 1H).

IR (neat) cm-1 : 3394,2926, 1743,1614, and 1521.

Mass m/z (CI) : 367 [M+l].

Example 7 <BR> <BR> <BR> (S)-Ethyl-2-ethoxy-3- 4- {3- (5-methanesulfonyloxyindol-1-yl) propylamino} phenyl) propanoate Yield: 600mg, 65%.

'H NMR (CDC13, 400 MHz) b : 1.17 (t, J=7 Hz, 3H); 1.23 (t, J=7. 3 Hz, 3H); 2.13 (quintet, J=6.9 Hz, 2H); 2.90 (d, J=6.8 Hz, 2H); 3.08 (t, J=6.8 Hz, 2H); 3.12 (s, 3H); 3.32-3. 40 (m, 1H) ; 3.54-3. 62 (m, 1H); 3.94 (d, J= 6. 8 Hz, 1H) ; 4.16 (q, J=7 Hz, 2H); 4.26 (t, J=7 Hz, 2H) ; 6.47 (d, J=8.8 Hz, 2H) ; 6.52 (d, J=2.5 Hz, 1H) ; 7.03 (d, J=8. 3 Hz, 2H); 7.12 (dd, J=8.8, 2.5 Hz, 1H) ; 7.17 (d, J=3.4 Hz, 1H) ; 7.32 (d, J=8. 8 Hz, 1H) ; 7.53 (d, J=2. 4 Hz, 1H).

IR (neat) cm-1 : 3392,2927, 1740,1616, and 1522.

Mass m/z (CI): 489 [M + 1].

Example 8 S)-Methyl-2-methoxy-3-[4-{3-(5-methanesulfonyloxyindol-1-yl) propylamino} phenyl] propanoate Yield: 675mg, 76%.

'H NMR (CDC13,400 MHz) 8 : 2.13 (quintet, J=6. 9 Hz, 2H); 2.85-2. 94 (m, 2H); 3.08 (t, J=6.8 Hz, 2H); 3.13 (s, 3H); 3.35 (s, 3H); 3.72 (s, 3H); 3.91 (dd, J= 7.4, 5.3 Hz, 1H) ; 4.27 (t, J=6.9 Hz, 2H); 6.49 (d, J=8.8 Hz, 2H); 6.52 (d, J=2.5 Hz, 1H) ; 7.02 (d, J=8.8 Hz, 2H); 7.12 (dd, J=8.8, 2.5 Hz, 1H) ; 7. 18 (d, J=2.4 Hz, 1H) ; 7. 33 (d, J=8.8 Hz, 1H) ; 7.54 (d, J=2 Hz, 1H).

IR (neat) cm-1 : 3404,2929, 1742,1616, and 1521.

Mass m/z (CI) : 461 [M + 1].

Example 9 <BR> <BR> Ethyl 2-methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propylamino} phenoxyl propanoate Yield: 600mg, 54% 'H NMR (CDC13, 400 MHz) 6 : 1.28 (t, J=7.1 Hz, 3H); 1.50 (s, 6H); 2.11 (quintet, J=6.3 Hz, 2H) ; 3.05 (t, J=6.9 Hz, 2H); 3.11 (s, 3H); 4. 20-4. 27 (m, 4H); 6.42 (d, J=8.8 Hz, 2H); 6.51 (d, J=3 Hz, 1H); 6.76 (d, J=8.8 Hz, 2H); 7.10 (dd, J=8.8, 2.5 Hz, 1H) ; 7.17 (d, J=3.4 Hz, 1H) ; 7.31 (d, J=8.8 Hz, 1H) ; 7.53 (d, J=2 Hz, 1H).

IR (neat) cm-1 : 3399,2935, 1730,1611, and 1512.

Mass m/z (CI): 475 [M + 1].

Example 10 <BR> <BR> <BR> (S)-Methyl 3-ethoxy-4- [4- {3- (5-methanesulfonyloxyindol-1-yl) propylamino} phenyl] butanoate Yield: 500mg, 49 % IH NMR (CDC13, 400 MHz) 8 : 1.12 (t, J=7 Hz, 3H) ; 2.13 (quintet, J=6.4 Hz, 2H); 2.42 (d, J=2.4 Hz, 1 H) ; 2.43 (d, J=4.5 Hz, lH) ; 2.62 (dd, J=14, 7 Hz, 1 H) ; 2.80 (dd, J=14,5. 8 Hz, 1H) ; 3.08 (t, J=6.8 Hz, 2H); 3.12 (s, 3H); 3.47-3. 53 (m, 2H); 3.65 (s, 3H); 3.88 (quintet, J=5.8 Hz, 1H) ; 4.27 (t, J=6.7 Hz, 2H); 6.48 (d, J=8.8 Hz, 2H); 6.52 (dd, J=3,0. 7 Hz, 1H) ; 6.99 (d, J=8.8 Hz, 2H); 7.11 (dd, J=8.8, 2.4 Hz, 1H) ; 7.17 (d, J=3.4 Hz, 1H) ; 7.32 (d, J=8.8 Hz, IH) ; 7.53 (d, J=2.1 Hz, 1H).

IR (neat) cm-i : 3406,2929, 1734,1616, 1521.

Mass m/z (CI) : 489 [M + 1].

Example 11 Ethyl 2-ethoxy-3- [4- {3- (2, 3-dihydroindol-1-yl) propylamino} phenyll propanoate Yield: 465mg, 35% IH NMR (CDCI3, 400 MHz) 8 : 1.17 (t, J=7.3 Hz, 3H); 1.22 (t, J=6. 8 Hz, 3H) ; 1.92 (quintet, J=6.8 Hz, 2H); 2.90 (d, J=6.8 Hz, 2H); 2.96 (t, J=6. 9 Hz, 2H); 3.17 (t, J=6.9 Hz, 2H); 3.25 (t, J=6.9 Hz, 2H); 3.30-3. 40 (m, 3H); 3.56-3. 61 (m, 1H) ; 3.80 (bs, 1H) ; 3.94 (t, J= 6.9 Hz, 1H) ; 4.16 (q, J=6.8 Hz, 2H); 6.48 (d, J=7.8 Hz, 1H) ; 6.54 (d, J=8.3 Hz, 2H); 6.56 (t, J=7. 3 Hz, 1H) ; 7.03-7. 09 (aromatics, 4H).

IR (neat) cm-1: 3398,2926, 1742,1610, 1522.

Mass m/z (CI): 397 [M + 1].

Example 12 Ethyl 2-ethoxy-3-[4-{(6-methanesulfonyloxy-1, 2,3, 4-tetrahydronapth-2- yl) methylamino} phenyl] propanoate Yield: 100mg, 20 % 'H NMR (CDC13, 200 MHz) 8 : 1.17 (t, J=7 Hz, 3H); 1.25 (t, J=7.2 Hz, 3H); 1.42- 1.55 (m, 1H); 1.95-2. 00 (m, 2H); 2.51 (dd, J= 16,10 Hz, 1H) ; 2.80-3. 00 (m, 5H) ; 3.12-3. 18 (m, 5H) ; 3.25-3. 42 (m, 1H) ; 3. 48-3.65 (m, 1H) ; 3.94 (t, J=6.6 Hz, 1H) ; 4.16 (q, J=7.2 Hz, 2H); 6.57 (d, J=8.3 Hz, 2H); 7.90-7. 15 (aromatics, 5H).

IR (neat) cm~1 : 2925,1739.

Mass m/z (ES): 476 [M + 1].

Example 13 Ethyl 2-ethoxy-3- [4- {3- (6-methanesulfonyloxy-1, 2,3, 4-tetrahydronapth-2-yl) propylamino} phenyll propanoate Yield: 125mg, 16%.

'H NMR (CDC13, 400 MHz) 8 : 1.17 (t, J=7.1 Hz, 3H); 1.23 (t, J=7Hz, 3H); 1. 20- 1.60 (m, 5H) ; 1.72 (quintet, J=7. 3 Hz, 2H); 1. 90-2.00 (m, 1H) ; 2.40 (dd, J= 16,10 Hz, 1H) ; 2.80-2. 85 (m, 2H) ; 2.90 (d, J=6.7 Hz, 2H); 3.10-3. 14 (m, 5H) ; 3.33-3. 40 (m, 1H) ; 3.55-3. 62 (m, 1H) ; 3. 95 (t, J=6.7 Hz, 1H) ; 4.17 (q, J=7.0 Hz, 2H); 6.55 (d, J=8.3 Hz, 2H); 6.98-7. 09 (aromatics, 5H).

IR (neat) cm 3403,2926, 1741,1616, and 1522.

Mass m/z (CI) : 504 [M + 1].

Example 14 Ethyl 2-ethoxy-3- [4- {3- (1, 2,3, 4-tetrahydroquinolyn-1-yl) propylamino} phenyl propanoate Yield: 455mg, 43%.

'H NMR (CDC13, 400 MHz) 8 : 1.17 (t, J=7 Hz, 3H); 1.22 (t, J=7.2 Hz, 3H); 1.88- 1.97 (m, 4H); 2.75 (t, J=6.6 Hz, 2H); 2.89 (d, J=6.8 Hz, 2H); 2.96 (t, J=6.9 Hz, 2H); 3.18 (t, J=6.9 Hz, 2H); 3.27 (t, J=6.9 Hz, 2H) ; 3.32-3. 39 (m, 3H); 3.55-3. 62 (m, 1H + NH); 3.94 (t, J=6.9 Hz, 1H) ; 4.16 (q, J=7.2 Hz, 2H); 6.52 (d, J=8 Hz, 2H); 6.54-6. 59 (aromatics, 2H); 6.94 (dd, J=7.3, 1. 5. Hz, 1H) ; 7.00-7. 05 (aromatics, 3H).

IR (neat) cm-1 : 3392,2929, 1738,1520.

Mass m/z (CI) : 411 [M + 1].

Example 15 Ethyl 2-methyl-2- [4- {6-methanesulfonyloxynapth-2-ylmethoxy} phenoxy] propanoate A mixture of Ethyl 2-methyl-2- (4-hydroxyphenoxy) propanoate (200 mg, 1 eq, 0.89 mmol), (Re£ 1. Med. Chem. 2001,44, 2061) (0. 350 g) 6- (methanesulfonyloxy) napth- 2-ylmethyl bromide (280mg, leq, 0. 89mmol), obtained in preparation 2, and anhydrous K2C03 (368 mg, 3 eq, 2.67 mmol) in 5 mL dry DMF was stirred at RT for 17 h. Reaction mixture was diluted with ethyl acetate (100 mL), and washed with water (2x100 mL).

Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound.

Yield: 335mg, 82%.

'H NMR (CDC13,400 MHz) 8 : 1.26 (t, J=7.2 Hz, 3H); 1.54 (s, 6H); 3.18 (s, 3H) ; 4. 23 (q, J=7.2 Hz, 2H); 5.17 (s, 2H); 6. 83-6. 89 (aromatics, 4H); 7.41 (dd, J=8.8, 2.4 Hz, 1H) ; 7.58 (dd, J=8.8, 1.6 Hz, 1H); 7.66 (d, J=2.4 Hz, 1H); 7. 85-7. 90 (aromatics, 3H) IR (neat) cm'' : 2986, 2936,1730, and 1503.

Mass m/z (CI) : 459 [M + 1].

Example 16 Ethyl 2-methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyloxy} phenoxy] propanoate.

The compound was made using the typical procedure described for example 15 except that the reaction mixture was heated at 70 °C for 4 h.

Yield: 410 mg, 57%.

'H NMR (CDC13, 400 MHz) b : 1.28 (t, J=7.1 Hz, 3H); 1.54 (s, 6H); 2.24 (quintet, J=6.1 Hz, 2H); 3.10 (s, 3H); 3.80 (t, J=5.7 Hz, 2H); 4.24 (q, J=7.1 Hz, 2H); 4.35 (t, J=6.6 Hz, 2H); 6.48 (d, J=3 Hz, 1H) ; 6.74 (d, J=9.1 Hz, 2H) ; 6.90 (d, J=9.1 Hz, 2H); 7.08 (dd, J=8.8, 2.5 Hz, 1H) ; 7.15 (d, J=3 Hz, 1H) ; 7.33 (d, J=8.8 Hz, 1H) ; 7. 52 (d, J=2. 4 Hz, 1H).

IR (neat) cm-l : 2938,1732, 1609, and 1505.

Example 17 Ethyl 2-methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] propanoate To a stirred solution of 5-methanesulfonyloxyindole (300 mg, 1 eq, 0.87 mmol), obtained in step 1 of preparation 7, and powdered KOH (50 mg, 1 eq, 0.87 mmol) in dry DMSO (4 mL) at RT for 20 min, ethyl 2-methyl-2- [4- (3- methanesulfonyloxypropyl) phenoxy] propionate (219mg, 1.2 eq, 1. 04mmol), obtained in preparation 16, in 1 mL of dry DMSO was added at RT. And the reaction was stirred at RT for 3 h. Reaction mixture was diluted with ethyl acetate (100 mL), and washed with water (2x100 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound.

Yield: 350mg, 87%.

'H NMR (CDC13, 400 MHz) 8: 1.25 (t, J=7. 3 Hz, 3H); 1.57 (s, 6H); 2.14 (quintet, J=7.3 Hz, 2H); 2.56 (t, J=7.3 Hz, 2H); 3.12 (s, 3H); 4.10 (t, J=7 Hz, 2H); 4.24 (q, J=7.3 Hz, 2H); 6.50 (d, J=2.5 Hz, 1H); 6.79 (d, J=8.8 Hz, 2H) ; 7.02 (d, J=8.8 Hz, 2H); 7.11-7. 15 (aromatics, 2H); 7.23 (d, J=8.8 Hz, 1H) ; 7.52 (d, J=3 Hz, 1H).

IR (neat) cm-1 : 2937,1731, 1611, and 1509.

Mass m/z (CI): 460 [M + 1].

Example 18 Ethyl 2-methyl-2- [4- {3- (3, 4-dihydro-2H-bezo [b] [1, 41 Oxazin-4-yl) propyl} phenoxy] propanoate A mixture of 3,4-dihydro-2H-benz [b] [1, 4] oxazine (204 mg, 1 eq, 1.51 mmol), ethyl 2-methyl-2- [4- (3-iodopropyl) phenoxy] propanoate (570 mg, 1 eq, 1.51 mmol), obtained in preparation 18, and anhydrous K2CO3 (625 mg, 3 eq, 4.53 mmol) in dry DMF (8 mL) was stirred at 70 °C for 17 h. Reaction mixture was diluted with ethyl acetate (100 mL), and washed with water (2x100 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound.

Yield: 170 mg, 30 %.

Mass m/z (CI): 484 [M + 1].

The following examples (examples 19-22) were made following the typical procedure of example 18.

Example 19 Ethyl 2-methyl-2- [4- {3- (3-methanesulfonyloxyphenoxy) propyl} phenoxy] propanoate Yield: 500mg, 66 %.

IH NMR (CDC13,400 MHz) 8 : 1.25 (t, J=7 Hz, 3H); 1.57 (s, 6H) ; 2.04-2. 08 (m, 2H); 2.73 (t, J=7. 3 Hz, 2H) ; 3.13 (s, 3H); 3.94 (t, J=6.1 Hz, 2H); 4.23 (q, J= 7 Hz, 2H) ; 6.78 (d, J=8.8 Hz, 2H); 6.80-6. 87 (aromatics, 3H); 7.06 (d, J=8.8 Hz, 2H); 7.28 (dd, J=8.6, 8.0 Hz, 1H).

IR (neat) cm-1 : 2939,1732, 1608,1508.

Mass m/z (ES): 437 [M+1], 454 [M+18], 459 [M + 23].

Example 20 Ethyl 2-methyl-2-[3-{3-(4-methanesulfonyloxyphenoxy)propyl}phenoxy ]propanoate Yield: 400 mg, 73 %.

'H NMR (CDC13, 400 MHz) 8 : 1.24 (t, J=7.2 Hz, 3H); 1. 58 (s, 6H); 2.04-2. 10 (m, 2H); 2.74 (t, J=7.1 Hz, 2H); 3.10 (s, 3H); 3.93 (t, J=6.2 Hz, 2H); 4.22 (q, J= 7. 2 Hz, 2H); 6.66 (dd, J=8.1, 2.4 Hz, 1H); 6.73 (d, J=2.0 Hz, 1H) ; 6.83 (d, J=7.5 Hz, 1H) ; 6.88 (d, J=9.1 Hz, 2H); 7.14 (t, J= 7.8 Hz, 1H); 7.18 (d, J=9.1 Hz, 2H).

IR (neat) cm-1 : 2928, 1732, 1608, 1502.

Mass m/z (CI): 437 [M+1].

Example 21 Ethyl 2-methyl-2-[4-{3-(4- Methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoate Yield: 218mg, 41 %.

'H NMR (CDCl3, 200 MHz) 8 : 1.27 (t, J=7 Hz, 3H); 1.53 (s, 6H); 2.23 (quintet, J=6 Hz, 2H); 3.10 (s, 3H); 4.06-4. 17 (m, 4H); 4.24 (q, J= 7 Hz, 2H); 6.74-6. 94 (aromatics, 6H); 7.19 (d, J=9 Hz, 2H).

IR (neat) cm-1 : 2934,1729, 1593,1501.

Mass m/z (CI): 453 [M+1].

Example 22 Ethyl 2-methyl-2-[3-{3-(3- methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoate Yield: 500 mg, 68 %.

'H NMR (CDC13, 400 MHz) 5 : 1.24 (t, J=7.2 Hz, 3H); 1.59 (s, 6H); 2.24 (quintet, J=6.2 Hz, 2H) ; 3.12 (s, 3H); 4.10 (t, J=6 Hz, 2H); 4.14 (t, J=6.1 Hz, 2H); 4.22 (q, J= 7.2 Hz, 2H); 6.39-6. 56 (aromatics, 3H); 6.83-6. 88 (aromatics, 3H); 7.11 (t, J=8 Hz, 1H) ; 7.29 (t, J=8.2 Hz, 1H).

IR (neat) cm-1 : 2936,1732, 1603,1486.

Mass m/z (CI) : 453 [M+1].

Example 23 <BR> <BR> <BR> (S)-2-Methoxy-3- [4-{6-methanesulfonyloxynapth-2-ylmethylamino} phenyl] propanoic acid Ethyl 2-methoxy-3- [4- {3- (4-methanesulfonyloxyphenyl) propylamino} phenyl] propanoate (400 mg, 1.0 eq, 0.875 mmol), obtained in example 1, was hydrolyzed by treating with LiOH. H20 (55.1 mg, 1.5 eq, 1.31 mmol) in MeOH-THF-water solvent mixture at RT for 3-4 h. The reaction mixture was condensed, diluted with water and acidified (pH at 3-4) with aq. HCI. Desired acid was extracted from aqueous layer, dried (NazSO4), condensed, which was then chromatographed using MeOH and CHC13 as eluents to obtain the pure acid as thick mass (150 mg, 40 % yield).

'H NMR (CDC13, 400 MHz) 5 : 2.92 (dd, J=14. 2,7. 4 Hz, 1H) ; 3. 05 (dd, J=14. 2,4. 4 Hz, 1H) ; 3.18 (s, 3H); 3.40 (s, 3H); 3.97 (dd, J=7.4, 4.4 Hz, 1H) ; 4.49 (s, 2H); 6.62 (d, J=8.3 Hz, 2H); 7.04 (d, J=8.3 Hz, 2H); 7.39 (dd, J=8.8, 2.4 Hz, 1H); 7.55 (dd, J=8.3, 1.4 Hz, 1H) ; 7.74 (d, J=2 Hz, 1H); 7.80-7. 85 (aromatics, 3H).

IR (neat) cm-1 : 3436,2927, 1730,1616, and 1519.

Mass m/z (ES): 430 [M + 1], 452 [M + 23]..

The following examples (examples 24-44) were made using the typical procedure described for example 23.

Example 24 2-Ethoxy-3- [4- {6-methanesulfonyloxynapth-2-ylmethylamino} phenyl] propanoic acid Mp: 168-170 °C. Yield: 120 mg, 42 %.

'H NMR (CDC13, 200 MHz) 8: 1.15 (t, J=7 Hz, 3H); 2.87 (dd, J=14.1, 7. 8 Hz, 1H) ; 2.96 (dd, J=14.1, 4.3 Hz, 1H); 3.16 (s, 3H); 3.22-3. 42 (m, 1H) ; 3.48-3. 68 (m, 1H) ; 3.93 (dd, J=7.8, 4.3 Hz, 1H); 4.50 (s, 2H) ; 6.59 (d, J=8.3 Hz, 2H); 7.07 (d, J=8.3 Hz, 2H); 7.37 (dd, J=8.8, 2.7 Hz, 1H) ; 7.57 (dd, J=8.8, 1.6 Hz, 1H) ; 7.75 (d, J=2.7 Hz, 1H) ; 7.82-7. 87 (aromatics, 3H).

IR (neat) cm-1 : 34241,2924, and 1516.

Mass m/z (CI): 444 [M+1], 466 [M + 23].

Example 25 <BR> <BR> <BR> <BR> <BR> 2-Ethoxy-5- [4- {6-methanesulfonyloxynapth-2-ylmethylamino} phenyl] pentatonic acid Yield: 180 mg, 64 %.

IH NMR (CDCI3, 400 MHz) 8 : 1.23 (t, J=7.3 Hz, 3H); 1.62-1. 82 (m, 4H); 2.52 (t, J=7.3 Hz, 2H); 3.18 (s, 3H); 3.47-3. 55 (m, 1H) ; 3.58-3. 64 (m, 1H) ; 3.88 (t, J=5.4 Hz, 1H) ; 4.48 (s, 2H); 6.59 (d, J=8.8 Hz, 2H); 6.97 (d, J=8.8 Hz, 2H); 7.38 (dd, J=8. 8,2. 4 Hz, 1H) ; 7.55 (d, J=9.7 Hz, 1H) ; 7. 74 (d, J=1. 9 Hz, 1H) ; 7. 81-7. 86 (aromatics, 3H).

IR (neat) am-' : 3409,2926, 1724,1613, and 1520.

Mass m/z (CI): 472 [M+1], 494 [M + 23], 943 [M2+1] Example 26 2-Methyl-2- [4- {6-methanesulfonyloxynapth-2-ylmethylamino} phenoxy] propanoic acid Mp: 182-184 °C. Yield: 220 mg, 47 %.

'H NMR (CDC13,400 MHz) 8 : 1.44 (s, 6H); 3.26 (s, 3H); 4.44 (s, 2H); 6.52 (d, J=8.8 Hz, 2H); 6.74 (d, J=8.8 Hz, 2H); 7.40 (dd, J= 8.8, 2.4 Hz, 1H) ; 7.58 (dd, J=8.8, 1.2 Hz, 1H) ; 7.76 (s, 1H) ; 7.83-7. 88 (aromatics, 3H).

IR (KBr) cm-1 : 3428,2924, 2854,1714, and 1515.

Mass m/z (ES): 430.1 [M + 1], 452.1 [M+Na], 859.5 [M2+1].

Example 27 2-Ethoxy-3- [4- {3- (indol-1-yl) propyl amino} phenyl] propanoic acid Yield: 180 mg, 71 %.

'H NMR (CDC13,400 MHz) 8 : 1.18 (t, J=7.0 Hz, 3H); 2.14 (quintet, J=6.8 Hz, 2H); 2.89 (dd, J=14.1, 7.7 Hz, 1H) ; 3.03 (dd, J=14.1, 4.4 Hz, 1H); 3.08 (t, J=7 Hz, 2H); 3.44-3. 50 (m, 1H) ; 3.55-3. 60 (m, 1H) ; 4.03 (dd, J= 7.4, 4.4Hz, 1H) ; 4.27 (t, J=6.9, 2H); 6.48 (d, J=8.8 Hz, 2H); 6.50 (dd, J=10, 4 Hz, 1H) ; 7.03 (d, J=8.3 Hz, 2H); 7.08-7. 12 (aromatics, 2H); 7.20 (dt, J=8.3, 1.5 Hz, 1H); 7.34 (d, J=8.3 Hz, 1H); 7.64 (d, J=7. 8 Hz, 1H).

IR (neat) cm'' : 3391, 2925,1726, 1613, and 1519.

Mass m/z (CI): 367 {M + 1].

Example 28 (S) -2-Methoxy-3- [4- {3- (indol-1-yl) propyl amino} phenyl] propanoic acid Yield: 190 mg, 58 %.

'H NMR (CDC13,400 MHz) 8 : 2.14 (quintet, J=6. 8 Hz, 2H); 2.92 (dd, J=14. 1,7. 3 Hz, 1H) ; 3.04 (dd, J=14.1, 4.4 Hz, IH) ; 3.09 (t, J=6.9 Hz, 2H); 3.39 (s, 3H); 3.96 (dd, J= 7.3, 4.4 Hz, 1H) ; 4.26 (t, J=6 : 8, 2H); 6.46-6. 52 (aromatics, 3H); 7.05 (d, J=8.3 Hz, 2H); 7.08-7. 13 (aromatics, 2H) ; 7.21 (dt, J=8.3, 1.5 Hz, 1H) ; 7.35 (d, J=8.3 Hz, 1H) ; 7.64 (d, J=7.8 Hz, 1H).

IR (neat) cm-1 : 3400,2929, 1727,1614, 1517.

Mass m/z (ES): 353 [M + 1], 375 [M+23].

Example 29 <BR> <BR> <BR> (S)-2-Ethoxy-3- [4- {3- (5-methanesulfonyloxyindol-1-yl) propylamino} phenyl] propanoic acid Yield: 400 mg, 71 %.

1H NMR (CDC13, 400 MHz) 8 : 1. 19 (t, J=7 Hz, 3H) ; 2.13 (quintet, J=6. 9 Hz, 2H) ; 2.90 (dd, J=14.1, 7.3 Hz, 1H) ; 2.97 (dd, J=14.1, 4.4 Hz, 1H) ; 3.08 (t, J=6. 8 Hz, 2H); 3. 12 (s, 3H); 3.44-3. 62 (m, 2H); 4.04 (dd, J= 7.3, 4.4 Hz, 1H) ; 4.26 (t, J=7 Hz, 2H); 6. 47 (d, J=8. 8 Hz, 2H); 6.52 (d, J=2. 5 Hz, 1H) ; 7.03 (d, J=8.3 Hz, 2H); 7. 12 (dd, J=8. 8,2. 5 Hz, 1H) ; 7.17 (d, J=3.4 Hz, 1H) ; 7.31 (d, J=8.8 Hz, 1H) ; 7.53 (d, J=2.4 Hz, 1H).

IR (neat) cm-1 : 3400,2930, 1729,1615, and 1520.

Mass m/z (ES): 461 [M + 1], 483 [M+23]. <BR> <BR> <BR> <BR> <BR> <P> Example 30<BR> <BR> <BR> <BR> (S)-2-Methoxy-3- [4- {3- (5-methanesulfonyloxyindol-1-yl) propylamino} phenyt] propanoic acid Yield: 420 mg, 65 %.

'H NMR (CDC13, 400 MHz) 8 : 2.11 (quintet, J=6.9 Hz, 2H); 2.91 (dd, J=14. 2,6. 8 Hz, 1H) ; 3.02 (dd, J=14.2, 4.4 Hz, 1H) ; 3.07 (t, J=6.8 Hz, 2H); 3.11 (s, 3H); 3.39 (s, 3H); 3.95 (dd, J= 6. 8, 4. 4 Hz, 1H) ; 4.25 (t, J=6.9 Hz, 2H); 6.47 (d, J=8.8 Hz, 2H); 6.51 (d, J=2.5 Hz, lH) ; 7.02 (d, J=8.8 Hz, 2H); 7.10 (dd, J=8.8, 2.5 Hz, IH) ; 7.16 (d, J=2.4 Hz, 1H) ; 7. 30 (d, J=8.8 Hz, 1H) ; 7. 52 (d, J=2. 4 Hz, 1H).

IR (neat) cm-1 : 3381,2930, 1732,1614, and 1521.

Example 31 2-Methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propylamino} phenoxy] propanoic acid Mp: 164-166 °C. Yield: 300 mg, 58 %.

'H NMR (CDC13 + DMSO-d6,400 MHz) 6 : 1.43 (s, 6H); 2.09 (quintet, J=6.7 Hz, 2H); 2.99 (t, J=6. 8 Hz, 2H); 3.19 (s, 3H); 4. 30 (t, J=6.9 Hz, 2H); 6.44 (d, J=8.8 Hz, 2H); 6.48 (d, J=3. 2 Hz, 1H); 6. 73 (d, J=8.8 Hz, 2H); 7.07 (dd, J=8.8, 2.7 Hz, 1H) ; 7.33 (d, J=3.2 Hz, 1H) ; 7.43 (d, J=8.8 Hz, 1H) ; 7.49 (d, J=2.5 Hz, 1H).

IR (neat) cm-1 : 3400,2932, 1590,1611, and 1510.

Mass m/z (ES): 447 [M + 1], 469 [M + 23], 893 [M2 + 1].

Example 32 <BR> <BR> <BR> (S)-3-Ethoxy-4- [4- {3- (5-methanesulfonyloxyindol-1-yl) propylamino} phenyl] butanoic acid Yield: 300 mg, 61 %.

'H NMR (CDC, 400 MHz) 8 : 1.18 (t, J=7 Hz, 3H) ; 2.13 (quintet, J=6.4 Hz, 2H); 2.45-2. 49 (m, 2H); 2.63 (dd, J=14,7 Hz, 1H) ; 2.86 (dd, J=14,5. 8 Hz, 1H); 3.09 (t, J=6. 9 Hz, 2H); 3.12 (s, 3H); 3.52-3. 63 (m, 2H); 3.84-3. 87 (m, 1H) ; 4.27 (t, J=6.8 Hz, 2H); 6.48 (d, J=8. 8 Hz, 2H); 6.52 (d, J=3.4 Hz, 1H) ; 6.98 (d, J=8.8 Hz, 2H); 7.12 (dd, J=8.8, 2.4 Hz, 1H) ; 7.18 (d, J=3 Hz, 1H) ; 7.32 (d, J=8.8 Hz, 1H) ; 7.54 (d, J=2.1 Hz, 1H).

IR (neat) cm-1 : 3384,2933, 1712,1615, and 1520.

Mass m/z (ES): 475 [M + 1], 497 [M + 23].

Example 33 2-Ethoxy-3- [4- {3- (2, 3-dihydroindol-1-yl) propylamino} phenyl] propanoic acid Yield: 280 mg, 72 %.

'H NMR (CDC13, 400 MHz) 8 : 1.17 (t, J=7.3 Hz, 3H); 1.92 (quintet, J=6.8 Hz, 2H); 2.89 (dd, J=14.2, 7.8 Hz, 1H) ; 2.96 (t, J=8. 3 Hz, 2H); 3.02 (dd, J=14.2, 3.9 Hz, 1H); 3.17 (t, J=6.9 Hz, 2H); 3.24 (t, J=6.9 Hz, 2H) ; 3. 34 (t, J=8.3 Hz, 2H); 3. 42-3. 50 (m, 1H); 3.53-3. 61 (m, 1H); 4.02 (dd, J=7.8, 3.9 Hz, 1H); 6.48 (d, J=7.8 Hz, 1H) ; 6.55 (d, J=8.3 Hz, 2H) ; 6.66 (dt, J=7. 3, 1 Hz, 1H) ; 7.03-7. 09 (aromatics, 4H).

IR (neat) cm'l : 3391,2927, 1725,1607, and 1520.

Mass m/z (CI): 369 [M + 1].

Example 34 2-Ethoxy-3-[4-{(6-methanesulfonyloxy-1,2,3,4-tetrahydronapth -2- yl) methylamino} phenyll propanoic acid Yield: 55 mg, 58 %.

'H NMR (CDCl3, 400 MHz) Ja : 1.19 (t, J=7Hz, 3H); 1. 42-1.55 (m, 1H) ; 2.00-2. 15 (m, 2H); 2.52 (dd, J= 16,10 Hz, 1H) ; 2.80-3. 15 (m, 7H); 3.12 (s, 3H); 3. 42-3. 60 (m, 2H); 4.04 (dd, J=7.3, 4.3 Hz, 1H) ; 6.58 (d, J=8.3 Hz, 2H); 7.03-7. 12 (aromatics, 5H).

IR (neat) cm'' : 3500,2927, and 1728.

Mass m/z (ES): 448 [M + 1], 470 [M+23].

Example 35 2-Ethoxy-3- [4- {3- (6-methanesulfonyloxy-1, 2,3, 4-tetrahydronapth-2-yl) propylamino} phenyl] propanoic acid Yield : 75 mg, 69 %.

'H NMR (CDC13, 400 MHz) 8 : 1.15 (t, J=7Hz, 3H); 1.20-1. 80 (m, 7H); 1.82-2. 00 (m, 1H); 2.40 (dd, J= 16,10 Hz, 1H) ; 2.75-2. 85 (m, 2H); 2.85-3. 10 (m, 2H); 3.10- 3.20 (m, 4H); 3.45-3. 55 (m, 1H) ; 3.55-3. 70 (m, 2H); 4.0 5 (dd, J=7.4, 4.4 Hz, 1H) ; 6.68 (d, J=8.3 Hz, 2H); 6.98-7. 09 (aromatics, 5H).

IR (neat) cm-1 : 3503,2928, and 1694.

Mass m/z (CI) : 476 [M + 1], 498 [M+23].

Example 36 2-Ethoxy-3- [4- {3- (1, 2,3, 4-tetrahydroquinolyn-1-yl) propylamino} phenyl propanoic acid Yield: 215 mg, 58 %.

'H NMR (CDC13, 400 MHz) S : 1.18 (t, J=7 Hz, 3H); 1.90-1. 96 (m, 4H); 2.75 (t, J=7 Hz, 2H); 2.89 (dd, J=14,7 Hz, 1H) ; 3.03 (dd, J=14,4 Hz, 1H) ; 3.18 (t, J=7 Hz, 2H); 3.27 (t, J=6.9 Hz, 2H); 3.37 (t, J=7 Hz, 2H) ; 3.42-3. 50 (m, 1H) ; 3.50-3. 60 (m, 1H) ; 4.02 (dd, J=7, 4 Hz, 1H) ; 6. 53-6.59 (aromatics, 4H); 6.94 (d, J=7.3 Hz, 1H) ; 7.00-7. 06 (aromatics, 3H).

IR (neat) cm-1 : 3400,2928, 1725,1601.

Mass m/z (CI): 383 [M + 1].

Example 37 2-Methyl-2- [4- {6-methanesulfonyloxynapth-2-ylmethoxy} phenoxy] propanoic acid Mp: 147-149 °C. Yield: 98 mg, 36 %.

'H NMR (CDC13, 400 MHz)) 8 : 1.53 (s, 6H); 3.22 (s, 3H); 5.18 (s, 2H); 6.86-6. 93 (aromatics, 4H); 7.40-7. 43 (aromatics, 2H); 7.60 (d, J=8 Hz, 1H) ; 7.86-7. 92 (aromatics, 3H) IR (neat) cm-1 : 3430,2924, 1715, and 1504.

Mass m/z (CI): 448.3 [M + NH4], 878.5 [M2+NH4].

Example 38 2-Methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyloxy} phenoxy] propanoic acid Yield: 300 mg, 85 %.

IH NMR (CDC13,400 MHz) 8 : 1.54 (s, 6H); 2.26 (quintet, J=6 Hz, 2H); 3.12 (s, 3H); 3.82 (t, J=5.6 Hz, 2H); 4.37 (t, J=6.4 Hz, 2H); 6.49 (d, J=3 Hz, 1H) ; 6.77 (d, J=8.8 Hz, 2H); 6. 91 (d, J=8.8 Hz, 2H); 7.08 (dd, J=8.8, 2.4 Hz, 1H); 7.15 (d, J=3.3 Hz, 1H) ; 7.32 (d, J=8.8 Hz, 1H) ; 7.51 (d, J=2.1 Hz, 1H).

IR (neat) cm-1 : 3400,2937, 1717, 1611, and 1505.

Mass m/z (ES): 448 [M + 1], 470 [M + 23].

Example 39 2-Methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxyl propanoic acid Yield: 170 mg, 52 %.

'H NMR (CDCl3, 400 MHz) 8 : 1.57 (s, 6H); 2.16 (quintet, J=7.3 Hz, 2H); 2.58 (t, J=7.7 Hz, 2H); 3.12 (s, 3H); 4.12 (t, J=7 Hz, 2H) ; 6.50 (d, J=2.7 Hz, 1H) ; 6.87 (d, J=8.6 Hz, 2H); 7.05 (d, J=8.6 Hz, 2H); 7.09-7. 15 (aromatics, 2H); 7.22 (d, J=8.8 Hz, 1H); 7.52 (d, J=2.4 Hz, 1H).

IR (neat) cm'' : 3326,2937, 1716,1609, and 1508.

Mass m/z (CI): 432 [M + 1].

Example 40 2-Methyl-2- {4- {3- (3, 4-dihydro-2H-bezo [b] [1, 4] Oxazin-4-yl) propyl} phenoxy propanoic acid Yield: 70 mg, 45 %.

'H NMR (CDC13, 400 MHz) 8 : 1.47 (s, 6H); 1.78 (quintet, J=7.5 Hz, 2H); 2.55 (t, J=7.6 Hz, 2H); 3.20-3. 30 (m, 4H); 4.13 (t, J=4. 3 Hz, 2H); 6.47 (dt, J=Hz, 1H) ; 6.56 (dd, J=Hz, 1H) ; 6.63 (dd, J=Hz, 1H) ; 6.67-6. 73 (aromatics, 1H) ; 6.76 (d, J=8.6 Hz, 2H); 7.11 (d, J=8. 6 Hz, 2H).

IR (neat) cm-1 : 3400,2932, 1715,1606, and 1506.

Mass m/z (ES): 356 [M + 1].

Example 41 2-Methyl-2-[4-{3-(3-methanesulfonyloxyphenoxy) propyl} phenoxy] propanoic acid Yield: 260 mg, 56 %.

1H NMR (CDCl3, 400 MHz) 8 : 1. 58 (s, 6H); 2.04-2. 11 (m, 2H); 2.76 (t, J=7. 3 Hz, 2H); 3.13 (s, 3H); 3.95 (t, J=6.2 Hz, 2H); 6.79-6. 86 (aromatics, 3H); 6. 87 (d, J=8. 8 Hz, 2H); 7.11 (d, J=8.8 Hz, 2H); 7.28 (t, J=8. 4 Hz, 1H).

IR (neat) cm-1: 3400, 2939,1717, 1608,1508.

Mass m/z (ES): 409 [M+1], 426 [M+18], 431 [M + 23].

Example 42 2-Methyl-2- [3- {3- (4-methanesulfonyloxyphenoxy) propyl} phenoxy] propanoic acid Mp: 93-95 °C. Yield: 255 mg, 74 %.

'H NMR (CDC, 400 MHz) b : 1.57 (s, 6H); 2.04-2. 17 (m, 2H); 2.77 (t, J=7. 1 Hz, 2H); 3.11 (s, 3H); 3.93 (t, J=6. 2 Hz, 2H); 6.75-6. 79 (aromatics, 2H); 6.88 (d, J=9.1 Hz, 2H); 6.92 (d, J=7.5 Hz, 1H) ; 7.17-7. 21 (aromatics, 3H).

IR (neat) cm-1 : 3375,2938, 1716,1585, 1502.

Mass m/z (ES): 409 [M+1], 426 [M+18], 431 [M + 23].

Example 43 2-Methyl-2- [4- {3- (4-methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoic acid Yield: 115 mg, 58 %.

'H NMR (CDC13, 400 MHz) 8 : 1.53 (s, 6H); 2.24 (quintet, J=6 Hz, 2H); 3.10 (s, 3H); 4.11 (t, J=6.2 Hz, 2H); 4.14 (t, J= 6.1 Hz, 2H); 6.81 (d, J=9 Hz, 2H); 6.88- 6.93 (aromatics, 4H) ; 7.19 (d, J=9 Hz, 2H).

IR (neat) cm-1: 3355,2936, 1718,1593, 1503.

Mass m/z (ES): 425 [M+1], 442 [M+18], 447 [M+23].

Example 44 2-Methyl-2-[3-{3-(3-methanesulfonyloxyphenoxy)propyloxy}phen oxy]propanoic acid Yield: 250 mg, 59 %.

'H NMR (CDC13,400 MHz) 8 : 1.60 (s, 6H); 2.24 (quintet, J=6 Hz, 2H); 3.12 (s, 3H); 4.11 (t, J=6 Hz, 2H); 4.14 (t, J=6.2 Hz, 2H) ; 6. 50-6.62 (aromatics, 3H); 6.85- 6.88 (aromatics, 3H) ; 7.14 (t, J=8 Hz, 1H) ; 7.29 (t, J=8.3 Hz, 1H).

IR (neat) cm-1 : 2936,1732, 1603,1486.

Mass m/z (ES): 425 [M+1], 442 [M+181, 866 [M2 + 181.

Example 45 <BR> <BR> (S)-2-Methoxy-3- [4-{6-methanesulfonyloxynapth-2-ylmethylamino} phenyl] propanoic acid Arginine salt (S) -2-methoxy-3- [4- {6-methanesulfonyloxynapth-2-ylmethylamino} phenyl] propanoic acid (100 mg, 1 eq, 0.233 mmol) obtained in example 23, and L-Arginine (40.6 mg, 1 eq, 0.233 mmol) were taken in dry methanol (3 ml), and stirred at RT for 2-3 h. The solvent was removed on rotavapor followed by benzene azeotrope. The residue was dried under high vacuum pump to yield the title compound as a free flowing white solid (138 mg, yield 100 %).

Mpt: 122-124 °C.

The following examples (examples 46-61) were made using the typical procedure described for example 45.

Example 46 2-Ethoxy-5- [4-{6-methanesulfonyloxynapth-2-ylmethylamino} phenyl] pentatonic acid Arginine salt Mp: 118-120 °C.

Example 47 2-Ethoxy-3- [4- {3- (indol-1-yl) propyl amino} phenyl] propanoic acid Arginine salt Mp: 130°C.

Example 48 <BR> <BR> (S) -2-Methoxy-3- [4- {3- (indol-1-yl) propyl amino} phenyl] propanoic acid Arginine salt Mp : 105 °C.

Example 49 (S)-2-Ethoxy-3-[4-{3-(5-methanesulfonyloxyindol-1-yl) propylamino} phenyl] propanoic acid Arginine salt Mp: 102-104 °C.

Example 50 <BR> <BR> (S) -2-Methoxy-3- [4- {3- (5-methanesulfonyloxyindol-1-yl) propylamino} phenyl] propanoic acid Arginine salt Mp : 102-104 °C.

Example 51 (S)-3-Ethoxy-4-[4-{3-(5-methanesulfonyloxyindol-1-yl) propylamino} phenyl] butanoic acid Arginine salt Mp: 98-100 °C.

Example 52 2-Ethoxy-3- [4- {3- (2, 3-dihydroindol-1-yl) propylamino} phenyl] propanoic acid Arginine salt Mp: 130-132 °C.

Example 53 2-Ethoxy-3-[4-{(6-methanesulfonyloxy-1-, 2,3, 4-tetrahydronapth-2- yl) methylamino} phenyl propanoic acid Arginine salt Mpt : 96-98 °C.

Example 54 2-Ethoxy -3-[4-{3-(6-methanesulfonyloxy-1-, 2,3, 4-tetrahydronapth-2-yl) propylamino} phenyl] propanoic acid Arginine salt Mp : 115-117 °C.

Example 55 2-Ethoxy-3- [4-{3-(1, 2,3, 4-tetrahydroquinolyn-1-yl) propylamino} phenyl propanoic acid Arginine salt Mp: 134-136 °C.

Example 56 2-Methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyloxy} phenoxy] propanoic acid Arginine salt Mp: 125 °C.

Example 57 2-Methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] propanoic acid Arginine salt Mp: 80 °C.

Mass m/z (ES): 606 {M+1].

Example 58 2-Methyl-2- [4- {3- (3, 4-dihydro-2H-bezo [b] [1, 4] Oxazin-4-yl) propyl} phenoxy] propanoic acid Arginine salt Mp: 78 °C.

Example 59 2-Methyl-2- [4- {3- (3-methanesulfonyloxyphenoxy) propyl} phenoxy] propanoic acid Arginine salt Riz mso I,, o 02H. Arginine Mp : 95-97 °C.

Example 60 2-Methyl-2- [4- {3- (4-methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoic acid Arginine salt Mp: 82-84 °C.

Mass m/z (ES): 599 [M+1].

Example 61 2-Methyl-2- [3- {3- (3-methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoic acid Arginine salt mso 0\ 01" ( 0 C02H Arginine I11- M. p : 110-112 °C.

Example 62 Ethyl 2- {4- [3- (biphenyl-4-yloxy)-propyl]-phenoxy}-2-methyl-propanoate To 4-phenylphenol (400mg, 2.35mmol) dissolved in DMF (lOmL) was added K2C03 (973mg, 7. 05mmol) and stirred at room temperature for 15min. and then was added ethyl- 2- [4- (3-methanesulphonyloxy-propyl)-phenoxy]-2-methyl-propanoate (808mg, 2. 35mmol) (obtained in preparation 16) in DMF (5mL) and the mixture was stirred at 80°C for 12h and the mixture was cooled to RT and filtered off, washed the K2CO3 cake with ethyl acetate (lOOmL) the combined filtrates were washed with water thrice and then with brine, dried over Na2SO4 and evaporated the ethyl acetate to get a crude product which was purified on silica gel column by eluting with 20% ethyl acetate and hexane to give a thick gum of ethyl 2- {4-[3-(biphenyl-4-yloxy)-propyl]-phenoxy}-2-methyl-propanoat e (450 mg, 46%).

'H NMR (6, CDC13, 200MHz) : 7.60-7. 20 (m, 7H), 7.08 (d, J=8. 55Hz, 2H), 6.95 (d, J=8.78Hz, 2H), 6.78 (d, J=8. 55Hz, 2H), 4.23 (q, J=7.08Hz, 2H), 3.98 (t, J=6. 1 lHz, 2H), 2.76 (t, J=7.08Hz, 2H), 2.20-2. 00 (m, 2H), 1.16 (s, 6H), 1.28 (t, J=7.08Hz, 3H).

Example 63 2- {4- [3- (Biphenyl-4-yloxy)-propyl]-phenoxy}-2-methyl-propanoic acid Ethyl 2- {4- [3- (biphenyl-4-yloxy)-propyl]-phenoxy}-2-methyl-propanoate obtained in example 62 was hydrolyzed with aqueous LiOH at 25 °C for 12 h in methanol. THF mixture (3 mL+2 mL) after the completion of reaction the solvent was evaporated and the aqueous layer was washed once with ether and the aqueous layer was acidified with 2 N HCl to pH 2 and extracted with EtOAc and the organic layer was dried with Na2SO4 and evaporated under reduced pressure to give 2-14- [3- (biphenyl-4-yloxy)-propyl]-phenoxy)- 2-methyl-propanoic acid (83%).

M. P : 130-133°C ; 'H NMR (8, CDC13, 200MHz) : 7. 55-7. 29 (m, 7H), 7.13 (d, J=8. 60Hz, 2H), 6.95 (d, J=8.59Hz, 2H), 6.88 (d, J=8. 60Hz, 2H), 3.99 (t, J=6.18Hz, 2H), 2.79 (t, J=7. 30Hz, 2H), 2.13-2. 00 (m, 2H), 1.60 (s, 6H).

Example 64 Ethyl 2-methyl-2-13-{3-(4- methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoate Obtained by following procedure of example 18 using starting materials obtained in preparation 11 and 13.

Yield: 357 mg, 49% IH NMR (CDCI3, 400 MHz) 8 : 1.23 (t, J=7.2 Hz, 3H); 1.59 (s, 6H); 2.23 (quintet, J= 6 Hz, 2H); 3.10 (s, 3H); 4.10 (t, J=6 Hz, 2H); 4.13 (t, J= 6 Hz, 2H); 4.23 (q, J=7.2 Hz, 2H); 6. 38-6. 41 (aromatics, 1H) ; 6.44-6. 45 (aromatics, 1H) ; 6.53-6. 56 (aromatics, 1H) ; 6.91 (d, J=9.2 Hz, 2H); 7.11 (t, J= 8.4 Hz, 1H) ; 7.19 (d, J=9.2 Hz, 2H).

IR (neat) cm-1 : 2938,1731, 1597,1502.

Mass m/z (CI) : 453 [M+1] Example 65 2-Methyl-2- [3- {3- (4-methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoic acid Obtained from example 64 by following procedure of example 23.

Yield: 120 mg, 36 %.

'H NMR (CDC13,'400 MHz) 8 : 1.60 (s, 6H); 2.24 (quintet, J=6 Hz, 2H); 3.10 (s, 3H); 4.11 (t, J=6 Hz, 2H); 4.14 (t, J=6.2 Hz, 2H); 6.51-6. 53 (aromatics, 2H); 6.62-6. 65 (aromatics, 1H); 6.91 (d, J=9.1 Hz, 2H); 7.16-7. 20 (aromatics, 3H) IR (neat) cm- : 2937,1717, 1596,1502.

Mass m/z (ES): 425. 1 [M+1], 442.3 [M+18], 866.5 [M2 + 18].

Example 66 <BR> <BR> <BR> 2-Methyl-2-13-{3-(4-methanesulfonyloxyphenoxy) propyloxy} phenoxy] propanoic acid Arginine salt OO OC02H. Arginine Fizz mus0 Obtained from example 65 by following procedure of example 45 Mp: 88-90 °C.

Mass m/z (ES): 599.5 [M+1].

Example 67 Ethyl 2-methyl-2-[3-{3-(5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] propanoate Obtained by following procedure of example 17 and using starting materials obtained in step-1 of preparation 7 and preparation 18.

Thick liquid. Yield: 600 mg (83 %).

'H NMR (CDC13, 400 MHz) 8 : 1.22 (t, J=7.2 Hz, 3H); 1.59 (s, 6H); 2.15 (quintet, J=7. 2 Hz, 2H); 2.58 (t, J=7.2 Hz, 2H); 3.12 (s, 3H); 4.11 (t, J=7. 2 Hz, 2H); 4. 21 (q, J=7.2 Hz, 2H); 6.51 (d, J=2.8 Hz, 1H) ; 6 66-6. 70 (aromatics"2H) ; 6.78 (d, J=7.6 Hz, 1H); 7.10-7. 24 (aromatics, 4H); 7.53 (d, J=2.4 Hz, 1H).

IR (Neat, cm'') : 2935,1731, 1583,1363.

Mass m/z (CI) : 460 [M+1].

Example 68 2-methyl-2- [3- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] propanoic acid Obtained from example 67 by following procedure of example 23.

Thick liquid. Yield: 331 mg (67 %).

'H NMR (CDCl3, 400 MHz) S : 1.58 (s, 6H); 2.15 (quintet, J=7.2 Hz, 2H) ; 2.56 (t, J=7.6 Hz, 2H); 3. 12 (s, 3H); 4.11 (t, J=7.2 Hz, 2H); 6.51 (d, J=3.2 Hz, 1H) ; 6.73 (s, 1H) ; 6.74- 6. 79 (aromatic, 1H) ; 6.86 (d, J=7.6 Hz, 1H) ; 7.10-7. 24 (aromatics, 4H); 7.52 (d, J=2.4 Hz, 1H).

IR (Neat, cm-1) : 3362,2937, 1717,1362.

Mass m/z (ES): 432.3 [M+1], 449.4 [M+NH4+], 453.3 [M+Na+], 880.5 [M2+NH4+].

Example 69 2-methyl-2- [3-{3-(5-methanesulfonyloxyindol-1-yl) propyl} phenoxyl propanoic acid Arginine salt Obtained from example 68 by following procedure of example 45.

Mp: 85-87 °C (dec).

Mass m/z (ES): 606 [M+1].

Example 70 Ethyl 2-methyl-2-[3-{3-(7-Methanesulfonyloxy-3,4-dihydro-2H-bezo [b] [1, 4] oxazin- 4-yl) propyl} phenoxy] propanoate This compound was made using the typical procedure described for example 18 except that Na2CO3 was used as base instead of K2C03, and also a mixture of MeCN/DMF was used as solvent instead of DMF alone. Starting materials were obtained from preparation 19 and 24. Yield: 170 mg, 10 %.

'H NMR (CDCl3, 400 MHz) 5 : 1.24 (t, J=7.2 Hz, 3H); 1.59 (s, 6H); 1. 80-1: 91 (m, 2H); 2.61 (t, J=7.6Hz, 2H); 3.07 (s, 3H); 3.22 (t, J=7.2Hz, 2H); 3.29 (t, J=4.4Hz, 2H); 4.19-4. 26 (m, 4H); 6.46 (d, J=8. 8Hz, 1H) ; 6.65-6. 68 (aromatic, 2H); 6.71-6. 72 (aromatic, 2H); 6.81-6. 84 (aromatic, 1H) ; 7.12-7. 17 (aromatic, 1H).

IR (Neat, cm-1) : 3397,2927, 1730,1585.

Mass m/z (CI) : 478 [M+1].

Example 71 (+) Methyl (R)-2-methyl-2-14-{3-(5-methanesulfonyloxyindol-1-yl) propyl} phenoxy butanoate A solution of powdered KOH (203 mg, 1.6 eq, 3.62 mmol) in dry DMSO (8 mL) was stirred at RT for 10 min, then 5-methanesulfonyloxyindole (956 mg, 2 eq, 4.53 mmol), obtained in step 1 of preparation 7, was added portion wise at RT and stirring was continued at RT for 20 min. Then methyl (R)-2-methyl-2- [4- (3- methanesulfonyloxypropyl) phenoxy] butanoate (780 mg, 1 eq, 2.27 mmol), obtained in preparation 31, in 3 mL of dry DMSO was added drop wise at RT. And the reaction was stirred at RT for 2 h. Being guided by TLC, reaction was stopped. Reaction mixture was diluted with ethyl acetate (150 mL), and washed with water (2x100 mL). Organic layer was dried (Na2SO4), condensed, and the residue was chromatographed using ethyl acetate and hexane to obtain the title compound as thick mass. (875 mg, 88% yield).

'H NMR (CDC13, 400 MHz) 8 : 0.98 (t, J=7.6 Hz, 3H); 1.48 (s, 3H); 1. 94-1. 99 (m, 2H); 2.14 (quintet, J=7.2 Hz, 2H); 2.56 (t, J=7.6 Hz, 2H); 3.12 (s, 3H); 3.77 (s, 3H); 4.10 (t, J=6.8 Hz, 2H); 6.50 (d, J=3.2 Hz, 1H) ; 6.77 (d, J=8.4 Hz, 2H); 7.01 (d, J=8.4 Hz, 2H); 7.11 (dd, J= 2.4, 8.8 Hz, 1H) ; 7.14 (d, J= 3.2 Hz, 1H) ; 7.23 (d, J= 8. 8 Hz, 1H) ; 7.52 (d, J=2.4 Hz, 1H).

IR (neat) cm-1 : 2942,1736, 1509,1360.

Mass m/z (CI): 460 [M + 1].

[a] D = +13 ° (c = 1%, MeOH, 25 °C).

Example 72 (-) Methyl (, S-2-methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] butanoate The title compoundwhich is an enantiomer of example 71 was obtained following the procedure for example 71 and using starting material obtained in preparation 32.

[a] D=-13.2° (c = 1%, MeOH, 25 °C) Using the typical procedure described in example 15 and 18 the following examples (examples 73-77) have been obtained.

Example 73 Ethyl 2-methyl-2- [3- {3- (4- (para- toluenesulfonyloxy) phenoxy) propyloxy} phenoxylpropanoate Yield: 825 mg, 89 %.

'H NMR (CDC13, 400 MHz) 8 : 1.23 (t, J=7. 1 Hz, 3H); 1.59 (s, 6H) ; 2.20 (quintet, J=6. 1 Hz, 2H); 2.44 (s, 3H); 4.07 (t, J=6. 1 Hz, 4H); 4.22 (q, J=7. 1 Hz, 2H) ; 6.40 (ddd, J=8. 1,2. 3,0. 6 Hz, 1H) ; 6.44 (t, J=2. 3 Hz, 1H) ; 6. 53 (ddd, J=8. 1,2. 3,0. 6 Hz, 1H) ; 6.76 (d, J=9. 1 Hz, 2H) ; 6.86 (d, J=9. 1 Hz, 2H); 7.10 (t, J=8. 1 Hz, 1H) ; 7. 30 (d, J=8. 1 Hz, 2H); 7.68 (d, J=8. 1 Hz, 2H).

IR (neat) cm-1 : 2985,1733, 1598,1501, 1172.

Mass m/z (CI) : 529 [M+1].

Example 74 Ethyl 2-methyl-2-[4-{3-(4- methanesulfonyloxyphenoxy) propyloxy} phenoxy] butanoate Obtained using starting materials from preparation 13 and 26.

Yield: 825 mg, 89 %.

'H NMR (CDCl3, 400 MHz) 8 : 0.98 (t, J=7. 5 Hz, 3H); 1.27 (t, J=7. 1 Hz, 3H); 1.41 (s, 3H) ; 1.88-2. 00 (m, 2H) ; 2.20-2. 26 (m, 2H); 3.09 (s, 3H); 4.09 (t, J=6 Hz, 2H); 4.14 (t, J=6 Hz, 2H) ; 4.24 (q, J=7. 1 Hz, 2H) ; 6.77 (d, J=9. 4 Hz, 2H); 6.83 (d, J=9. 4 Hz, 2H); 6.90 (d, J=9. 1 Hz, 2H); 7.19 (d, J=9. 1 Hz, 2H).

IR (neat) cm-1 : 2977,1731, 1504, 1196.

Mass m/z (CI): 467 [M+1].

Example 75 Ethyl 2-methyl-2- 4-{4- (4-methanesulfonyloxyphenoxy) butyl} phenoxy] propanoate Obtained using starting materials from preparation 12 and 35.

Yield: 400 mg, 55 %.

'H NMR (CDC13, 400 MHz) S : 1.25 (t, J=7. 2 Hz, 3H); 1.57 (s, 6H); 1.75-1. 82 (m, 4H); 2.61 (t, J=7. 3 Hz, 2H); 3.10 (s, 3H); 3.94 (t, J=5. 9 Hz, 2H); 4.26 (q, J=7. 2 Hz, 2H); 6.77 (d, J=8. 6 Hz, 2H); 6.88 (d, J=8. 9 Hz, 2H); 7.05 (d, J=8. 5 Hz, 2H) ; 7.18 (d, J=8. 9 Hz, 2H).

IR (neat) cm-1 : 2938,1729, 1593,1502, 1149.

Mass m/z (CI) : 451 [M+1].

Example 76 Ethyl 2-methyl-2-[3-{5-(4-methanesulfonyloxyphenoxy) pentyl} phenoxy] propanoate Obtained using starting materials from preparation 12 and 36.

Yield: 625 mg, 42 %.

'H NMR (CDC13,400 MHz) 8: 1.23 (t, J=7 2 Hz, 3H); 1.42-1. 55 (m, 2H); 1.58 (s, 6H) ; 1.60-1. 75 (m, 2H); 1.75-1. 85 (m, 2H) ; 2.58 (t, J=7. 6 Hz, 2H); 3.1 (s, 3H); 3.92 (t, J=6. 5 Hz, 2H); 4.22 (q, J=7. 2 Hz, 2H); 6.64 (dd, J=8. 1,2. 4 Hz, 1H) ; 6.70 (s, 1H) ; 6.80 (d, J=7. 5 Hz, 1H) ; 6.87 (d, J=9. 2 Hz, 2H); 7.13 (t, J=7. 6 Hz, 1H) ; 7.18 (d, J=9. 2 Hz, 2H).

IR (neat) cm-1 : 2938,1732, 1602,1502, 1151.

Mass m/z (ES): 464 [M], 465 [M+1] Example 77 Ethyl 2-methyl-2- [3- {5- (4-nitrophenoxy) propyl} phenoxy] propanoate Obtained using starting material from preparation 16 and reacting with 4- nitrophenol.

Yield: 170 mg, 75 %.

'H NMR (CDC13, 200 MHz) 8 : 1.25 (t, J=7. 2 Hz, 3H); 1.57 (s, 6H); 2.08-2. 12 (m, 2H) ; 2.75 (t, J=7. 4 Hz, 2H); 4.02 (t, J=6. 2 Hz, 2H); 4.23 (q, J=7. 2 Hz, 2H); 6.77 (d, J=8. 4Hz, 2H); 6.92 (d, J=9. 1 Hz, 2H); 7.05 (d, J=8. 4 Hz, 2H); 8.19 (d, J=9. 1 Hz, 2H).

IR (neat) cm'' : 2937,1733, 1519,1262.

Mass m/z (CI) : 388 [M+1].

Example 78 Ethyl 2-methyl-2- [3- {5- (4-aminophenoxy) propyl} phenoxy] propanoate Obtained using starting materials from example 77 and doing hydrogenation (10 % Pd/C, H2 (1 atm) ) in ethyl acetate solvent at RT.

Yield: 825 mg, 97 %.

'H NMR (CDCI3, 400 MHz) b : 1.24 (t, J=7. 2 Hz, 3H); 1.56 (s, 6H); 2.0-2. 08 (m, 2H); 2.71 (t, J=7. 6 Hz, 2H); 3.86 (t, J=6. 4 Hz, 2H); 4.22 (q, J=7. 2 Hz, 2H); 6.62 (d, J=8. 8Hz, 2H); 6.72 (d, J=8. 8 Hz, 2H); 6.76 (d, J=8. 7 Hz, 2H); 7.05 (d, J=8. 7 Hz, 2H).

IR (neat) cm'' : 3366,2938, 1731,1510, 1233,1140.

Mass m/z (CI) : 358 [M+1].

Example 79 Ethyl 2-methyl-2-[4-{3-(4-(tert- butyloxycarbonylamino) phenoxy) propyl} phenoxy] propanoate Obtained using starting materials from example 78 and reacting with (BOC) 20 in presence of triethylamine in dichloromethane solvent at 0-RT for 3h.

Yield: 143 mg, 28 %.

'H NMR (CDC13,400 MHz) 8 : 1.24 (t, J=7. 2 Hz, 3H); 1.38 (s, 2.25H, minor rotamer); 1.44 (s, 6.75H, major rotamer); 1.57 (s, 6H); 2.0-2. 08 (m, 2H); 2.72 (t, J=6. 4 Hz, 2H); 3.93 (t, J=6. 4 Hz, 2H) ; 4.23 (q, J=7. 2 Hz, 2H); 6.77 (d, J=8. 6 Hz, 2H); 6.83 (d, J=9. 0 Hz, 1.5H, major rotamer); 6.87 (d, J=9. 0 Hz, 0. 5H, minor rotamer); 7.05 (d, J=8. 6 Hz, 2H); 7.06 (bs, NH, 1H) ; 7.14 (d, J=9. 0 Hz, 1. 5H, major rotamer); 7.44 (d, J=9. 0 Hz, 0. 5H, minor rotamer).

IR (neat) cm'' : 3381, 2934,1734, 1509,1241, 1145.

Mass m/z (CI): 457 [M], 458 [M+1].

Example 80 Ethyl 2-methyl-2-[4-{3-(4- (methanesulfonylamino) phenoxy) propyl} phenoxy] propanoate Obtained using starting material from example 78 and reacting with methanesulfonyl chloride in presence of triethylamine in dichloromethane solvent at 0- RT for 4h.

Yield: 400 mg, 79 %.

'H NMR (CDC13, 400 MHz) 8 : 1.25 (t, J=7Hz, 3H); 1.57 (s, 6H); 2.00-2. 08 (m, 2H); 2.72 (t, J=7. 5 Hz, 2H); 3.38 (s, 3H); 3.95 (t, J=6. 2 Hz, 2H); 4.23 (q, Y=7Hz, 2H); 6.78 (d, J=8. 6 Hz, 2H); 6.91 (d, J=8. 8 Hz, 2H); 7.05 (d, J=8. 6 Hz, 2H); 7.24 (d, J=8. 8 Hz, 2H).

IR (neat) cm-1 : 3383,2926, 1732,1367, 1162.

Mass m/z (CI): 436 [M+1].

Using the typical procedure described in example 17 and 71 the following examples (examples 81-86) have been obtained.

Example 81 Ethyl 2-methyl-2- [4- {4- (5-methanesulfonyloxyindol-1-yl) butyl} phenoxy] propanoate Obtained using starting material from step-1 of preparation 7 and preparation 35.

Yield: 640 mg, 57 %.

'H NMR (CDC13, 400 MHz) 5 : 1.24 (t, J=7. 3 Hz, 3H); 1.56 (s, 6H); 1.57-1. 65 (m, 2H); 1.80-1. 90 (m, 2H); 2.55 (t, J=7. 5 Hz, 2H); 3.12 (s, 3H); 4.11 (t, J=6. 8 Hz, 2H); 4.22 (q, J=7. 3 Hz, 2H); 6.49 (dd, J=3. 2,0. 6 Hz, 1H) ; 6. 75 (d, J=8. 6 Hz, 2H); 6.97 (d, J=8. 6 Hz, 2H); 7.10-7. 15 (aromatics, 2H); 7.28 (d, J=8. 8 Hz, 1H); 7.51 (d, J=2. 2 Hz, 1H).

IR (neat) cm'' : 2937,1732, 1177.

Mass m/z (CI): 474 [M+1].

Example 82 Ethyl 2-methyl-2- [3- {3- (5- (para-toluenesulfonyloxy) indol-1-yl) propyl} phenoxy] propanoate Obtained using starting materials from preparation 18 and 34.

Yield: 110 mg, 12 %.

'H NMR (CDC13, 400 MHz) 8 : 1.24 (t, J=7. 2 Hz, 3H) ; 1. 61 (s, 6H); 2.14 (quintet, J=7. 3 Hz, 2H) ; 2.46 (s, 3H) ; 2.58 (f, J=7. 3 Hz, 2H); 4.09 (t, J=7. 3 Hz, 2H); 4.23 (q, J=7. 2 Hz, 2H); 6.42 (d, J=9, 2.9 Hz, 1H) ; 6.68-6. 78 (aromatics, 2H); 6.79-6. 84 (aromatics, 2H); 7.12-7. 32 (aromatics, 6H); 7.74 (d, J=8. 4 Hz, 2H).

IR (neat) cm-1 : 2985, 2929,1732, 1599,1178.

Mass m/z (CI): 536 [M+1].

Example 83 Ethyl 2- [3- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] propanoate Obtained using starting material from step-1 of preparation 7 and preparation 37.

Yield: 350 mg, 60 %.

'H NMR (CDCI3, 400 MHz) 8 : 1.22 (t, J=7. 2 Hz, 3H); 1. 60 (d, J=6. 7 Hz, 3H); 2.10-2. 20 (m, 2H); 2.59 (t, J=7. 5 Hz, 2H) ; 3.12 (s, 3H); 4.11 (t, J=7. 0 Hz, 2H); 4.20 (q, J=7. 2 Hz, 2H); 4.72 (q, J=6. 7 Hz, 1H) ; 6. 51 (d, J=0. 6 Hz, 1H) ; 6.70-9- 6.82 (aromatics, 3H); 7.10-7. 25 (aromatics, 4H); 7.52 (d,. J=2. 2 Hz, 1H).

IR (neat) cm-1 : 2936, 1747,1175.

Mass m/z (CI): 446 [M+1].

Example 84 1-[4-{3-(5-Methanesulfonyloxyindol-1-yl)propyl}phenoxy]cyclo hexane-1-carboxylic acid, methyl ester Obtained using starting material from step-1 of preparation 7 and preparation 38.

Yield: 190 mg, 36 %.

1H NMR (CDCl3, 400 MHz) 8 : 1.50-1. 75 (m, 6H); 1.82-1. 92 (m, 2H); 2.05-2. 20 (m, 4H); 2. 55 (t, J=7. 6 Hz, 2H); 3.11 (s, 3H); 3.75 (s, 3H); 4.10 (t, J=7. 4 Hz, 2H); 6.50 (d, J=2. 8 Hz, 1H); 6.75 (d, J=8. 6 Hz, 2H); 7.01 (d, J=8. 6 Hz, 2H); 7.09-7. 17 (aromatics, 2 H); 7.22 (d, J=8. 8 Hz, 1H) ; 7.52 (d, J=2. 2 Hz, 1H).

IR (neat) cm-' : 2938,2859, 1733,1508, 1364,1224, 1178.

Mass m/z (CI) : 486 [M+1].

Example 85 <BR> <BR> <BR> 1- [4- 3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] cyclopentane-1-carboxylic acid, methyl ester Obtained using starting material from step-1 of preparation 7 and preparation 39.

Yield: 780 mg, 92 %.

'H NMR (CDCl3, 400 MHz) 8 : 1.72-1. 86 (m, 4H) ; 2.10-2. 21 (m, 4H); 2. 21-2.30 (m, 2H); 2.55 (t, J=7. 6 Hz, 2H); 3.11 (s, 3H); 3.73 (s, 3H); 4. 10 (t, J=7 Hz, 2H); 6.50 (d, J-3 Hz, 1H) ; 6.68 (d, J=8. 8 Hz, 2H); 7.01 (d, J=8. 8 Hz, 2H); 7. 09-7.10 (aromatics, 2 H); 7.23 (d, J=8. 8 Hz, 1H) ; 7.52 (d, J=2. 4 Hz, 1H).

IR (neat) cm-1 : 2931,1712, 1508,1362, 1225, 1176.

Mass m/z (CI): 472 [M+1].

Example 86 <BR> <BR> 1- [4- {4- (5-methanesulfonyloxyindol-1-yl) butyl} phenoxy] cyclopentane-1-carboxylic acid, methyl ester Obtained using starting material from step-1 of preparation 7 and preparation 40.

Yield: 600 mg, 83 %.

1H NMR (CDC13, 400 MHz) 8 : 1.57-1. 63 (m, 2H); 1.70-1. 88 (m, 6H); 2.10-2. 20 (m, 2H); 2.20-2. 30 (m, 2H); 2.54 (t, J=7. 7 Hz, 2H); 3.12 (s, 3H); 3.72 (s, 3H); 4.11 (t, J=7. 2 Hz, 2H); 6.48 (d, J=3. 2 Hz, 1H); 6.65 (d, J=8. 6 Hz, 2H); 6.97 (d, J=8. 6 Hz, 2H); 7.10-7. 14 (aromatics, 2 H); 7.28 (d, J=9. 0 Hz, 1H); 7.52 (d, J=2. 5 Hz, 1H).

IR (neat) cm-1 : 2939,1734, 1611,1508, 1177.

Mass m/z (ES): 486 [M+1], 503.4 [M+NH4+], 508,3 [M+Na+], 988.7 [M2+NH4+], 993.5 [M2+Na+].

Example 87 1- [4- {3- (7-Methanesulfonyloxy-3, 4-dihydro-2H-bezo [b] [1, 41 oxazin-4- yl) propyl} phenoxy] cyclopentane-1-carboxylic acid, methyl ester Using the typical procedure described in example 70 the title compound has been obtained.

Yield: 170 mg, 10 %.

IH NMR (CDCI3, 400 MHz) 8 : 1.75-1. 90 (m, 6H) ; 2.10-2. 20 (m, 2H); 2.20-2. 30 (m, 2H); 2.58 (t, J=7. 5 Hz, 2H); 3.07 (s, 3H); 3.22 (t, J=7. 4 Hz, 2H); 3.28 (t, J=4. 4 Hz, 2H); 3.73 (s, 3H); 4.20 (t, J=4. 4 Hz, 2H) ; 6.46 (d, J=6. 2 Hz, 1H) ; 6.67 (s, 1H) ; 6. 69 (d, J=6 Hz, 1H) ; 6. 75 (d, J=8. 6 Hz, 2H); 7.04 (d, J=8. 6 Hz, 2H); IR (neat) cm 1 : 3418,2947, 1735,1509, 1236,1179.

Mass m/z (CI): 489 [M], 490 [M+1].

Example 88 Ethyl 2-methyl-2- [4- {4- (7-methanesulfonyloxy-3, 4-dihydro-2H-bezo [b] [1, 4] oxazin- 3-on-4-yl) butyl}phenoxy]propanoate Using the typical procedure described in example 70 the title compound has been obtained.

Yield: 330 mg, 52 %.

'H NMR (CDCl3, 400 MHz) 8 : 1.25 (t, J=7. 2 Hz, 3H); 1.57 (s, 6H); 1.55-1. 70 (m, 4H); 2.60 (t, J=6. 6 Hz, 2H); 3.15 (s, 3H); 3.91 (t, J=7 Hz, 2H); 4.23 (q, J=7. 2 Hz, 2H); 4.61 (s, 2H); 6.77 (d, J=8. 8 Hz, 2H); 6.85-6. 98 (aromatics, 3H); 7.02 (d, J=8. 8 Hz, 2H).

IR (neat) cm-1 : 2936, 1732,1687, 1506.

Mass m/z (CI) : 506 [M+1].

Using the general ester hydrolysis procedure described in example 23 the following examples (examples 89-105) were obtained from their corresponding esters.

Example 89 2-Methyl-2-[3-{3-(7-Methanesulfonyloxy-3,4-dihydro-2H-bezo [b] [1, 4] oxazin-4-yl) propyl} phenoxyl propanoic acid.

Yield: 100 mg, 63 %.

'H NMR (CDC13, 400 MHz) 8 : 1.60 (s, 6H); 1.86-1. 95 (m, 2H); 2.63 (t, J=7.4Hz, 2H); 3.08 (s, 3H); 3.24 (t, J=7.4Hz, 2H); 3.29 (t, J=4.4Hz, 2H); 4.21 (t, J=4. 4Hz, 2H); 6.44 (d, J=8.8Hz, 2H); 6.47-6. 75 (aromatic, 2H); 6.77-6. 79 (aromatic, 2H); 6.91 (d, J=7.6Hz, 1H) ; 7.18-7. 23 (aromatic, 1H).

IR (Neat, cm'') : 3380,2935, 1730,1602, 1511.

Mass m/z (ES): 450 [M+1], 472.1 [M+Na], 921.7 [M2+Na].

Example 90 (R)- (+)-2-Methyl-2-14-{3-(5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] butanoic acid The hydrolysis was done by following the typical procedure described for example 23 except that the solvent mixture was MeOH-water and the reaction time was 3 days.

Thick liquid. Yield: 730 mg (88%) 'H NMR (CDC13, 400 MHz) 8 : 1.04 (t, J=7.6 Hz, 3H); 1.47 (s, 3H); 1.90-1. 99 (m, 1H) ; 1.99-2. 03 (m, 1H); 2.14 (quintet, J=7.6 Hz, 2H); 2.59 (t, J=7.8 Hz, 2H); 3.12 (s, 3H); 4.12 (t, J=6.9 Hz, 2H); 6.50 (d, J=3.2 Hz, 1H); 6.88 (d, J=8.8 Hz, 2H); 7.05 (d, J=8.4 Hz, 2H); 7.11 (dd, J= 2.4, 8.8 Hz, 1H); 7.15 (d, J= 3.2 Hz, 1H); 7.22 (d, J= 8.8 Hz, 1H) ; 7.52 (d, J=2.4 Hz, 1H).

IR (neat) cm-1: 2940,1716, 1509.

Mass m/z (ES): 446.3 [M + 1], 463.4 [M + NH4], 468.5 [M +Na], 913.7 [M2+Na] [a] D = +10° (c = 1%, MeOH, 25 °C) Example 91 (S)- (-)-2-methyl-2- [4- (3- (5-methanesulfonyloxyindol-1-yl) propyl) phenoxyl butanoic acid [a] D =-10° (c = 1%, MeOH, 25 °C) Example 92 2-methyl-2-[3{3-(4-(para-toluenesulfonyloxy)phenoxy)propylox y}phenoxy]propanoic acid Yield : 190 mg, 66 %.

'H NMR (CDC13, 400 MHz) 8 : 1.59 (s, 6H); 2.21 (quintet, J=6. 1 Hz, 2H); 2.44 (s, 3H); 4. 07-4.11 (m, 4H); 6.50-6. 53 (aromatics, 2H); 6.62 (d, J=8. 6 Hz, 1 H) ; 6.76 (d, J=9. 2 Hz, 2H); 6.87 (d, J=9. 2 Hz, 2H); 7.15 (t, J=8. 6 Hz, 1H) ; 7.29 (d, J=8. 1 Hz, 2H); 7.69 (d, J=8. 1 Hz, 2H).

IR (neat) cm-1: 3500,2926, 1713,1597, 1501,1150.

Mass m/z (ES): 501.3 [M+1], 518. 5 [M+NH4+], 523.3 [M2+NH4+].

Example 93 2-Methyl-2-[4-{3-(4-methanesulfonyloxyphenoxy)propyloxy}phen oxy]butanoic acid Yield: 70 mg, 13 %.

'H NMR (CDC13,400 MHz) 8 : 1.05 (t, J=7. 4 Hz, 3H); 1.41 (s, 3H); 1.82-2. 00 (m, 2H); 2.22-2. 28 (m, 2H); 3.11 (s, 3H); 4. 15 (t, J=6 Hz, 2H); 4.12 (t, J=6 Hz, 2H); 6.82 (d, J=9 Hz, 2H); 6.89-6. 94 (aromatics, 4H); 7.19 (d, J=9. 1 Hz, 2H).

IR (neat) cm-1 : 3360,2926, 1723,1593, 1503.

Mass m/z (ES): 456 [M+NH4+], 894.5 [M2+NH4+].

Example 94 2-Methyl-2-[4-{4-(4-methanesulfonyloxyphenyl)butyl}phenoxy] propanoic acid Yield: 110 mg, 59 %.

'H NMR (CDC13, 400 MHz) 8 : 1.56 (s, 6H); 1. 75-1.84 (m, 4H); 2.65 (t, J=7. 2 Hz, 2H); 3.1 (s, 3H); 3.95 (t, J=5. 9 Hz, 2H); 6.87 (d, J=9. 4 Hz, 4H); 7.10 (d, J=8. 6 Hz, 2H); 7.18 (d, J=9. 2 Hz, 2H).

IR (neat) cm-1 : 3441,2938, 1716,1503, 1151.

Mass m/z (ES): 440 [M+NH4+], 445 [M+Na+], 867.5 [M2+Na+].

Example 95 Zethyl-2- [3- {5- (4-methanesulfonyloxyphenoxy) pentyl} phenoxy] propanoic acid Yield : 180 mg, 64 %.

1H NMR (CDC13, 400 MHz# : 1.42-1. 55 (m, 2H); 1.59 (s, 6H); 1.60-1. 75 (m, 2H); 1.75-1. 85 (m, 2H); 2.60 (t, J=7. 6 Hz, 2H); 3.1 (s, 3H); 3.93 (t, J=6. 4 Hz, 2H); 6.70- 6. 78 (aromatics, 2H); 6.87-6. 91 (aromatics, 1H); 6.88 (d, J=9. 1 Hz, 2H); 7.17-7. 21 (aromatics, 1H); 7.19 (d, J=9. 1 Hz, 2H).

IR (neat) cm-1 : 3342,2936, 1716,1502, 1151.

Mass m/z (ES): 454.3 [M+NH4+], 459.3 [M+Na+], 890.5 [M2+NH4+], 895.5 [M2+Na+].

Example 96 2-Methyl-2- [4- {3- (4- (tert- butyloxycarbonylamino) phenoxy) propyl} phenoxy] propanoic acid Hydrolysis was done using K2CO3 as base instead of LiOH.

Yield: 35 mg, 27 %.

Mp: 132-134 °C.

'H NMR (CDC13, 400 MHz) 8 : 1.51 (s, 9H); 1.57 (s, 6H) ; 2.00-2. 08 (m, 2H); 2.75 (t, J=7. 4 Hz, 2H); 3.90 (t, J=6. 2 Hz, 2H); 6.4 (bs, NH, 1H) ; 6. 78 (d, J=8. 8 Hz, 2H); 6. 85 (d, J=8. 5 Hz, 2H); 7.10 (d, J=8. 5 Hz, 2H); 7.22 (d, J=8. 8 Hz, 2H).

IR (neat) cm-1 : 3307,2931, 1703,1506, 1159.

Mass m/z (ES): 430 [M+1], 447.4 [M+NH4+], 452.3 [M+Na+], 876.8 [M2+NH4+].

Example 97 2-Methyl-2-[4-{3-(4-(methanesulfonylamino) phenoxy) propyl} phenoxy propanoic acid Yield: 50 mg, 12 %.

Mp: 122-124 °C.

'H NMR (CDC13, 400 MHzO : 1.57 (s, 6H) ; 2.00-2. 08 (m, 2H) ; 2.76 (t, J=7. 6 Hz, 2H); 2.95 (s, 3H); 3.93 (t, J=6. 3 Hz, 2H); 6.2 (bs, NH, 1H) ; 6.86 (apparent triplet, J=8. 6 Hz, 4H); 7.11 (d, J=8. 8 Hz, 2H); 7.16 (d, J=8. 8 Hz, 2H).

IR (neat) cm-1: 3441, 2926, 1729,1510, 1147.

Mass m/z (ES): 425 [M+NH4+], 430 [M+Na+], 837 [M2+Na+].

Example 98 2-Methyl-2- [4- {4- (5-methanesulfonyloxyindol-lyl) butyl} phenoxy] propanoic acid Yield: 110 mg, 49 %.

'H NMR (CDC13, 400 MHz) 8 : 1.57 (s, 6H); 1. 57-1. 65 (m, 2H); 1.80-1. 90 (m, 2H) ; 2.57 (t, J=7. 6 Hz, 2H); 3.12 (s, 3H) ; 4.11 (t, J=7. 3 Hz, 2H); 6.49 (dd, J=3. 2,0. 6 Hz, 1H) ; 6.85 (d, J=8. 4 Hz, 2H); 7.00 (d, J=8. 4 Hz, 2H); 7.09-7. 13 (aromatics, 2 H); 7.27 (d, J=9. 5 Hz, 1H) ; 7.51 (d, J=2. 1 Hz, 1H).

IR (neat) cm-1 : 3375,2936, 1715,1177.

Mass m/z (ES): 446.1 [M+1], 463.3 [M+NH4+], 468.4 [M+Na+].

Example 99 2-Methyl-2-[3-{3-(5-(para-toluenesulfonyloxy)indol-1-yl)prop yl}phenoxy]propanoic acid Yield: 49 mg, 47 %.

'H NMR (CDC13, 400 MHz) 8 : 1.58 (s, 6H); 2.12-2. 17 (m, 2H); 2.44 (s, 3H) ; 2. 57 (t, J=7. 5 Hz, 2H); 4.08 (t, J=7. 0 Hz, 2H); 6.41 (d, J=2. 9 Hz, 1H); 6.73-6. 87 (aromatics, 4H); 7.07-7. 17 (aromatics, 2H); 7.18-7. 22 (aromatics, 2H); 7.29 (d, J=8. 3 Hz, 2H); 7.73 (d, J=8. 3 Hz, 2H).

IR (neat) cm-1: 3383,2932, 1733,1674, 1600,1178.

Mass m/z (ES): 508 [M+1], 525 [M+NH4+], 530 [M+Na+].

Example 100 2-[3-{3-(5-Methanesulfonyloxyindol-1-yl)propyl}phenoxy]propa noic acid Yield: 230 mg, 70 %.

'H NMR (CDC13, 400 MHz) 8 :, 1.63 (d, J=6. 9 Hz, 3H) ; 2.15 (quintet, J=7. 2 Hz, 2H); 2.57 (t, J=7. 5 Hz, 2H); 3.12 (s, 3H); 4.11 (t, J=7. 0 Hz, 2H) ; 4.75 (q, J=6. 9 Hz, 1H) ; 6. 50 (d, J=0. 6 Hz, 1H) ; 6.68 (s, 1H) ; 6.72 (d, J=2. 2 Hz, 1H) ; 6.74 (d, J=1. 9 Hz, 1H) ; 7.10-7. 22 (aromatics, 4 H); 7.51 (d, J=2. 4 Hz, 1H).

IR (neat) cm'l : 3378,2936, 1725,1177.

Mass m/z (ES): 418 [M+1], 435 [M+NH4+], 440.3 [M+Na+], 857.5 [M2+Na+].

Example 101 1- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] cyclohexane-1-carboxylic acid Yield : 36 mg, 21 %.

'H NMR (CDC13,400 MHz) 8 : 1.50-1. 65 (m, 6H); 1. 80-1. 95 (m, 2H); 2.11-2. 20 (m, 4H); 2.57 (t, J=7. 6 Hz, 2H); 3.12 (s, 3H); 4.10 (t, J=7 Hz, 2H) ; 6.50 (d, J=3. 3 Hz, 1H) ; 6.83 (d, J=8. 5 Hz, 2H); 7.02 (d, J=8. 5 Hz, 2H); 7.09-7. 17 (aromatics, 2 H); 7. 20 (d, J=8. 8 Hz, 1H) ; 7. 50 (d, J=2. 1 Hz, 1H).

IR (neat) cm'' : 3500,2938, 1733, 1509, 1386,1224, 1178.

Mass m/z (ES): 472.1 [M+1], 489.1 [M+NH4+], 494.5 [M+Na+], 960.5 [M2+NH4+].

Example 102 1-[4-{3-(5-Methanesulfonyloxyindol-1-yl)propyl}phenoxy]cyclo pentane-1-carboxylic acid Yield: 230 mg, 30 %.

'H NMR (CDC13, 400 MHz) 8 : 1.75-1. 86 (m, 4H); 2.10-2. 22 (m, 4H); 2.22-2. 35 (m, 2H); 2. 55 (t, J=7. 5 Hz, 2H); 3.11 (s, 3H) ; 4.10 (t, J=7. 2 Hz, 2H); 6.50 (d, J=3. 2 Hz, 1H) ; 6.74 (d, J=8. 6 Hz, 2H); 7.01 (d, J=8. 6 Hz, 2H); 7. 09-7.10 (aromatics, 2 H); 7.21 (d, J=8. 8 Hz, 1H) ; 7.51 (d, J=2. 4 Hz, 1H).

IR (neat) cm-1 : 3400,2937, 1710,1510, 1363,1177.

Mass m/z (ES): 458 [M+1], 475.4 [M+NH4+], 480.1 [M+Na+], 932.5 [M2+NH4+], 937.3 [M2+Na+].

Example 103 1-[4-{4-(5-methanesulfonyloxyindol-1-yl)butyl}phenoxy]cyclop entane-1-carboxylic acid Yield : 240 mg, 42 %.

'H NMR (CDC13,400 MHz) S : 1.55-1. 63 (m, 2H) ; 1.70-1. 88 (m, 6H); 2.15-2. 22 (m, 2H); 2.22-2. 35 (m, 2H); 2. 55 (t, J=7. 5 Hz, 2H) ; 3.12 (s, 3H); 4.10 (t, J=7. 1 Hz, 2H); 6.48 (d, J=3. 3 Hz, 1H); 6.71 (d, J=8. 4 Hz, 2H); 6.98 (d, J=8. 4 Hz, 2H); 7.09- 7.13 (aromatics, 2 H); 7.26 (d, J=9. 0 Hz, 1H); 7.50 (d, J=2. 5 Hz, 1H).

IR (neat) cm-1 : 3375,2926, 1730,1609, 1508,1177.

Mass m/z (ES): 472 [M+1], 489 [M+NH4+], 494.3 [M+Na+], 960.3 [M2+NH4+], 965.2 [M2+Na+].

Example 104 1-[4-{3-(7-Methanesulfonyloxy-3,4-dihydro-2H-bezo [b] [1, 4] oxazin-4- yl) propyl} phenoxy] cyclopentane-1-carboxylic acid Yield: 20 mg, 23 %.

'H NMR (CDCI3, 400 MHz) 5 : 1.75-1. 90 (m, 6H); 2.15-2. 25 (m, 2H) ; 2. 25-2.35 (m, 2H); 2.59 (t,. J=7. 4 Hz, 2H); 3.07 (s, 3H); 3.21 (t, J=7. 5 Hz, 2H); 3.28 (t, J=4. 4 Hz, 2H); 4.20 (t, J=4. 4 Hz, 2H); 6.38 (d, J=6. 2 Hz, 1H) ; 6.68 (s, 1H) ; 6.69 (d, J=6 Hz, 1H) ; 6.76 (d, J=8. 6 Hz, 2H); 7.06 (d, J=8. 6 Hz, 2H); IR (neat) cm-1: Mass m/z (CI) : 476 [M+1].

Example 105 2-Methyl-2-[4-{4-(7-methanesulfonyloxy-3,4-dihydro-2H-bezo [b] [1, 4] oxazin-3-on- 4-yl) butyl} phenoxy] propanoic acid Yield: 120 mg, 40 %.

'H NMR (CDC13, 400 MHz) 5 : 1.58 (s, 6H); 1.62-1. 68 (m, 4H); 2.62 (t, J=6. 8 Hz, 2H); 3.17 (s, 3H); 3.91 (t, J=7 Hz, 2H); 4.62 (s, 2H); 6.84-6. 90 (aromatics, 5H) ; 7.07 (d, J=9. 2 Hz, 2H).

IR (neat) cm-1: 3383,2934, 1730,1682, 1505,1123.

Mass m/z (ES): 478 [M+1], 495.3 [M+NH4+], 472.2 [M2+NH4+].

The following arginine salts (examples 106-117) were obtained from their corresponding acids following the procedure described in example 45.

Example 106 <BR> <BR> <BR> 2-Methyl-2- [3- {3- (7-Methanesulfonyloxy-3, 4-dihydro-2H-bezo [b] 11, 4] oxazin-4-yl) propyl} phenoxy] propanoic acid, Arginine salt Mp: 130-132 °C.

Example 107 (R)- (+)-2-methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] butanoic acid, Arginine salt Mp: 100-102 °C (dec).

Example 108 (5)- (-)-2-methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] butanoic acid, Arginine salt This Arginine salt was made using the typical procedure described for example 45.

Mp: 110 °C (dec), Example 109 2-Methyl-2- [3- {3- (4- (para- toluenesulfonyloxy) phenoxy) propyloxy} phenoxylpropanoic acid, arginine salt Mp: 118-120 °C.

Example 110 2-Methyl-2- [4- {3- (4-methanesulfonyloxyphenoxy) propyloxy} phenoxy] butanoic acid, arginine salt Mp: 90 °C (dec).

Example 111 <BR> <BR> <BR> 2-Methyl-2- [4- {4- (4-methanesulfonyloxyphenoxy) butyl} phenoxy] propanoic acid, arginine salt Mp: 156-158 °C.

Example 112 2-Methyl-2- [3- {5- (4-methanesulfonyloxyphenoxy) pentyl} phenoxy] propanoic acid, arginine salt Mp : 106-108 °C.

Example 113 2-Methyl-2- [4- {4- (5-methanesulfonyloxyindol-lyl) butyl} phenoxy] propanoic acid, arginine salt Mp : 128-130 °C.

Example 114 2-Methyl-2-[3-{3-(5-(para-toluenesulfonyloxy)indol-1-yl)prop yl}phenoxy] propanoic acid, arginine salt Mp: 118 °C Example 115 2-[3-{3-(5-Methanesulfonyloxyindol-1-yl)propyl}phenoxy]propa noic acid, arginine salt Arg salt : Mp: 110 112 °C.

Example 116 <BR> <BR> <BR> 1- [4- {4- (5-Methanesulfonyloxyindol-1-yl) butyl} phenoxy] cyclopentane-1-carboxylic acid, arginine salt Mp : 98-100 °C.

Example 117 <BR> <BR> <BR> 2-Methyl-2- [4- {4- (7-methanesulfonyloxy-3, 4-dihydro-2H-bezo [b] [1, 4] oxazin-3-on-.

4-yl) butyl} phenoxylpropanoic acid, Arginine salt Mp: 126-128 °C.

Example 118 Methyl-2-methyl-2- [4- {3- (5-methanesulfonyloxyindol-1-yl) propyl} phenoxy] butanoic acid Magnesium salt A solution of racemic 2-methyl-2- [4- {3- (5-methanesulfonyloxyindol-yl) propyl} phenoxy] butanoic acid (1 mmol), obtained following a racemic synthesis of example 90, in 5 mL of dry MeOH was treated with 0.5 mmol of Mg (OMe) 2 and the reaction mixture was stirred at 70 °C for 17 h. Then MeOH was completely removed and it was azeotropically dried with benzene. Finally it was dried over high vacuum pump to get the salt as almost white solid (quantitative yield). Mp: 136 °C (dec).

Example 119 <BR> <BR> <BR> <BR> 1-14-{3-(5-methanesulfonyloxyindol-l-yl) propyl} phenoxy] cyclohexane-l-carboxylic acid, magnesium salt Mp: 138 °C (dec).

Example 120 1- [4- {3- (5-Methanesulfonyloxyindol-1-yl) propyl} phenoxy] cyclopentane-l-carboxylic acid, magnesium salt Mp: 111 °C (dec).

Example 121 <BR> <BR> 1- [4- {3- (7-Methanesulfonyloxy-3, 4-dihydro-2H-bezo [b] [1, 4] oxazin-4- yl) propyl} phenoxy] cyclopentane-1-carboxylic acid, magnesium salt Mg salt: Mp: 158-160 °C (dec).

Demonstration of Efficacy of Compounds The compounds of the present invention lower random blood sugar level, triglyceride, total cholesterol, LDL, VLDL and increase HDL and insulin sensitivity. This may be demonstrated by in vitro as well as in vivo animal experiments.

In vitro: a) Determination of hPPARa activity Ligand binding domain of hPPARa was fused to A binding domain of Yeast transcription factor GAL4 in eucaryotic expression vector. Using superfect (Qiagen, Germany) as transfecting reagent HEK-293 cells are transfected with this plasmid and a reporter plasmid harboring the luciferase gene driven by a GAL4 specific promoter. Compound can be added at different concentrations after 42 hrs of transfection and incubated overnight. Luciferase activity as a function of compound binding/activation capacity of PPARa will be measured using Packard Luclite kit (Packard, USA) in Top Count (Ivan Sadowski, Brendan Bell, Peter Broag and Melvyn Hollis. Gene. 1992. 118 : 137-141; Superfect Transfection Reagent Handbook. February 1997. Qiagen, Germany). b) Determination of hPPARv activity Ligand binding domain of hPPARyl is fused to DNA binding domain of Yeast transcription factor GAL4 in eucaryotic expression vector. Using lipofectamine (Gibco BRL, USA) as transfecting reagent HEK-293 cells are transfected with this plasmid and a reporter plasmid harboring the luciferase gene driven by a GAL4 specific promoter.

Compound can be added at 1 « concentration after 48 hrs of transfection and incubated overnight. Luciferase activity as a function of drug binding/activation capacity of PPARyl will be measured using Packard Luclite kit (Packard, USA) in Packard Top Count (Ivan Sadowski, Brendan Bell, Peter Broag and Melvyn Hollis. Gene. 1992. 118 : 137-141; Guide to Eukaryotic Transfections with Cationic Lipid Reagents. Life Technologies, GIBCO BRL, USA). Compound PPAR fold activation PPAR a at 50yM PPAR Sy at 1 concentration ItM concentration Example 1 2. 7 9. 2 Example 2 3. 5 15. 5 Example 24 7. 4 4. 5 Example 45 5.2 1.4 Example 46 3. 2 2. 1 Example 47 4. 8 6. 7 Example 48 4. 6 6. 1 Example 49 3. 6 1. 5 Example 50 3. 5 1. 4 Example 52 4. 0 6 Example 53 3. 7 5. 8 Example 55 3. 8 11. 9 In vivo a) Efficacy in genetic models Mutation in colonies of laboratory animals and different sensitivities to dietary regimens have made the development of animal models with non-insulin dependent diabetes and hyperlipidemia associated with obesity and insulin resistance possible. Genetic models such as db/db and ob/ob (Diabetes, (1982) 31 (1) : 1-6) mice and zucker fa/fa rats have been developed by the various laboratories for understanding the pathophysiology of disease and testing the efficacy of new antidiabetic compounds (Diabetes, (1983) 32: 830- 838 ; Annu. Rep. Sankyo Res. Lab. (1994). 46: 1-57). The homozygous animals, C57 BL/KsJ-db/db mice developed by Jackson Laboratory, US, are obese, hyperglycemic, hyperinsulinemic and insulin resistant (J. Clin. Invest. , (1990) 85: 962-967), whereas heterozygous are lean and normoglycemic. In db/db model, mouse progressively develops insulinopenia with age, a feature commonly observed in late stages of human type II diabetes when blood sugar levels are insufficiently controlled. The state of pancreas and its course vary according to the models. Since this model resembles that of type II diabetes mellitus, the compounds of the present invention will be tested for blood sugar and triglycerides lowering activities.

Male C57BL/KsJ-db/db mice of 8 to 14 weeks age, having body weight range of 35 to 60 grams, bred at Dr. Reddy's Research Foundation (DRF) animal house, were used in the experiment. The mice are provided with standard feed (National Institute of Nutrition (NIN), Hyderabad, India) and acidified water, ad libitum. The animals having more than 350 mg/dl blood sugar will be used for testing. The number of animals in each group will be 4.

Test compounds are suspended on 0.25 % carboxymethyl cellulose and administered to test group at a dose of 0.1 mg to 30 mg/kg through oral gavage daily for 6 days. The control group receives vehicle (dose 10 ml/kg). On 6th day the blood samples will be collected one hour after administration of test compounds/vehicle for assessing the biological activity.

The random blood sugar and triglyceride levels can be measured by collecting blood (100 1ll) through orbital sinus, using heparinised capillary in tubes containing EDTA which was centrifuged to obtain plasma. The plasma glucose and triglyceride levels can be measured spectrometrically, by glucose oxidase and glycerol-3-PO4 oxidase/peroxidase enzyme (Dr. Reddy's Lab. Diagnostic Division Kits, Hyderabad, India) methods respectively. db/db Compound % of reduction in % of reduction in Dose mg/lig/d Plasma glucose Triglyceride Example 45 32 28 b) Plasma triglyceride and total cholesterol lowering activitv in Swiss albino mice and Guinea pips Male Swiss albino mice (SAM) and male Guinea pigs are obtained from NIN and housed in DRF animal house. All these animals are maintained under 12 hour light and dark cycle at 25 1 °C. Animals are given standard laboratory chow (NIN, Hyderabad, India) and water, ad libitum. SAM of 20-25 g body weight range and Guinea pigs of 500-700 g body weight range are used (Oliver, P., Plancke, M. O., Marzin, D. , Clavey, V. , Sauzieres, J and Fruchart, J. C. Effects of fenofibrate, gemfibrozil and nicotinic acid on plasma lipoprotein levels in normal and hyperlipidemic mice. Atherosclerosis. 1988. 70 : 107-114).

The test compounds can be administered orally to Swiss albino mice at 0. 3 to 30 mg/kg/day dose for 6 days. Control mice are treated with vehicle (0.25% Carboxymethylcellulose; dose 10 ml/kg). The test compounds are administered orally to Guinea pigs at 0.3 to 30 mg/kg/day dose for 6 days. Control animals are treated with vehicle (0.25% Carboxymethylcellulose; dose 5 ml/kg).

The blood samples can be collected in fed state 1 hour after drug administration on 0 and 6 day of treatment. The blood can be collected from the retro-orbital sinus through heparinised capillary in EDTA containing tubes. After centrifugation, plasma sample was separated for triglyceride and total cholesterol (Wieland, O. Methods of Enzymatic analysis. Bergermeyer, H. O., Ed. , 1963.211-214 ; Tinder, P. Ann. Clin. Biochem. 1969.

6: 24-27). Measurement of plasma triglyceride, total cholesterol and HDL are done using commercial kits (Dr. Reddy's Diagnostic Division, Hyderabad, India). Compound Swiss albino mice Dose (mg % of /kg/d) Reduction in Triglyceride Example 2 3 50 Example 24 3 46 Example 26 3 10 Example 37 3 30 Example 45 3 60 Example 46 10 12 Example 47 3 60 Example 48 3 27 Example 49 3 54 Example 50331 Example 53 3 79 Example 54 3 43 Example 55 3 60 Example 61 3 51 Example 66 3 71