NOVEL CONDENSED THIAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

WIPO Patent Application WO/1994/006791

A1

A condensed thiazole derivative useful as a 5-HT3 receptor agonist, represented by general formula (I), a pharmaceutically acceptable salt thereof, a process for producing the same, and a pharmaceutical composition containing the same, wherein R represents hydrogen, halogen, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, nitro, amino, cyano or protected hydroxy; A represents a benzene or naphthalene ring; one of L1 and L2 represents a mere bond while the other then represents: (a) linear or branched lower alkylene which may be interrupted by oxygen or sulfur, (b) oxygen or sulfur, or (c) lower alkenylene; L represents a mere bond, or linear or branched lower alkylene; Im represents alpha or beta; R1, R2 and R3 may be the same or different from one another and each represents hydrogen or lower alkyl; and R4, R5 and R6 may be the same or different from one another and each represents hydrogen or lower alkyl.

IWAOKA KIYOSHI (JP)
KOSHIO HIROYUKI (JP)
ITO HIROYUKI (JP)
MIYATA KEIJI (JP)
OHTA MITSUAKI (JP)

PCT/JP1993/001298

March 31, 1994

September 10, 1993

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YAMANOUCHI PHARMA CO LTD (JP)
IWAOKA KIYOSHI (JP)
KOSHIO HIROYUKI (JP)
ITO HIROYUKI (JP)
MIYATA KEIJI (JP)
OHTA MITSUAKI (JP)

A61K31/425; A61K31/428; A61P1/06; A62C2/06; E06B5/12; B21D31/04; B31D1/00; B31D3/04; B31D5/00; B32B3/24; B65D81/02; C07D417/04; C07D417/06; C07D513/04; C07D521/00; E04B1/92; E04H9/00; E04H9/14; E06B9/00; F42D5/045; (IPC1-7): C07D417/04; C07D417/06; C07D513/04; A61K31/425

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